Publications by authors named "Young Sig Gil"
The continued spread of drug-resistant tuberculosis is one of the most pressing and complex challenges facing tuberculosis management worldwide. Therefore, developing a new class of drugs is necessary and urgently needed to cope with the increasing threat of drug-resistant tuberculosis. This study aims to discover a potential new class of tuberculosis drug candidates different from existing tuberculosis drugs.
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- * Toxicity studies on DFC-2 involved assessing both single and long-term doses in rats, revealing that a 2000 mg/kg dose didn't cause fatalities or organ damage, and a 300 mg/kg/day dose over 28 days showed no adverse effects.
- * DFC-2 also tested negative for genetic toxicity in multiple assays, suggesting it has a strong potential as a safe and effective anti-tubercular drug.
To develop an effective oral drug delivery system with accelerated absorption in human subjects for a poorly water-soluble acelofenac, five aceclofenac-loaded soft capsule preparations containing various ratios of different solubilizers were prepared and their dissolution tests were carried out. Among five preparations tested, a preparation with ethanolamine was selected as a formula of aceclofenac soft capsule (Korea United Pharm. Co.
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