Publications by authors named "Young-Mog Shim"
Importance: Emerging evidence suggests that wearable devices are feasible for monitoring physical activity among patients with lung cancer. However, the association between wearable devices and improvement in patient recovery after surgery remains underexplored.
Objective: To evaluate the effects of a wearable device intervention on the recovery of physical activity, cardiopulmonary function, and health-related quality of life (HRQOL) after lung cancer surgery.
Article Synopsis
- Neoadjuvant chemoradiotherapy (nCRT) before surgery is the main treatment for locally advanced esophageal squamous cell cancer, with three regimens compared for effectiveness and safety in patients treated between 2016 and 2022.
- Overall survival rates were best with the CROSS regimen, showing 88.1% at one year, while pathologic complete response (pCR) rates were similar across all regimens.
- Grade 3 toxicities varied by regimen, with the CROSS group experiencing the least adverse effects and weight loss, suggesting it may be the preferable option for treatment.
Article Synopsis
- * A total of 680 patients were analyzed, and after balancing confounding factors through propensity score matching, key outcomes like lymph node dissection and survival rates were compared.
- * Results indicated that both techniques yielded similar overall survival rates and oncological outcomes, suggesting they are both viable options for treating mid-to-lower ESCC.
Purpose: There is few evidence regarding the optimal salvage treatment options for loco-reginal recurrence of esophageal cancer. This study aimed to evaluate the clinical outcomes of salvage radiotherapy (RT) in patients with loco-regional recurrence (LRR) after surgery for esophageal cancer.
Materials And Methods: We retrospectively reviewed 147 esophageal cancer patients who received salvage RT for loco-regional recurrence between 1996 and December 2019.
Objectives: The use of tumor-informed circulating tumor DNA (ctDNA) testing in patients with early-stage disease before surgery is limited, mainly owing to restricted tissue access and extended turnaround times. This study aimed to evaluate the clinical value of a tumor-naïve, methylation-based cell-free DNA assay in a large cohort of patients with resected NSCLC.
Method: We analyzed presurgical plasma samples from 895 patients with EGFR and anaplastic lymphoma kinase-wild-type, clinical stage I or II NSCLC.
Article Synopsis
- This study looked at patients with oesophageal squamous cell carcinoma who couldn't or chose not to have surgery after receiving neoadjuvant chemoradiotherapy (nCRT).
- Of the 715 patients analyzed, 105 (14.7%) didn't undergo surgery, with reasons including disease progression, functional decline, or patient refusal.
- Results showed that patients who refused surgery had significantly worse recurrence-free survival (RFS) rates compared to those who had surgery, especially if they had a partial or stable response to treatment, although overall survival (OS) rates were not significantly different between the two groups.
Article Synopsis
- Occult lymph node metastasis (OLNM) is common in patients with resectable non-small cell lung cancer (NSCLC), despite following established diagnostic guidelines.
- The study evaluated the risk of OLNM based on specific radiologic characteristics of primary tumors as seen on CT scans in a retrospective analysis of 2042 NSCLC patients.
- Findings revealed that certain tumor features, such as endobronchial location, significantly increased the risk of OLNM, while others, like heterogeneous ground-glass opacity, had a lower risk, helping clinicians better determine the need for invasive nodal staging.
Article Synopsis
- The study evaluated the effectiveness and safety of adjuvant pembrolizumab in patients with stage IIIA/N2 non-small cell lung cancer (NSCLC) who underwent prior neoadjuvant chemoradiation therapy and complete surgical resection.
- Findings showed a median disease-free survival (DFS) of 22.4 months and a 5-year DFS rate of 29%, indicating pembrolizumab may help control the disease long-term for some patients.
- Despite some patients experiencing tumor recurrence, no new safety concerns were observed, suggesting that pembrolizumab could be a viable treatment option post-surgery for specific NSCLC patients.
Purpose: Lung cancer survivors have more psychosocial problems, including depression and anxiety disorder, than other cancer survivors. Lung cancer-specific symptoms, such as cough, dyspnea, or pain in chest, might increase FCR among survivors. We aimed to evaluate the association between lung cancer-specific symptoms and FCR among recurrence-free non-small cell lung cancer (NSCLC) survivors.
View Article and Find Full Text PDFBackground: We aimed to identify the impact of muscle mass on locally advanced oesophageal cancer (LAEC) in elderly patients receiving neoadjuvant chemoradiation therapy (NACRT).
Methods: We reviewed the medical records of 345 patients diagnosed with LAEC who underwent NACRT and surgery. Physical variables, including height, weight, skeletal muscle mass, and laboratory values, were obtained before and after NACRT.
Article Synopsis
- The study examines the risks of complications following major lung surgery after neoadjuvant concurrent chemoradiation therapy in patients with stage IIIA-N2 non-small cell lung cancer.
- It reveals that patients over 70 years old, those with low body mass index, and those undergoing pneumonectomy face significantly higher rates of morbidity and mortality post-surgery.
- The findings suggest that alternative treatments may be more suitable for high-risk patients, particularly the elderly or those with poorer lung function, rather than pursuing surgical options.
Article Synopsis
- Recent research highlights the importance of novel transcriptional factor-based molecular subtypes in predicting outcomes for small-cell lung cancer (SCLC) patients through in-depth analysis of multi-omics data combined with immunohistochemistry (IHC).
