Publications by authors named "Young Son"

Superparamagnetic iron oxide nanoparticles (SPIONs) are promising contrast agents for imaging-guided cancer therapies. However, challenges such as the requirement for a high alternating magnetic field (AMF), dosage limitations, and suboptimal imaging contrast have hindered their practical applications. First, the optimal doping ratio of Mn and Zn in MnZnFeO nanoparticles synthesized using a modified high-temperature thermal decomposition method (mHTTD) was determined.

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Background: Skin wound healing is a complex process requiring coordinated cellular and molecular interactions. Polynucleotides (PN) and hyaluronic acid (HA) have emerged as promising agents in regenerative medicine due to their ability to enhance cellular proliferation, angiogenesis, and extracellular matrix (ECM) remodeling. Combining PN and HA offers potential synergistic effects, accelerating wound repair.

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Breast cancer is a highly heterogeneous disease; hence, it is crucial to understand its biology and identify new targets for the development of effective treatments. Galectin-1 is known to play an oncogenic role in breast cancer progression. It is known that oncogenic factors can influence cancer progression through interactions with miRNAs.

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Respiratory syncytial virus (RSV) causes symptoms similar to a mild cold for adults, but in case of infants, it causes bronchitis and/or pneumonia, and in some cases, mortality. Mucosal immunity within the respiratory tract includes tissue-resident memory T (T) cells and tissue-resident memory B (B) cells, which provides rapid and efficient protection against RSV re-infection. Therefore, vaccine strategies should aim to generate mucosal immune responses.

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Background: Acute tubular injury is one of the main causes of acute tubular injury (acute kidney injury ) in patients with COVID-19 infection. Autoimmune hemolytic anemia (AIHA) is also one of the autoimmune complications of COVID-19. However, AIHA accompanied by acute tubulointerstitial nephritis (ATIN) caused by SARS-CoV-2 is rarely reported.

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Introduction: Management of metastatic renal cell carcinoma (mRCC) is highly individualized and often involves cytoreductive nephrectomy (CN) and systemic therapy (ST). The optimal sequencing of CN and ST is uncertain. A difference in perioperative outcomes based on sequence of CN and ST could influence decisionmaking.

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Intermittent hypoxia (IH) has been extensively studied in recent years, demonstrating adverse and beneficial effects on several physiological systems. However, the precise mechanism underlying its cardiac effects on the heart remains unclear. This study aims to explore the effect of treatment on atrial fibrillation under IH conditions, providing data that can potentially be used in the treatment of heart disease.

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Mitochondrial homeostasis is controlled by biogenesis, dynamics, and mitophagy. Mitochondrial dysfunction plays a central role in cardiovascular and renal disease and omega-3 fatty acids (FAs) are beneficial for cardiovascular disease. We investigated whether omega-3 fatty acids (FAs) regulate mitochondrial biogenesis, dynamics, and mitophagy in the kidney and heart of adenine-induced uremic rats.

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The importance of the complex interplay between the microbiome and mucosal immunity, particularly within the respiratory tract, has gained significant attention due to its potential implications for the severity and progression of lung diseases. Therefore, this review summarizes the specific interactions through which the respiratory tract-specific microbiome influences mucosal immunity and ultimately impacts respiratory health. Furthermore, we discuss how the microbiome affects mucosal immunity, considering tissue-specific variations, and its capacity in respiratory diseases containing asthma, chronic obstructive pulmonary disease, and lung cancer.

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The long-term physiological consequences of respiratory viral infections, particularly in the aftermath of the COVID-19 pandemic-termed post-acute sequelae of SARS-CoV-2 (PASC)-are rapidly evolving into a major public health concern. While the cellular and molecular aetiologies of these sequelae are poorly defined, increasing evidence implicates abnormal immune responses and/or impaired organ recovery after infection. However, the precise mechanisms that link these processes in the context of PASC remain unclear.

