MicroRNA-150 modulates intracellular Ca levels in naïve CD8 T cells by targeting TMEM20.

Regulation of intracellular Ca signaling is a major determinant of CD8 T cell responsiveness, but the mechanisms underlying this regulation of Ca levels, especially in naïve CD8 T cells, are not fully defined. Here, we showed that microRNA-150 (miR-150) controls intracellular Ca levels in naïve CD8 T cells required for activation by suppressing TMEM20, a negative regulator of Ca extrusion. miR-150 deficiency increased TMEM20 expression, which resulted in increased intracellular Ca levels in naïve CD8 T cells.