Effect of Milk Replacer Feeding Level and Concentration on Feed Utilization, Growth Performance, and Blood Parameters of Hanwoo Calves.

This study aims to determine appropriate milk replacer feeding amounts and concentrations for artificial suckling of Hanwoo calves by analyzing growth and blood parameters in response to varying feeding levels and concentrations. A total of 90 Hanwoo calves (45 females; 45 males) (Mean weight 30.84 (3.

Effect of the Temperature-Humidity Index on the Productivity of Dairy Cows and the Correlation between the Temperature-Humidity Index and Rumen Temperature Using a Rumen Sensor.

This study was conducted to evaluate the effects of high-temperature stress on dairy cow productivity and the correlation between rumen sensors. The data were collected on the temperature, humidity, milk productivity, milk components, blood components, and rumen sensor data from 125 dairy cows during the experimental period (1 May 2020 to 30 October 2020). High-temperature stress of dairy cows was evaluated based on the temperature-humidity index (THI).

Identification of Individual Cattle by Muzzle Pattern Images through Deep Learning.

The objective of this study was to identify cattle via a deep-learning model using muzzle images. A total of 9230 images from 336 were used. Images of the same individuals were taken at four different times to avoid overfitted models.

Fermentation characteristics of bedded pack barn dairy cattle manure on methane yield, carbon, and nitrogen content in solid-state anaerobic digestion.

This study aimed to estimate the fermentation characteristics of bedded pack barn dairy cattle manure (BDCM) in terms of methane yield, fibrous material, and nitrogen content in batch solid-state anaerobic digestion (SSAD). SSAD was performed in triplicate using a 1,400 ml polypropylene bottle at a constant temperature of 39 °C until less than 1% methane was produced. The cumulative methane content of BDCM was 142.

Effects of starch sugar by-product on rumen digestibility, disappearance rate, and milking productivity of the lactating dairy cow.

Objective: The purpose of the present study was to determine the effects of starch sugar by-product (SSB) feeding on the rumen digestibility, disappearance rate, and lactating dairy cow.

Methods: To determine the rumen digestibility, 50 mL of the buffer-rumen fluid mixture was dispensed into a 125 mL serum bottle containing 0.5 g of dry matter (DM) of substrates.

Effects of feeding starch sugar by-products on in situ rumen disappearance rate, growth performance, and carcass characteristics of late finishing Hanwoo steers.

Objective: The aim of this study was to determine the effects of feeding starch sugar by-products (SSBs) on in situ disappearance rate, performance, and carcass characteristics of Hanwoo steers in the late finishing stage.

Methods: To determine the in situ disappearance rate, nylon bags filled with 5 g of SSB were inserted into the ventral sac of two cannulated Holsteins cows and incubated for 0, 2, 4, 8, 16, 24, and 48 h. A total of 30 Hanwoo steers were fed the experimental diets, which were basal diet (control) and 7% SSB on an as-fed basis (4.

Determination of in situ degradation parameters and feeding level of pineapple (Ananas comosus L.) cannery by-product to Hanwoo steers.

Objective: The objectives of this study were to determine the in situ degradation parameters and appropriate feeding level of pineapple cannery by-products (PCB) based on the growth performance and blood parameters of growing Hanwoo (Bos taurus coreanae) steers fed various levels of PCB.

Methods: Two ruminally cannulated Holstein cows were used for in situ disappearance rate measurements. Nylon bags (5×10 cm, 45 μm pore size) filled with 5 g of PCB in triplicate were inserted into the ventral sac of the two cannulated Holsteins cows and incubated for 0, 2, 4, 8, 16, 24, and 48 h.

Effects of a pineapple (Ananas comosus L.) cannery by-product on growth performance and carcass characteristics in finishing Hanwoo steers.

Objective: The aim of this study was to determine the effect of pineapple cannery by-product (PCB) level on the growth performance and carcass characteristics of finishing Hanwoo steers.

Methods: The feeding stage was divided into early and late finishing stages. A total of 60 castrated Hanwoo steers (13.