- The study involved a comprehensive examination of data from 427 SCLC patients, focusing on mutation profiles, gene expression, and inflammation signatures, revealing distinct molecular subtypes and their clinical outcomes.
- Findings showed significant differences in survival rates among subtypes, with the ASCL1 subtype exhibiting the most favorable overall survival, and inflamed tumors being more responsive to immunotherapy compared to non-inflamed tumors.
Introduction: Few studies have evaluated the effectiveness of interventions for distress during cancer diagnosis on clinical outcomes in a real-world setting. We aimed to evaluate whether routine information and psychosocial support to patients experiencing distress at the time of diagnosis could decrease the risk of mortality within 1 and 3 years after diagnosis.
Material And Methods: We conducted a retrospective cohort study of 4880 newly diagnosed cancer patients who reported distress scores of ≥4 using the tablet or kiosk-based screening between July 2014 and December 2017 at a university-affiliated cancer center in Seoul, South Korea.
Article Synopsis
- * Out of 810 patients, 19.6% experienced PPCs, with those in the low lung function groups having a significantly higher relative risk (RR) for developing these complications compared to those with better lung function.
- * The findings suggest that poor preoperative lung function increases the risk of PPCs after esophagectomy, especially when both FEV and DLco levels are low.
Article Synopsis
- Lung cancer diagnostic guidelines recommend invasive mediastinal nodal staging (IMNS), but its effectiveness on survival in non-small cell lung cancer (NSCLC) patients without lymph node metastasis (rN0) remains unclear.
- A study compared long-term survival rates between NSCLC patients who underwent IMNS and those who did not, using data from the Samsung Medical Centre from 2008 to 2016.
- Results showed no significant survival difference; both groups had similar 5-year overall survival rates (73.9% for IMNS vs. 71.7% for non-IMNS) and recurrence-free survival rates, despite a 7.2% incidence of unexpected metastasis in the IMNS group.
Background: Lung cancer diagnosis affects an individual's quality of life as well as physical and emotional functioning. Information on survivorship care tends to be introduced at the end of treatment, but early intervention may affect posttreatment adjustment. However, to the best of our knowledge, no study has explored the effect of early information intervention on the return to work, family, and societal roles of lung cancer survivors.
View Article and Find Full Text PDFArticle Synopsis
- Esophageal squamous cell carcinoma (ESCC) patients with liver cirrhosis (LC) show worse postoperative and long-term survival outcomes compared to those without LC.
- In a study of 121 LC patients and 2810 non-LC patients who underwent surgery, those with LC experienced longer operation times, higher blood loss, and increased morbidity and mortality rates.
- Child-Pugh class A LC significantly impacts overall survival, suggesting the need for careful patient selection and postoperative management for individuals with LC undergoing esophagectomy.
Article Synopsis
- This study reviews cases of patients who underwent contralateral lung resection following a pneumonectomy over a 26-year period, providing insights into the challenges and outcomes of this procedure.
- A total of 13 patients participated, with a median age of 57 and a variety of surgical interventions performed, mainly wedge resections.
- The results indicate that complications were common but manageable, showing that this type of surgery can be safely performed in well-selected patients.
Article Synopsis
- The study investigates the expression of PD-L1, a biomarker for immunotherapy, in lung adenocarcinoma and how it relates to a new grading system for tumors.
- In a cohort of 1,233 patients, PD-L1 positivity was found to increase with tumor grade: 7% in G1, 23.5% in G2, and 63% in G3 tumors.
- PD-L1 was linked to worse patient outcomes, being an independent risk factor for recurrence and death in G2 tumors, but not significantly in G3 tumors.
Article Synopsis
- The study introduces a new ypTNM grouping system to enhance prognostic accuracy for patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemoradiotherapy (nCRT) and surgery.
- It critiques the existing AJCC 8th edition ypStage system for its poor prognostic relevance and develops a revised system using data from 923 ESCC patients treated in two medical centers.
- The new classification shows improved survival discrimination and addresses the limitations of the old system, resulting in better patient stratification outcomes.
Article Synopsis
- This study evaluated treatment outcomes for patients with recurrent stage I non-small cell lung cancer (NSCLC) who previously had part of their lung removed (sublobar resection) and later underwent completion lobectomy (CL).
- Out of 36 patients analyzed, those who underwent CL had significantly better overall survival (OS) and post-recurrence survival (PRS) compared to those who received non-surgical treatments or no treatment.
- The research concludes that while CL is a complex but safe procedure, further studies with larger groups and longer follow-up are needed to validate these findings.
Article Synopsis
- - The study analyzed 3,096 esophageal cancer patients who underwent esophagectomy between 2003 and 2020, focusing on the 181 (5.8%) who experienced anastomotic leakage (AL), with a higher incidence in cervical anastomosis (11.9%) compared to intrathoracic anastomosis (3.2%).
- - Treatment methods for AL included nothing-by-mouth (NPO) restrictions, endoscopic vacuum therapy (EVT), and surgical repairs, with over 90% of cervical AL patients able to resume oral diets by discharge, regardless of treatment, while success for TA patients varied more significantly by treatment type.
- - Despite more cervical AL cases, patients