Long-term follow-up of ureteral stump tumors after nephrectomy for benign renal disease.

Objective: The occurrence of primary carcinoma of the ureteral stump after nephrectomy is rare. In this study, we evaluated the clinical characteristics of ureteral stump tumors after nephrectomy for benign renal disease.

Methods: During a 16-year period, 318 consecutive patients underwent simple nephrectomy for benign renal disease (216 cases) or for donation (102 cases).

Design and experiments of a near-field optical disk head for very high efficiency.

A high-density optical disk system with super parallel optical heads using a vertical cavity surface emitting laser (VCSEL) array is described for higher data transfer rate and technological capability. Optical heads of the VCSEL array and microlens array play key roles for obtaining higher evanescent light from small apertures with the optical disk, which is coated with lubricant and protective films on the flat surface in order to keep the gap between the super parallel optical head and the disk surface within 20 nm. Higher throughput efficiency has been obtained in the near-field semiconductor optical probe array head.

[Association of diet with menopausal symptoms in Korean middle-aged women].

Purpose: This study was designed to explore the association of diet with menopausal symptoms in Korean women.

Method: For this cross-sectional survey, 276 women aged between 45-55 years visiting two branches of K-university hospital located in Seoul and Ansan of Kyunggi province were recruited from April to July, 2002. A menopause-specific quality-of-life questionnaire and a food frequency questionnaire were used to measure menopause-related symptoms and the intake of 28 types of foods.

Redefinition of multiple sclerosis plaque size using diffusion tensor MRI.

Objective: We used diffusion tensor MRI to redefine the size of multiple sclerosis (MS) plaques on fractional anisotropy (FA) maps.

Materials And Methods: Thirty-six white matter (WM) plaques were identified in 20 patients with MS. Plaque FA was measured by placing regions of interest (ROIs) on plaques on diffusion tensor images.

Probing the transition-state structure of dual-specificity protein phosphatases using a physiological substrate mimic.

Dual-specificity phosphatases (DSPs) belong to the large family of protein tyrosine phosphatases that contain the active-site motif (H/V)CxxGxxR(S/T), but unlike the tyrosine-specific enzymes, DSPs are able to catalyze the efficient hydrolysis of both phosphotyrosine and phosphoserine/threonine found on signaling proteins, as well as a variety of small-molecule aryl and alkyl phosphates. It is unclear how DSPs accomplish similar reaction rates for phosphoesters, whose reactivity (i.e.

Transgenic mice overexpressing cyclophilin A are resistant to cyclosporin A-induced nephrotoxicity via peptidyl-prolyl cis-trans isomerase activity.

Cyclosporin A (CsA) suppresses immune reaction by inhibiting calcineurin activity after forming complex with cyclophilins and is currently widely used as an immunosuppressive drug. Cyclophilin A (CypA) is the most abundantly and ubiquitously expressed family member of cyclophilins. We previously showed that CsA toxicity is mediated by ROS generation as well as by inhibition of peptidyl-prolyl cis-trans isomerase (PPIase) activity of CypA in CsA-treated myoblasts [FASEB J.

Intramolecular dephosphorylation of ERK by MKP3.

The dual specificity mitogen-activated protein kinase phosphatase MKP3 downregulates mitogenic signaling through dephosphorylation of extracellular signal-regulated kinase (ERK). Like other MKPs, MKP3 consists of a noncatalytic N-terminal domain and a catalytic C-terminal domain. ERK binding to the N-terminal noncatalytic domain of MKP3 has been shown to increase (up to 100-fold) the catalytic activity of MKP3 toward small artificial substrates.

Clinical accuracy of a new apex locator with an automatic compensation circuit.

A new circuit was designed to automatically compensate for measurement errors of an electronic apex locator in various electrolytes. Thirty-one root canals were clinically tested for accuracy. A file was inserted into the canal until the apex signal was obtained, at which point the file was immobilized with glass-ionomer cement.