Recent Technological and Intellectual Property Trends in Antibody-Drug Conjugate Research.

Antibody-drug conjugate (ADC) therapy, an advanced therapeutic technology comprising antibodies, chemical linkers, and cytotoxic payloads, addresses the limitations of traditional chemotherapy. This study explores key elements of ADC therapy, focusing on antibody development, linker design, and cytotoxic payload delivery. The global rise in cancer incidence has driven increased investment in anticancer agents, resulting in significant growth in the ADC therapy market.

Highly Dispersed Pt-Incorporated Mesoporous FeO for Low-Level Sensing of Formaldehyde Gas.

Highly dispersed Pt-incorporated mesoporous FeO (Pt/m-FeO) of 4 μm size is prepared through a simple hydrothermal reaction and thermal decomposition procedures. Furthermore, the formaldehyde gas-sensing properties of Pt/m-FeO are investigated. Compared with our previous mesoporous FeO-based gas sensors, a gas sensor based on 0.

Dexamethasone-Loaded Radially Mesoporous Silica Nanoparticles for Sustained Anti-Inflammatory Effects in Rheumatoid Arthritis.

Radially mesoporous silica nanoparticles (RMSNs) with protonated amine functionality are proposed to be a dexamethasone (Dex) carrier that could achieve a sustained anti-inflammatory effect in rheumatoid arthritis (RA). High-capacity loading and a sustained release of target drugs were achieved by radially oriented mesopores and surface functionality. The maximum loading efficiency was confirmed to be about 76 wt%, which is about two times greater than that of representative mesopores silica, SBA-15.

pH- and temperature-responsive radially porous silica nanoparticles with high-capacity drug loading for controlled drug delivery.

The design of smart and functional nanocarriers for drug delivery systems that use a variety of organic and inorganic materials has led to the development of nanomedicines with improved therapeutic efficiency and reduced side effects. In this study, a pH- and temperature-responsive, controlled-release system with a high capacity for drug loading was developed based on radially porous silica nanoparticles composed of functionalized ligands and polymer encapsulation. This drug delivery system uses radially oriented mesoporous silica nanoparticles as the drug carrier, and control of the surface chemistry of those nanocarriers allows high-capacity loading efficiency of target drugs and stimuli-responsive release kinetics governed by pH and temperature.

Enhancing the evanescent field in TiO/Au hybrid thin films creates a highly sensitive room-temperature formaldehyde gas biosensor.

Discovery of the relationship between disease and the volatile organic compounds (VOCs) contained in respiratory gas in human bodies has led to the development of analytical methods and detection systems that can be used for diagnosis. Recent studies, however, have encountered problems using these diagnostic tools when operation temperatures are too high and the detection range of the gas concentration falls beyond the limits of diagnosis criteria. In this study, we propose a highly sensitive surface plasmon resonance (SPR) biosensor that is based on an enhanced evanescent wave technique and can be operated at room temperature (RT) for the detection of formaldehyde.

Novel color filters for the correction of red-green color vision deficiency based on the localized surface plasmon resonance effect of Au nanoparticles.

Color filters are promising tools for the correction of color vision deficiency because a medical cure of this physiological deficiency is unattainable. After the introduction of organic-dye based color filters, however, no appreciable progress has been made. In this study, gold nanoparticle-based plasmonic color filter devices, that is, EyEye-lens and EyEye-film, were developed for the correction of color vision deficiency.

Sensitive Detection of Formaldehyde Gas Using Modified Dandelion-Like SiO₂/Au Film and Surface Plasmon Resonance System.

To address the demands for the sensitive and real-time detection of formaldehyde gas at ambient temperature, a surface plasmon resonance (SPR) sensing system based on modified dandelion-like SiO₂ nanoparticles/Au thin film is developed. The sensing system relies on modified SiO₂ nanoparticles having radially arranged mesopores on the Au thin film, providing well-distributed and specific binding sites for formaldehyde and amplifying the sensing SPR signal. The linear range for the quantification is 0.

A combined top-down/bottom-up approach to structuring multi-sensing zones on a thin film and the application to SPR sensors.

The development of a thin film with well-defined metallic micro/nanostructures, diverse surface functionalities, and superior electronic/optical properties has been a great challenge to researchers seeking an efficient method for the detection of various analytes in chemical and biological sensing applications. Herein, we report a facile and effective approach to the fabrication of an ordered gold island pattern on a glass substrate with contrasted chemical functionalities, which can provide spatially separated sensing zones for multi-detection. In the proposed method, the combination between the micro/nano-imprint lithography and sequential self-assembly approaches exhibited synergistic effects that allowed well-defined structuring and easy surface functionalization in separated sensing zones.

Sensitive and selective analysis of a wide concentration range of IGFBP7 using a surface plasmon resonance biosensor.

A sensitive method for selectively detecting insulin-like growth factor-binding protein 7 (IGFBP7) over a wide range of concentrations based on the surface plasmon resonance (SPR) biosensing techniques is described. IGFBP7 has been shown to regulate cell proliferation, cell adhesion, cellular senescence, apoptosis, and angiogenesis in several different cancer cell lines. Since the concentration of IGFBP7 can vary widely in the body, determining the precise concentration of IGFBP7 over a wide range of concentrations is important, since it serves as an inducible biomarker for both disease diagnosis and subsequent therapy.

Effects of catalyst pore structure and acid properties on the dehydration of glycerol.

Hierarchical porous catalysts have recently attracted increasing interest because of the enhanced accessibility to active sites on such materials. In this context, previously reported hierarchically mesoporous ASN and ASPN materials are evaluated by applying them to the dehydration of glycerol, and demonstrate excellent catalytic performance. In addition, a comprehensive understanding of the effects of pore structures and the acid properties on the reaction through comparative studies with microporous HZSM-5 and mesoporous AlMCM-41 is provided.

A facile approach for the preparation of tunable acid nano-catalysts with a hierarchically mesoporous structure.

A facile and efficient approach to prepare hierarchically and radially mesoporous nano-catalysts with tunable acidic properties has been successfully developed. The nanospheres show excellent catalytic performance for the acid catalysed reactions, i.e.

Mesoporous siliconiobium phosphate as a pure Brønsted acid catalyst with excellent performance for the dehydration of glycerol to acrolein.

The development of solid acid catalysts that contain a high density of Brønsted acid sites with suitable acidity, as well as a long lifetime, is one of great challenges for the efficient dehydration of glycerol to acrolein. Herein, we report on a mesoporous siliconiobium phosphate (NbPSi-0.5) composite, which is a promising solid Brønsted acid that is a potential candidate for such a high-performance catalyst.