Effect of fermented spent instant coffee grounds on milk productivity and blood profiles of lactating dairy cows.

Objective: This study was conducted to evaluate the fermentation characteristics under low mesophilic temperature of spent instant coffee ground (SICG) and to estimate the effect of fermented SICG (FSICG) as alternative feed ingredient on milk productivity of dairy cows.

Methods: In the fermentation trial, fermentation of SICG was performed to investigate changes in characteristics using the microbial mixture (Lactobacillus plantarum, Saccharomyces cerevisiae, and Bacillus subtilis = 1:1:1) for 21 days at 20°C under anaerobic conditions. Molasses was added at 5% of dry mass.

Ruminal methane emissions, metabolic, and microbial profile of Holstein steers fed forage and concentrate, separately or as a total mixed ration.

Few studies have examined the effects of feeding total mixed ration (TMR) versus roughage and concentrate separately (SF) on ruminant methane production. Therefore, this study compared differences in methane production, ruminal characteristics, total tract digestibility of nutrients, and rumen microbiome between the two feeding methods in Holstein steers. A total six Holstein steers of initial bodyweights 540 ± 34 kg were divided into two groups and assigned to a same experimental diet with two different feeding systems (TMR or SF) in a crossover design with 21 d periods.

Effects of dietary supplementation with fermented and non-fermented brown algae by-products on laying performance, egg quality, and blood profile in laying hens.

Objective: This study was conducted to investigate the effects of dietary supplementation with fermented and non-fermented brown algae by-products on the laying performance, egg quality, relative organ weight, and blood profile of laying hens.

Methods: Hy-Line Brown chickens (n = 180; 70-week-old) were randomly divided into 5 groups with 4 replicates per group (3 hens per cage, 4 cages per replicate), and fed with 5 experimental diets, namely the basal control diet (CON) or the control diet supplemented with 0.5% brown seaweed (BS), 0.

Effects of feeding level on nutrient digestibility and enteric methane production in growing goats (Capra hircus hircus) and Sika deer (Cervus nippon hortulorum).

Objective: Two experiments were conducted to determine the effects of feeding level on nutrient digestibility and enteric methane (CH4) emissions in growing goats and Sika deer.

Methods: Three growing male goats (initial body weight [BW] of 22.4±0.

Effects of dietary fermented spent coffee ground on nutrient digestibility and nitrogen utilization in sheep.

Objective: The objective of the study was to determine the effect of fermented spent coffee ground (FSCG) on nutrient digestibility and nitrogen utilization in sheep.

Methods: Fermentation of spent coffee ground (SCG) was conducted using . Fermentation was performed at moisture content of 70% and temperature of 39°C with anaerobic air tension for 48 h.

Effects of dietary forage-to-concentrate ratio on nutrient digestibility and enteric methane production in growing goats () and Sika deer ().

Objective: Two experiments were conducted to determine the effects of forage-to-concentrate (F:C) ratio on the nutrient digestibility and enteric methane (CH) emission in growing goats and Sika deer.

Methods: Three male growing goats (body weight [BW] = 19.0±0.

Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors.

A novel series of 2-amino-1,3,5-triazines bearing a tricyclic moiety as heat shock protein 90 (Hsp90) inhibitors is described. Molecular design was performed using X-ray cocrystal structures of the lead compound CH5015765 and natural Hsp90 inhibitor geldanamycin with Hsp90. We optimized affinity to Hsp90, in vitro cell growth inhibitory activity, water solubility, and liver microsomal stability of inhibitors and identified CH5138303.

Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design.

Heat shock protein 90 (Hsp90) is a molecular chaperone which regulates maturation and stabilization of its substrate proteins, known as client proteins. Many client proteins of Hsp90 are involved in tumor progression and survival and therefore Hsp90 can be a good target for developing anticancer drugs. With the aim of efficiently identifying a new class of orally available inhibitors of the ATP binding site of this protein, we conducted fragment screening and virtual screening in parallel against Hsp90.