Publications by authors named "Youngje Oh"
Am J Chin Med
January 2017
Article Synopsis
- Alzheimer's disease (AD) is a neurodegenerative condition marked by amyloid-beta accumulation, oxidative damage, inflammation, and altered signaling pathways, leading to the need for alternative treatments.
- This study explores the neuroprotective effects of Coriandrum sativum (C. sativum) extract, showing it can increase cell survival and reduce cell death caused by Aβ in both mammalian cells and fruit flies.
- C. sativum extract appears to diminish oxidative stress and inflammation by inhibiting the ERK signaling pathway, suggesting it may offer potential as a treatment for AD through its antioxidant and anti-inflammatory properties.
Biol Pharm Bull
September 2016
Article Synopsis
- Alzheimer's disease (AD) is a leading neurodegenerative disorder linked to amyloid β-peptide (Aβ) plaques, and current medication's effectiveness is debated.
- Researchers created a fast screening method using Drosophila models to test 23 traditional Chinese medicinal plants for neuroprotective properties, finding five effective ones, particularly Coriandrum sativum and Nardostachys jatamansi.
- P. multiflorum and Sorbus commixta extracts significantly improved survival and reduced cell death in Aβ-expressing flies and human cells, indicating their potential as therapies for neurodegenerative diseases like AD.
