Thyroid hormone-regulated chromatin landscape and transcriptional sensitivity of the pituitary gland.

Thyroid hormone (3,5,3'-triiodothyronine, T3) is a key regulator of pituitary gland function. The response to T3 is thought to hinge crucially on interactions of nuclear T3 receptors with enhancers but these sites in pituitary chromatin remain surprisingly obscure. Here, we investigate genome-wide receptor binding in mice using tagged endogenous thyroid hormone receptor β (TRβ) and analyze T3-regulated open chromatin using an anterior pituitary-specific Cre driver (Thrb).

Transcriptional control of cone photoreceptor diversity by a thyroid hormone receptor.

Cone photoreceptor diversity allows detection of wavelength information in light, the first step in color (chromatic) vision. In most mammals, cones express opsin photopigments for sensitivity to medium/long (M, "green") or short (S, "blue") wavelengths and are differentially arrayed over the retina. Cones appear early in retinal neurogenesis but little is understood of the subsequent control of diversity of these postmitotic neurons, because cone populations are sparse and, apart from opsins, poorly defined.

Entangling three identical particles via spatial overlap.

Quantum correlations between identical particles are at the heart of quantum technologies. Several studies with two identical particles have shown that the spatial overlap and indistinguishability between the particles are necessary for generating bipartite entanglement. On the other hand, researches on the extension to more than two-particle systems are limited by the practical difficulty to control multiple identical particles in laboratories.

Demonstration of Complete Information Trade-Off in Quantum Measurement.

While an information-disturbance trade-off in quantum measurement has been at the core of foundational quantum physics and constitutes a basis of secure quantum information processing, recently verified reversibility of a quantum measurement requires to refine it toward a complete version of information trade-off in quantum measurement. Here we experimentally demonstrate a trade-off relation among all information contents, i.e.

Sub-10 nm Precision Engineering of Solid-State Defects via Nanoscale Aperture Array Mask.

Engineering a strongly interacting uniform qubit cluster would be a major step toward realizing a scalable quantum system for quantum sensing and a node-based qubit register. For a solid-state system that uses a defect as a qubit, various methods to precisely position defects have been developed, yet the large-scale fabrication of qubits within the strong coupling regime at room temperature continues to be a challenge. In this work, we generate nitrogen vacancy (NV) color centers in diamond with sub-10 nm scale precision using a combination of nanoscale aperture arrays (NAAs) with a high aspect ratio of 10 and a secondary E-beam hole pattern used as an ion-blocking mask.

Comparison of precutting endoscopic mucosal resection and endoscopic submucosal dissection for large (20-30 mm) flat colorectal lesions.

Background And Aim: The complete and safe removal of large (≥ 20 mm) colorectal lesions is an area of concern. Endoscopic submucosal dissection (ESD) effectively removes these lesions compared with endoscopic mucosal resection (EMR). However, ESD requires advanced techniques, longer procedure time, and high cost.

Screening Leads to Overestimated Associations of Thyroid Dysfunction and Thyroiditis with Thyroid Cancer Risk.

We aimed to assess the relationships of functional thyroid disease and thyroiditis with subsequent thyroid cancer, which is controversial due to various confounders, and the effect of thyroid disease workup on this association. We used the cohort data from 2002 to 2015 (Study I, = 28,330) and the entire data from 2002 to 2019 (Study II, = 883,074) of the Korean National Health Insurance Service database, and performed logistic regression and subgroup analyses with various covariates. In Study I, hypothyroidism, thyroiditis, autoimmune thyroiditis, hyperthyroidism, and Graves' disease showed positive associations with thyroid cancer.

Implementation of a 3 × 3 directionally-unbiased linear optical multiport.

Linear optical multiports are widely used in photonic quantum information processing. Naturally, these devices are directionally-biased since photons always propagate from the input ports toward the output ports. Recently, the concept of directionally-unbiased linear optical multiports was proposed.

Quantum enhanced multiple-phase estimation with multi-mode N00N states.

Quantum metrology can achieve enhanced sensitivity for estimating unknown parameters beyond the standard quantum limit. Recently, multiple-phase estimation exploiting quantum resources has attracted intensive interest for its applications in quantum imaging and sensor networks. For multiple-phase estimation, the amount of enhanced sensitivity is dependent on quantum probe states, and multi-mode N00N states are known to be a key resource for this.

A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver.

Thyroid hormones (THs) are powerful regulators of metabolism with major effects on body weight, cholesterol, and liver fat that have been exploited pharmacologically for many years. Activation of gene expression by TH action is canonically ascribed to a hormone-dependent "switch" from corepressor to activator binding to thyroid hormone receptors (TRs), while the mechanism of TH-dependent repression is controversial. To address this, we generated a mouse line in which endogenous TRβ1 was epitope-tagged to allow precise chromatin immunoprecipitation at the low physiological levels of TR and defined high-confidence binding sites where TRs functioned at enhancers regulated in the same direction as the nearest gene in a TRβ-dependent manner.

Entangling bosons through particle indistinguishability and spatial overlap.

Particle identity and entanglement are two fundamental quantum properties that work as major resources for various quantum information tasks. However, it is still a challenging problem to understand the correlation of the two properties in the same system. While recent theoretical studies have shown that the spatial overlap between identical particles is necessary for nontrivial entanglement, the exact role of particle indistinguishability in the entanglement of identical particles has never been analyzed quantitatively before.

