CD73 Overexpression Promotes Progression and Recurrence of Papillary Thyroid Carcinoma.

CD73 is involved in tumor immune escape and promotes the growth and progression of cancer cells. The functional role of CD73 expression in papillary thyroid carcinoma (PTC) has not yet been established. In 511 patients with PTC, immunohistochemistry for CD73 on tissue microarrays showed that the high expression of CD73 was associated with an aggressive histologic variant ( = 0.

Risk Stratification Using a Novel Genetic Classifier Including Promoter Mutations for Differentiated Thyroid Cancer with Distant Metastasis.

Although most differentiated thyroid carcinomas (DTCs) have indolent behavior, DTCs with distant metastasis have a poor prognosis. However, there are no validated markers that predict the risk of distant metastasis and the prognosis of DTC. We aimed to develop a genetic classifier for predicting the outcomes of DTC patients with distant metastases.

Comprehensive DNA Methylation Profiling Identifies Novel Diagnostic Biomarkers for Thyroid Cancer.

There are no reliable biomarkers to accurately differentiate indolent thyroid tumors from more aggressive thyroid cancers. This study aimed to develop new DNA methylation markers for diagnosis and recurrence risk stratification of papillary thyroid carcinoma (PTC). Thyroid tumor-specific DNA methylation profiling was investigated in 34 fresh frozen tissues, which included nontumor ( = 7), noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP,  = 6) and PTC ( = 21), using the Illumina HumanMethylation EPIC array.

CCND1 Splice Variant as A Novel Diagnostic and Predictive Biomarker for Thyroid Cancer.

Cyclin D1 protein is aberrantly overexpressed in thyroid cancers, but mutations of the gene are rare in these tumors. We investigated the rs9344 (G870A) polymorphism and the expression profiles of wild-type and shortened oncogenic isoform at the mRNA and protein levels in 286 thyroid tumors. Genotype AA of rs9344 was associated with high expression of mRNA and was more frequently found in thyroid cancer than in benign tumors.