Comput Med Imaging Graph
December 2024
Deep neural network (DNN) models have been applied to a wide variety of medical image analysis tasks, often with the successful performance outcomes that match those of medical doctors. However, given that even minor errors in a model can impact patients' life, it is critical that these models are continuously improved. Hence, active learning (AL) has garnered attention as an effective and sustainable strategy for enhancing DNN models for the medical domain.
View Article and Find Full Text PDFContext.—: Seegene Medical Foundation, one of the major clinical laboratories in South Korea, developed SeeDP, an artificial intelligence (AI)-based postanalytic daily quality control (QC) system that reassesses all gastrointestinal (GI) endoscopic biopsy (EB) slides for incorrect diagnoses.
Objective.
Stud Health Technol Inform
August 2024
Tumor Cellularity (TC) is an important metric for assessing organ tumor burden. However, manual cell counting is not feasible due to large volumes of pathology images and inconsistent measurements between pathologists. The PAIP 2023 Challenge aimed to solve this problem using AI.
View Article and Find Full Text PDFBackground: Convolutional neural network-based image processing research is actively being conducted for pathology image analysis. As a convolutional neural network model requires a large amount of image data for training, active learning (AL) has been developed to produce efficient learning with a small amount of training data. However, existing studies have not specifically considered the characteristics of pathological data collected from the workplace.
View Article and Find Full Text PDFBackground: Colorectal and gastric cancer are major causes of cancer-related deaths. In Korea, gastrointestinal (GI) endoscopic biopsy specimens account for a high percentage of histopathologic examinations. Lack of a sufficient pathologist workforce can cause an increase in human errors, threatening patient safety.
View Article and Find Full Text PDFAnn Surg Treat Res
August 2022
Purpose: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis and a lack of targeted therapy. Overexpression of is thought to be associated with this aggressive subtype of cancer. Here, we performed a comprehensive analysis and assessed the association between overexpression of and TNBC.
View Article and Find Full Text PDFCNN-based image processing has been actively applied to histopathological analysis to detect and classify cancerous tumors automatically. However, CNN-based classifiers generally predict a label with overconfidence, which becomes a serious problem in the medical domain. The objective of this study is to propose a new training method, called MixPatch, designed to improve a CNN-based classifier by specifically addressing the prediction uncertainty problem and examine its effectiveness in improving diagnosis performance in the context of histopathological image analysis.
View Article and Find Full Text PDFThis paper proposes a deep learning-based patch label denoising method (LossDiff) for improving the classification of whole-slide images of cancer using a convolutional neural network (CNN). Automated whole-slide image classification is often challenging, requiring a large amount of labeled data. Pathologists annotate the region of interest by marking malignant areas, which pose a high risk of introducing patch-based label noise by involving benign regions that are typically small in size within the malignant annotations, resulting in low classification accuracy with many Type-II errors.
View Article and Find Full Text PDFMolecular markers are helpful diagnostic tools, particularly for cytologically indeterminate thyroid nodules. Preoperative rearrangement analysis in and wild-type indeterminate thyroid nodules would permit the formulation of an unambiguous surgical plan. Cycle threshold values according to the cell count for detection of the rearrangement by real-time reverse transcription-polymerase chain reaction (RT-PCR) using fresh and routine air-dried TPC1 cells were evaluated.
View Article and Find Full Text PDFLow-grade cribriform cystadenocarcinoma (LGCCC) of the salivary gland is a rare tumor. We report the cytologic features and histologic correlation of a patient with LGCCC. A 57-year-old man had a hardly palpable, nontender mass in the right cheek area followed over nine months.
View Article and Find Full Text PDFMultifocal papillary thyroid carcinoma (mPTC) comprises about 20-30% of PTC. In mPTC, individual tumor foci can be identical or frequently composed of different histological types including follicular, solid, tall-cell or conventional patterns. We report a case of mPTC consisting of one encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) and three conventional PTCs in a 44-year-old woman.
View Article and Find Full Text PDFPrimary squamous cell carcinoma of the thyroid (SCC-T) is extremely rare. Its clinical presentation is similar to that of anaplastic carcinoma. Metastasis or extension from the head and neck area should be ruled out, as patients with SCC-T have a poorer prognosis than patients who have a thyroid extension from an adjacent tumor.
View Article and Find Full Text PDFTherapy-related acute leukemia showing mixed phenotype is extremely rare. We report a 49-year-old woman who presented with palpable masses in her neck and back. She had received systemic chemotherapy (adriamycin and cisplatin) and radiotherapy for endometrial adenocarcinoma 7 years before.
View Article and Find Full Text PDFOccipital neuralgia is a form of headache that involves the posterior occiput in the greater or lesser occipital nerve distribution. Pain can be severe and persistent with conservative treatment. We present a case of intractable occipital neuralgia that conventional therapeutic modalities failed to ameliorate.
View Article and Find Full Text PDF