Diamond photonic crystal mirror with a partial bandgap by two 2D photonic crystal layers.

In this study, photonic crystals with a partial bandgap are demonstrated in the visible region using single-crystal diamonds. Quasi-three-dimensional photonic crystal structures are fabricated in the surface of the single-crystal diamonds using a tetrahedron Faraday cage that enables angled dry etching in three directions simultaneously. The reflection spectra can be controlled by varying the lattice constant of the photonic crystals.

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.

Transcription factors C/EBPβ and C/EBPδ are induced within hours after initiation of adipogenesis in culture. They directly promote the expression of master adipogenic transcription factors peroxisome proliferator-activated receptor γ (PPARγ) and C/EBPα and are required for adipogenesis However, the mechanism that controls the induction of C/EBPβ and C/EBPδ remains elusive. We previously showed that histone methyltransferases MLL3/MLL4 and associated PTIP are required for the induction of PPARγ and C/EBPα during adipogenesis.

Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound.

The detection of different frequencies in sound is accomplished with remarkable precision by the basilar membrane (BM), an elastic, ribbon-like structure with graded stiffness along the cochlear spiral. Sound stimulates a wave of displacement along the BM with maximal magnitude at precise, frequency-specific locations to excite neural signals that carry frequency information to the brain. Perceptual frequency discrimination requires fine resolution of this frequency map, but little is known of the intrinsic molecular features that demarcate the place of response on the BM.

Universal Compressive Characterization of Quantum Dynamics.

Recent quantum technologies utilize complex multidimensional processes that govern the dynamics of quantum systems. We develop an adaptive diagonal-element-probing compression technique that feasibly characterizes any unknown quantum processes using much fewer measurements compared to conventional methods. This technique utilizes compressive projective measurements that are generalizable to an arbitrary number of subsystems.

H2B ubiquitylation enhances H3K4 methylation activities of human KMT2 family complexes.

In mammalian cells, distinct H3K4 methylation states are created by deposition of methyl groups by multiple complexes of histone lysine methyltransferase 2 (KMT2) family proteins. For comprehensive analyses that directly compare the catalytic properties of all six human KMT2 complexes, we employed a biochemically defined system reconstituted with recombinant KMT2 core complexes (KMT2CoreCs) containing minimal components required for nucleosomal H3K4 methylation activity. We found that each KMT2CoreC generates distinct states and different levels of H3K4 methylation, and except for MLL3 all are stimulated by H2Bub.

Reference-frame-independent, measurement-device-independent quantum key distribution using fewer quantum states.

Reference-frame-independent quantum key distribution (RFI-QKD) provides a practical way to generate secret keys between two remote parties without sharing common reference frames. On the other hand, measurement-device-independent QKD (MDI-QKD) offers a high level of security, as it is immune to all quantum hacking attempts to measurement devices. The combination of these two QKD protocols, i.

Informationally symmetrical Bell state preparation and measurement.

Bell state measurement (BSM) plays crucial roles in photonic quantum information processing. The standard linear optical BSM is based on Hong-Ou-Mandel interference where two photons meet and interfere at a beamsplitter (BS). However, a generalized two-photon interference is not based on photon-photon interaction, but interference between two-photon probability amplitudes.

Publisher Correction: Direct quantum process tomography via measuring sequential weak values of incompatible observables.

In the original version of this Article, the penultimate sentence of the second paragraph of the "Schematic and theory" section of the Results originally incorrectly read as "For instance, choosing θ = π/4, 0, -π/8 and π/8 rotates the bases |0>, |1>, |+>, and |-> into |1>, thereby implementing the observableÂ=|0><0|, |1><1|, |+><+| and, respectively." In the corrected version, "|-><-|" has been added before ", respectively". This error has been corrected in both the PDF and HTML versions of the Article.

Direct quantum process tomography via measuring sequential weak values of incompatible observables.

The weak value concept has enabled fundamental studies of quantum measurement and, recently, found potential applications in quantum and classical metrology. However, most weak value experiments reported to date do not require quantum mechanical descriptions, as they only exploit the classical wave nature of the physical systems. In this work, we demonstrate measurement of the sequential weak value of two incompatible observables by making use of two-photon quantum interference so that the results can only be explained quantum physically.

Limits on manipulating conditional photon statistics via interference of weak lasers.

Photon anti-bunching, measured via the Hanbury-Brown-Twiss experiment, is one of the key signatures of quantum light and is tied to sub-Poissonian photon number statistics. Recently, it has been reported that photon anti-bunching or conditional sub-Poissonian photon number statistics can be obtained via second-order interference of mutually incoherent weak lasers and heralding based on photon counting [Phys. Rev.

Alterations in the bone marrow microenvironment may elicit defective hematopoiesis: a comparison of aplastic anemia, chronic myeloid leukemia, and normal bone marrow.

Hematopoiesis involves complex interactions between hematopoietic cells and the bone marrow (BM) microenvironment. The specific causes and mechanisms underlying dysregulated hematopoiesis are unknown. Here, BM biopsy specimens from patients with aplastic anemia (AA) and chronic myeloid leukemia (CML) and normal marrow were analyzed by semiquantitative immunohistochemistry to determine changes in the hematopoietic stem cell (HSC) compartment and BM microenvironment.