Publications by authors named "Youngberg J"

The effects of indomethacin on A/J mice were investigated. The non-steroidal antiinflammatory drug (NSAID) indomethacin reduced significantly the number of lung adenomas 3, 4 or 8 months after urethane injection by 28, 30 and 29% respectively. The density of apoptotic cell bodies increased 2.

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Objective: To clarify the role of anticoagulation with heparin and protamine reversal on the effectiveness of heparin bonding or coating of pulmonary artery catheters in preventing thrombus formation in the Rhesus monkey.

Design: A controlled, unblinded, open-labeled study.

Setting: A research laboratory at Tulane School of Medicine (New Orleans, LA).

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Objective: To investigate the cause of clot formation on the surface of non-heparin coated/bonded pulmonary artery catheters.

Design: A controlled, unblinded, open-labeled study.

Setting: Research laboratory at Tulane School of Medicine, New Orleans, LA.

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Pneumothorax may be a medical emergency. Iatrogenic pneumothorax is more common than all other forms of spontaneous pneumothorax, and surgical procedures involving the breast are a frequent setting for this. A 32-year-old, 60 kg, woman without any significant medical history underwent a bilateral breast augmentation and rhinoplasty.

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Previous studies have shown that the generation of cytotoxic T lymphocytes (CTL) following allogeneic tumor challenge is suppressed in Ah-responsive C57Bl/6 mice treated with a single oral dose of the toxic, Ah receptor-binding 3,4,5,3',4',5'-hexachlorobiphenyl (HxCB). The present studies have examined the specific role of the Ah receptor in this immunotoxic response by utilizing HxCB isomers of known, varied affinity for the Ah receptor as well as by comparing effects of high-affinity Ah receptor ligands (3,4,5,3',4',5'-HxCB and 2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD]) on the CTL response of mice that differ only at the Ah locus, that is, Ah-responsive (Ahbb) and Ah-nonresponsive (Ahdd) congenic C57Bl/6 mice. Correlative changes in thymic weight, serum corticosterone (CS) levels, and spleen cellularity were also measured.

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We have described a patient in whom tracheal rupture occurred during prolonged mechanical ventilation. Appropriate intensive respiratory care management, including the use of the minimal leak technique, was used. Our patient unfortunately had nearly every known predisposing factor for tracheal damage.

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The Conchatherm III is a servo-controlled, easily assembled heated humidifier. We studied its effectiveness in preventing intraoperative fall in temperature in both pediatric and adult surgical patients. Despite operating room temperatures lower than 69.

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The Renal Transplant Team at Tulane University Medical Center has been involved in training a multispecialty group of Guatemalan physicians to perform renal transplantations in Guatemala. The purpose is to train the physicians in their own country, using available equipment and personnel so that they can perform successful operations in our absence. This paper is a review of the considerations involved in the initial renal transplantation done in Guatemala by the Tulane Renal Transplant Team.

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A review of publications from various countries, using the Bain system with a fresh gas flow of 70 ml kg-1 min-1 and controlled ventilation, show a range of mean PaCO2 values between 36 and 43 mmHg. It was suggested that these differences could be related to the geographic location of the patient population studied. Anaesthetists from seven institutions in West Germany, England, Sweden, the United States, Australia and Canada collaborated in a preliminary study designed to find out whether these differences could be reduplicated.

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We administered lidocaine intravenously or topically to the larynx to compare the cardiovascular response to intubation between the two techniques and to determine if these responses were related to blood levels of lidocaine. Sixteen patients were randomly selected into group A (100 mg intravenous lidocaine) or group B (160 mg topical lidocaine). Neither method was completely effective in abolishing hypertension and tachycardia on intubation.

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The use of pulmonary artery catheters in assessing and managing critically ill patients has become a common practice. The risks associated with insertion of the Swan-Ganz catheter via the internal jugular or subclavian vein include pneumothorax, puncture of the carotid or subclavian artery, mediastinal infiltration, and neurologic damage. I evaluated the success and complication rates associated with placement of a pulmonary artery catheter via the external jugular vein in 25 unselected consecutive patients.

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The physical stress on the rescuer performing cardiopulmonary resuscitation (CPR) was assessed utilizing the ECG, rate pressure product (RPP), and total body oxygen consumption (VO2). Six healthy physicians served as rescuers. Only a submaximal physical effort was required to perform good CPR, as demonstrated by the heart rate and VO2 changes.

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