Protective efficacy of attenuated Typhimurium strain expressing BLS, Omp19, PrpA, or SOD of in goats.

Background: Attenuated strain can be used as a vector to transport immunogens to the host antigen-binding sites.

Objectives: The study aimed to determine the protective efficacy of attenuated strain expressing highly conserved immunogens in goats.

Methods: Goats were vaccinated with vector expressing individually lipoprotein outer-membrane protein 19 (Omp19), lumazine synthase (BLS), proline racemase subunit A (PrpA), Cu/Zn superoxide dismutase (SOD) at 5 × 10⁹ CFU/mL and challenge of all groups was done at 6 weeks after vaccination.

Disparities in gastric cancer screening among people with disabilities: a national registry-linkage study in South Korea.

Background And Aim: Using the national disability registration linked to the cancer screening database in Korea, we examined (1) trends in the gastric cancer screening rate among people with disabilities over time, and (2) whether gastric cancer screening participation and modalities differed according to presence, severity, and type of disability.

Methods: We examined gastric cancer screening participation rates among individuals with registered disability, from 2006 to 2015.

Results: The age- and sex-adjusted rate for gastric cancer screening in people with disabilities increased from 25.

Vaccination of goats with a combination vector expressing four antigens (BLS, PrpA, Omp19, and SOD) confers protection against infection.

is an intracellular pathogen with a cellular infection mechanism similar to that of , making it a suitable choice for use in an anti- immune boost system. This study explores the efficacy of a Typhimurium delivery-based combination vaccine for four heterologous antigens ( lumazine synthase, proline racemase subunit A, outer-membrane protein 19, and Cu/Zn superoxide dismutase) targeting brucellosis in goats. We inoculated the attenuated delivery-based vaccine combination subcutaneously at two different inoculation levels; 5 × 10 colony-forming unit (CFU)/mL (Group B) and 5 × 10 CFU/mL (Group C) and challenged the inoculations with virulent at 6 weeks post-immunization.

Four Years Prospective Study of Natural History of Atopic Dermatitis Aged 7~8 Years at an Individual Level: A Community-Based Survey by Dermatologists' Skin Examination in Childhood.

Background: The age-dependent change in atopic dermatitis (AD) at an individual level has mostly performed in a hospital-setting.

Objective: We evaluated the age-dependent change of AD symptoms at an individual level in a community-setting.

Methods: For the diagnostic accuracy, all participants of schoolchildren were received skin examination by dermatologists (twice a year for the same group), instead of questionnaire-based surveys.

Pulmonary diffusing capacity in healthy African-American and Caucasian children.

Previous studies of pulmonary diffusing capacity in healthy children primarily focused upon Caucasian (C) subjects. Since lung volumes in African-Americans (AA) are smaller than lung volumes in C subjects of the same height, diffusing capacity values in AA children might be interpreted as low or abnormal using currently available equations without adjusting for race. Healthy AA (N = 151) and C (N = 301) children between 5 and 18 years of age performed acceptable measurements of single breath pulmonary diffusing capacity for carbon monoxide (DLCO ) and alveolar volume (VA ) according to current ATS/ERS guidelines.

Amelanotic Acral Melanoma Associated with KIT Mutation and Vitiligo.

Amelanotic acral melanoma is rare and difficult to diagnose, both clinically and pathologically. KIT mutations are frequently found in acral melanomas and are considered a risk factor for poor prognosis. The presence of vitiligo in melanoma has been reported, and KIT is thought to be partly responsible for the dysfunction and loss of melanocytes observed in vitiligo.

Ethanol Extract of Peanut Sprout Exhibits a Potent Anti-Inflammatory Activity in Both an Oxazolone-Induced Contact Dermatitis Mouse Model and Compound 48/80-Treated HaCaT Cells.

Background: We developed an ethanol extract of peanut sprouts (EPS), a peanut sprout-derived natural product, which contains a high level of trans-resveratrol (176.75 µg/ml) and was shown to have potent antioxidant activity.

Objective: We evaluated the potential anti-inflammatory activity of EPS by measuring its antioxidant potential in skin.

