Publications by authors named "Young Yoon Bang"
Background: Dabigatran etexilate (DABE), a prodrug of dabigatran (DAB), is a direct thrombin inhibitor used to prevent ischemic stroke and thromboembolism during atrial fibrillation. The effect of genetic polymorphisms on its metabolism, particularly , has not been extensively explored in humans. This study aimed to investigate the effects of , , and polymorphisms on the pharmacokinetics of DAB and its acylglucuronide metabolites in healthy subjects.
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- A study on β-amanitin, a toxic compound in certain mushrooms, showed that when administered to mice, its plasma concentration increased with higher doses, with a rapid clearance from the system, having a half-life of about 18-34 minutes.
- After intravenous (iv) administration, a significant portion of the compound remained unchanged in the bloodstream, while oral administration resulted in low bioavailability and high fecal recovery.
- The compound primarily concentrated in organs like the intestine, kidneys, and liver, aligning with known effects of amatoxin poisoning, and also showed minimal interaction with major liver enzymes, suggesting it might have limited drug interaction effects.