The potential anti-amyloidogenic candidate, SPA1413, for Alzheimer's disease.

Background And Purpose: Recently, isoflavone derivatives have been shown to have neuroprotective effects against neurological disorders. For instance, genistein attenuated the neuroinflammation and amyloid-β accumulation in Alzheimer's disease animal models, suggesting the potential for use to prevent and treat Alzheimer's disease.

Experimental Approach: Here, 50 compounds, including isoflavone derivatives, were constructed and screened for the inhibitory effects on amyloid-β fibrilization and oligomerization using the high-throughput screening formats of thioflavin T assay and multimer detection system, respectively.

Monitoring of air pollution by polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans of pine needles in Korea.

The atmospheric contamination levels of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) were evaluated from the analysis of pine needles in South Korea. Pine needles were collected from 30 sampling points at five main cities in South Korea (Busan, Daegu, Gwangju, Changwon and Jeju island). The highest concentrations of PCDDs/DFs (2.