Propranolol in the treatment of upper airway hemangiomas.

Airway hemangiomas (AHs), which are common in infant airways, often cause significant upper airway obstruction. The various therapies used for AH have limitations and complications. Propranolol may have a potential role in its treatment, since it leads to regression or stabilization of cutaneous infantile hemangiomas.

Relationship between Blood Stasis Syndrome Score and Cardioankle Vascular Index in Stroke Patients.

Blood stasis syndrome (BSS) in traditional Asian medicine has been considered to correlate with the extent of atherosclerosis, which can be estimated using the cardioankle vascular index (CAVI). Here, the diagnostic utility of CAVI in predicting BSS was examined. The BSS scores and CAVI were measured in 140 stroke patients and evaluated with respect to stroke risk factors.

Effects of Hyul-Bu-Chuke-Tang on Erythrocyte Deformability and Cerebrovascular CO(2) Reactivity in Normal Subjects.

Aim. Hyul-bu-chuke-tang (HCEt) is a well-known traditional herbal medicine that is used for the treatment of ischemic cerebrovascular disorders. We investigated the acute effects of HCEt on erythrocyte deformability and cerebrovascular CO(2) reactivity (CVR) in healthy male subjects.

Uhwang Chungsim Won decreases blood oxygen level-dependent fMRI signal response to a motor stimulation task.

Objectives: To evaluate the effect of Uhwang Chungsim Won [UC, Niuhuang Qingxin Pill ()] on the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal response to a motor stimulation task using a hand grasping paradigm.

Methods: Ten healthy right-handed male volunteers were recruited. Their BOLD fMRI signal characteristics during hand grasping were determined before and 1 h after consuming UC.

Lung function before and after pediatric allogeneic hematopoietic stem cell transplantation: a predictive role for DLCOa/VA.

Background: Pre-allogeneic hematopoietic stem cell transplantation (aHSCT) and post-aHSCT lung function of 41 eligible patients at Riley Hospital for Children were assessed to identify risk factors for post-aHSCT morbidity and mortality.

Observations: One year post-aHSCT pulmonary function tests were significantly lower compared with baseline. These findings recovered at 2 years post-aHSCT.

Pulmonary diffusing capacity in healthy Caucasian children.

Previous studies of pulmonary diffusing capacity in children differed greatly in methodologies; numbers of subjects evaluated, and were performed prior to the latest ATS/ERS guidelines. The purpose of our study was to establish reference ranges for the diffusing capacity to carbon monoxide (DL(CO) ) and alveolar volume (V(A) ) in healthy Caucasian children using current international guidelines and contemporary equipment. Healthy children from the United States (N = 303) and from Australia (N = 176) performed acceptable measurements of single breath pulmonary diffusing capacity and alveolar volume according to current ATS/ERS guidelines.

Outcome of palliative self-expanding metal stent placement in malignant colorectal obstruction according to stent type and manufacturer.

Background: Self-expandable metallic stents (SEMS) of varying designs and materials have been developed to reduce complications, but few comparative data are available with regard to the type of stent and the stent manufacturer. We analyzed the success rates and complication rates, according to stent type (uncovered vs. covered stent) and individual stent manufacturer, in malignant colorectal obstruction.

[A case of steroid resistant autoimmune hemolytic anemia in ulcerative colitis].

Autoimmunity is thought to play a central role in the pathogenesis of inflammatory bowel disease and associated extraintestinal manifestations. Autoimmune hemolytic anemia associated with ulcerative colitis is a rare occurrence. No more than 50 cases have been described in the international literatures, and only 2 cases reported in Korea.

Pulmonary function in bronchopulmonary dysplasia.

The purpose of this study was to examine lung function and bronchodilator responsiveness in infants with a history of prematurity and bronchopulmonary dysplasia (BPD), using the raised volume rapid thoracoabdominal compression technique as well as with whole-body plethysmography. Spirometric measurements were obtained in 28 infants with a history of BPD, defined as preterm birth with O2 requirement at 36 weeks postmenstrual age (gestational age at birth, 26.4 +/- 2.