Publications by authors named "Young S Choi"

Objective: The objective of this research was to identify the metabolite compounds and health-promoting properties of goat meat fermented sausages containing different amounts of fig and pineapple powder (0.1%, 0.25%, and 0.

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  • Plastics are increasingly prevalent in our lives, breaking down into microplastics (MPs) that spread in the environment, exposing all living organisms to their effects.* -
  • Extracellular vesicles (EVs) are tiny particles released by cells that aid in communication and can transport proteins and other materials between cells.* -
  • This study found that polystyrene microplastics can be transferred between cells through EVs, suggesting they may contribute to adverse health effects, and highlights the need for further research in this area.*
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Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor, and the presence of glioma stem cells (GSCs) has been linked to its resistance to treatments and recurrence. Additionally, aberrant glycosylation has been implicated in the aggressiveness of cancers. However, the influence and underlying mechanism of N-glycosylation on the GSC phenotype and GBM malignancy remain elusive.

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  • Nasal irrigation is important after endoscopic sinus surgery (ESS) for those with chronic rhinosinusitis (CRS), and a study evaluated the use of N-acetylcysteine (NAC) vs. saline for this purpose.
  • In a trial with 49 patients, those using NAC showed better outcomes in terms of postnasal drip, smell dysfunction, and crust issues two weeks post-surgery, although these results were not statistically significant over time.
  • Overall, NAC was well tolerated with no reported side effects and indicated some benefits compared to saline irrigation in the immediate recovery phase after ESS for CRS without nasal polyps.*
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  • - The study compared uterine volume (UV) among Turner syndrome (TS) patients who underwent pubertal induction (PI), those who experienced natural menarche (NM), and a control group without TS to identify key factors in uterine development.
  • - Results indicated that the first UV was significantly larger in the NM group compared to the PI group, with the final UV of the PI group still being smaller than the NM group despite an increase over time.
  • - The findings suggest that while natural menarche leads to normal uterine development, those with TS who received pubertal induction may have smaller, less developed uteruses, possibly due to late initiation of hormone replacement therapy (HRT) and the type of estrogen used.
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  • Accurate and timely diagnosis of Alzheimer's disease (AD) is essential for effective treatment, with biomarkers emerging as a minimally invasive diagnostic tool.
  • The study developed an electrochemical immunosensor (EI) using enzyme immunoassay to quantify four specific AD biomarkers on screen-printed gold electrodes, achieving low limits of detection (LOD).
  • The successful quantification of these biomarkers in buffer and human serum samples indicates the potential for these immunosensors to be used for AD detection and possibly other related diseases in the future.
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This study aimed to evaluate the adverse effects of particulate matter (PM) exposure on endometrial cells and fertility and to identify possible underlying mechanisms. Thirteen women (aged 15-52 years) were included in this study. Enrolled patients underwent laparoscopic surgery at Gangnam Severance Hospital between 1 January and 31 December 2021.

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Background: Turner syndrome (TS) is a common chromosomal abnormality, which is caused by loss of all or part of one X chromosome. Hormone replacement therapy in TS is important in terms of puberty, growth and prevention of osteoporosis however, such a study has never been conducted in Korea. Therefore, the purpose of our study was to determine relationship between the starting age, duration of estrogen replacement therapy (ERT) in TS and develop a hormone replacement protocol suitable for the situation in Korea.

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The large carrier lifetime mobility product and strong stopping power for high-energy X-rays make halide perovskites an attractive candidate for next-generation X-ray detectors. In particular, high-energy X-rays in the range of several tens of keV require halide perovskite absorber layers with thicknesses exceeding a few millimeters. To avoid carrier scattering caused by grain boundaries at such thicknesses, the utilization of single crystals is desirable.

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Background: Currently, there are differences in both demographics and indications for bariatric surgery between Eastern and Western countries. We compared postoperative outcomes between Korean and American bariatric programs in order to assess how bariatric surgery differently affects these populations.

