Simultaneous quantification method for eleutheroside B, eleutheroside E, chiisanoside, and sesamin using reverse-phase high-performance liquid chromatography coupled with ultraviolet detection and integrated pulsed amperometric detection.

We developed a method combining ultraviolet (UV) detection and integrated pulsed amperometric detection (IPAD) to simultaneously analyze eleutheroside B, eleutheroside E, chiisanoside, and sesamin. The gradient elution system allowed complete separation of all target components within 35 min, and showed limits of detection of 0.006-0.

Association of restrictive ventilatory dysfunction with the development of prediabetes and type 2 diabetes in Koreans.

Aims: This study was performed to investigate whether ventilatory dysfunction is a predictor for the development of prediabetes and type 2 diabetes in Koreans.

Methods: We analyzed the clinical and laboratory data of 16,195 Korean adults (age 20-79 years) who underwent routine medical checkups with a mean 4.7-years (range 3.

Severity of systemic calcified atherosclerosis is associated with airflow limitation and emphysema.

Objective: We investigated the association between systemic calcified atherosclerosis and airflow limitation.

Methods: A prospective cohort of 134 patients with chronic obstructive pulmonary disease (male:female = 124:10; mean age, 65.4 years) and 101 smokers without airflow limitation (male:female = 87:14; mean age, 51.