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  • * The study involved placing PM sensors in key areas of the apartment, which activated air quality interventions when particulate matter (PM) levels exceeded 15 μg/m.
  • * Results showed that Advanced Control reduced PM concentrations by 40% overall, with a 20% reduction observed specifically in the kitchen, demonstrating the effectiveness of automated systems compared to manual interventions.
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  • Accurate depth information in endoscopy is critical for effective navigation, but space limitations make it hard to use depth cameras.
  • The study proposes a three-step process to estimate depth from endoscopic images using deep learning, starting with creating simulated images and depth maps using Unity.
  • The resulting depth estimation method shows improved accuracy compared to previous unsupervised approaches, offering potential benefits for navigation and clinical outcomes in endoscopy.
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  • * Recent studies show that ESM can significantly reduce joint pain and slow cartilage damage in animal models of OA when taken before and after inducing the condition.
  • * ESM appears to work by inhibiting inflammatory markers and enzymes that contribute to cartilage degradation, especially early in the disease's progression, but its effectiveness diminishes in later stages.
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Purpose: Accurate measurement of renal mass size is crucial in the management of renal cancer. With the burdensome cost of imaging yet its need for management, a better understanding of the variability among patients when determining mass size remains of urgent importance. Current guidelines on optimal imaging are limited, especially with respect to body mass index (BMI).

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Aims: To assess and compare 30-day perioperative adverse events following suburethral sling surgery using synthetic mesh, autologous rectus fascia, and autologous fascia lata in women.

Methods: This was a retrospective cohort study of patients who underwent fascial or synthetic sling placement for stress urinary incontinence between 2008 and 2021 using the American College of Surgeons' National Surgical Quality Improvement Program database. Current Procedural Terminology codes were used to identify patients undergoing each type of sling procedure.

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Foamy viruses (FVs) are generally recognized as non-pathogenic, often causing asymptomatic or mild symptoms in infections. Leveraging these unique characteristics, FV vectors hold significant promise for applications in gene therapy. This study introduces a novel platform technology using a pseudo-virus with single-round infectivity.

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Emerging studies have identified the critical roles of tissue-resident memory CD8+ T (TRM) and B (BRM) cells in the protection against mucosal viral infections, but the underlying mechanisms regulating robust development of TRM and BRM cells remain incompletely understood. We have recently shown that tissue-resident helper CD4+ T (TRH) cells, developed following influenza virus infection, function to sustain the optimal maintenance of TRM and BRM cells at the mucosal surface. In this study, we have explored the cellular and molecular cues modulating lung TRH persistence after influenza infection in C57BL/6 mice.

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A reverse method involves the pre-formation of an Matrimid (MI)-selective layer, followed by a porous polysulfone (PSF) support deposition. The membrane exhibited a high H/CH selectivity and a moderate H permeance. This study introduces a facile method to produce membranes with inexpensive materials.

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Article Synopsis
  • - This study investigates Petersen's hernia, which can occur after specific types of stomach surgeries, and compares two methods for preventing bowel obstruction caused by this hernia: the conventional defect closure method and the newer mesenteric fixation method.
  • - Conducted as a randomized controlled trial in Korea, the research includes patients with diagnosed gastric cancer who have undergone certain types of surgical anastomosis and aims to determine the effectiveness of each method in preventing bowel obstruction over a three-year period.
  • - Results from this trial are expected to provide valuable insights on the efficacy and safety of the mesenteric fixation method, potentially establishing it as a superior technique for closing Petersen's defects.
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Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently emerged as novel cardioprotective agents. However, their direct impact on cardiomyocyte injury is yet to be studied. In this work, we investigate the underlying molecular mechanisms of empagliflozin (EMPA), an SGLT2 inhibitor, in mitigating palmitate (PA)-induced cardiomyocyte injury in H9c2 cells.

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  • The long-term effects of COVID-19, known as Post-Acute Sequelae of COVID-19 (PASC), are becoming a major public health issue linked to poor recovery of organs and abnormal immune responses post-infection.
  • A mouse model was developed to study patients with respiratory PASC, revealing unique immune cell interactions that disrupt lung cell regeneration and contribute to lung fibrosis after initial infection.
  • Interventions targeting certain inflammatory signals were found to improve lung recovery, suggesting potential therapeutic strategies to address fibrosis that develops from respiratory viral infections.
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Urinomas are an accumulation of urine in the perirenal or paraureteral space due to urinary tract leakage. Stimulation of an inflammatory response results in the formation of a thick wall that encapsulates the urine. Etiologies of urinomas include trauma, surgery, or spontaneous occurrence.

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