α-Synuclein Strain Dynamics Correlate with Cognitive Shifts in Parkinson's Disease.

α-Synuclein (α-syn) strains can serve as discriminators between Parkinson's disease (PD) from other α-synucleinopathies. The relationship between α-syn strain dynamics and clinical performance as patients transition from normal cognition (NC) to cognitive impairment (CI) is not known. Here, we show that the biophysical properties and neurotoxicity of α-syn strains change as PD cognitive status transitions from NC to mild cognitive impairment (PD-MCI) and dementia (PD-D).

Shifts in Residential Mobility Predict Shifts in Culture.

Does residential mobility change cultures, or is it merely a downstream indicator for other forces? Using large-scale surveys of citizens of 18 industrialized nations, we find that increased rates of residential mobility predict living in a more dynamic society at least 10 years in the future: one in which residents are more satisfied with their lives, have greater optimism, endorse more individualistic concepts, are more open to new ideas, have a greater sense of freedom of action, feel able to make friends more easily, express a more cosmopolitan identity, believe that their society rewards merit, and hold their community to a higher standard for treatment of minorities. These findings are echoed in the experience of Americans who have themselves recently moved, where we find that having successfully moved predicts a future sense of personal thriving, optimism, and a belief that merit is rewarded.

Differing worldviews: The politics of happiness, meaning, and psychological richness.

Objective/background: Conservative ideology, broadly speaking, has been widely linked to greater happiness and meaning in life. Is that true of all forms of a good life? We examined whether a psychologically rich life is associated with political orientation, system justification, and Protestant work ethic, independent of two other traditional forms of a good life: a happy life and a meaningful life.

Method: Participants completed a questionnaire that assessed conservative worldviews and three aspects of well-being (N = 583 in Study 1; N = 348 in Study 2; N = 436 in Study 3; N = 1,217 in Study 4; N = 2,176 in Study 5; N = 516 in Study 6).

Association between serum high-density lipoprotein cholesterol and lung function in adults: three cross-sectional studies from US and Korea National Health and Nutrition Examination Survey.

Introduction: Cholesterol is an irreplaceable nutrient in pulmonary metabolism; however, studies on high-density lipoprotein cholesterol (HDL-C) levels have shown conflicting results regarding lung function. Therefore, we investigated the association between lung function and HDL-C levels in three cross-sectional studies conducted in the USA and South Korea.

Methods: US National Health and Nutrition Examination Survey (NHANES) III, US NHANES 2007-2012, and Korea National Health and Nutrition Examination Survey (KNHANES) IV-VII performed spirometry and met the American Thoracic Society recommendations.

Money and happiness: the income-happiness correlation is higher when income inequality is higher.

Has the income-happiness correlation changed over time? If so, what predicts such changes? We tested these questions in diverse economic, political, and cultural contexts. Drawing on nationally representative data, we found that the income-happiness correlation has increased in the USA since 1972, as GDP per capita and income inequality increased (Study 1). Study 2 examined an income-life satisfaction correlation in nationally representative surveys between 1978 and 2011 in Japan.

Experimental and cross-cultural evidence that parenthood and parental care motives increase social conservatism.

Differences in attitudes on social issues such as abortion, immigration and sex are hugely divisive, and understanding their origins is among the most important tasks facing human behavioural sciences. Despite the clear psychological importance of parenthood and the motivation to provide care for children, researchers have only recently begun investigating their influence on social and political attitudes. Because socially conservative values ostensibly prioritize safety, stability and family values, we hypothesized that being more invested in parental care might make socially conservative policies more appealing.

American and Korean Perceptions of Sex Differences in Deception.

Beliefs about which sex lies more or is better at lying can have subtle but widespread effects on human interactions, yet little is known about such beliefs. In Study 1, an American sample of participants ( = 407, ages 18-64) completed a 12-item survey on perceptions of sex differences in deception. In Study 2, a Korean sample ( = 197, ages 19-58) completed the same survey.

Social networks and inference about unknown events: A case of the match between Google's AlphaGo and Sedol Lee.

This study examines whether the way that a person makes inferences about unknown events is associated with his or her social relations, more precisely, those characterized by ego network density that reflects the structure of a person's immediate social relation. From the analysis of individual predictions over the Go match between AlphaGo and Sedol Lee in March 2016 in Seoul, Korea, this study shows that the low-density group scored higher than the high-density group in the accuracy of the prediction over a future state of a social event, i.e.