Methods: We enrolled 540 patients who underwent bariatric surgery at University of California, Los Angeles (UCLA) and 85 patients who underwent surgery at Kosin University Gospel Hospital (KUGH) between January 2019 and December 2020.

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Objective: We aimed to determine whether ovarian-preserving surgery for adnexal torsion helps preserve ovarian function without increasing the risk of postoperative complications.

Methods: We retrospectively evaluated 71 women who were surgically diagnosed with adnexal torsion between January 2015 and December 2019 at Severance Hospital, Yonsei University College of Medicine (ovarian preservation group, 56; oophorectomy, 15). Serum anti-Müllerian hormone (AMH) levels measured within 6 months before surgery were compared to levels measured 6-24 months after surgery.

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  • The study investigates endometrial transcriptomic changes during the early and mid-secretory phases of the menstrual cycle in women undergoing IVF-ET.
  • Thirty patients were categorized based on whether they became pregnant or not after the IVF-ET, with their endometrial tissue analyzed for differentially expressed genes (DEGs).
  • Results indicate distinct DEGs between pregnant and non-pregnant groups, suggesting that the endometrium's molecular profile plays a crucial role in the success of IVF-ET outcomes.
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Background: A protocol for using human endometrium derived induced pluripotent stem cells (iPSCs) to derive hematopoietic and erythroid lineages will be elaborated, through a two-phase culture system.

Methods: Discarded endometrial tissues were obtained from women receiving hysterectomy in their 4th to 5th decade due to benign uterine conditions. pCE-Sox2, Oct4, Klf4, L-Myc and Lin28 episomal vectors were used to electrotransfect the endometrial stromal cells.

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Objectives: Formononetin is one of the phytoestrogens that functions like a selective estrogen receptor modulator (SERM). In this study, we evaluated the effects of formononetin on endometriosis progression in vitro and in vivo.

Materials And Methods: After pathological confirmation, 10 eutopic and ectopic endometria were collected from patients with endometriosis.

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Diesel exhaust particles (DEPs) are a major component of air pollution and adversely affect respiratory and cardiovascular disease and diabetic foot ulcers if diabetic patients are exposed to them. There are currently no studies on treating diabetic wounds exposed to DEPs. So, the effect of a combination of probiotics and Korean red ginseng on a diabetic wound model exposed to DEPs was confirmed.

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Purpose: The neutrophil-to-lymphocyte ratio (NLR) is an extensively analyzed prognostic inflammatory index in cardiac patients. The degree of change in NLR values before and after surgery (delta-NLR) can represent the inflammatory response induced by surgery and serve as a meaningful prognostic biomarker in surgical patients; however, this has not been well investigated. We aimed to investigate the predictive value of the perioperative NLR and delta-NLR for outcomes of off-pump coronary artery bypass (OPCAB) surgery by evaluating "days alive and out of hospital (DAOH)", a novel patient-centered outcome.

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The purpose of this study was to assess the cytotoxicity and antibacterial effects of AgNP-impregnated Tetracalcium phosphate-dicalcium phosphate dihydrate (TTCP-DCPD). Using in vitro experiments, the cytotoxicity of AgNP-impregnated TTCP-DCPD against fibroblasts and osteocytes was assessed in terms of cell viability by water-soluble tetrazolium salt assay. To assess antibacterial effects, a disc diffusion test was used; osteomyelitis was induced first in vivo, by injection of methicillin-resistant into the tibia of rats.

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Lumbar spinal stenosis is a common spinal degenerative condition. Minimally invasive interlaminar full-endoscopic decompressive laminectomy provides greater patient satisfaction and faster recovery than open decompressive laminectomy. The aim of our randomized controlled trial will be to compare the safety and efficacy of interlaminar full-endoscopic laminectomy and open decompressive laminectomy.

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Background: Single nucleotide polymorphisms (SNPs) are reportedly associated with repeated abortion. Thus, genetic analysis based on race is the key to developing accurate diagnostic tests. This study analyzed the genetic polymorphisms of recurrent pregnancy loss (RPL) patients among Korean women compared to the controls.

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