The management and prognosis of patients with hepatocellular carcinoma: what has changed in 20 years?

Background & Aims: There has been remarkable progress in the management of hepatocellular carcinoma (HCC) during the last several decades, but its effect on the prognosis of HCC patient needs clarification. We analysed the changes that affected prognosis of HCC patients diagnosed over two different eras.

Methods: A retrospective study of 1318 patients diagnosed with HCC from 1986 to 2012 was conducted.