Publications by authors named "Young Joon Hong"
Background And Objectives: Heart failure is a potentially fatal event caused by diverse cardiovascular diseases, leading to high morbidity and mortality. Histone deacetylase (HDAC) inhibitors positively influence cardiac hypertrophy, fibrosis, hypertension, myocardial infarction, and heart failure, causing some side effects. We aimed to investigate the effect of the novel HDAC inhibitor YAK577 on the heart failure mouse model and its underlying mechanism.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the link between myocardial bridging (MB) and coronary vasospasm (CVS), aiming to see if CVS worsens outcomes for patients with MB over the long term.
- - Researchers included 254 patients with MB, dividing them into two groups: those with CVS (168 patients) and those without (86 patients), and examined major adverse cardiovascular events (MACEs) over an average follow-up of 8.15 years.
- - Results showed that patients with CVS experienced significantly higher rates of MACEs (35.1%) compared to those without CVS (26.7%), indicating that CVS negatively impacts the clinical outcomes of MB patients, suggesting a need for further research.
Background: Despite increasing evidence on the benefits of statin therapy for acute myocardial infarction (AMI), differential outcomes in accordance with statin intensity have not been evaluated in patients with AMI and low-density lipoprotein cholesterol (LDL-C) levels < 55 mg/dL. Therefore, this study aimed to compare the clinical outcomes of high- and moderate-intensity statin therapy in this population.
Methods: A total of 752 participants with AMI and LDL-C levels < 55 mg/dL from a Korean nationwide multicenter observational cohort (2016-2020) were included and categorized into two groups: high-intensity statin group (n = 384) and moderate-intensity statin group (n = 368).
Article Synopsis
- The study examined the excited-state dynamics of a hybrid system made up of a conjugated polymer (P3HT), gold nanoparticles, and quantum dots.
- Using transient absorption spectroscopy, it was found that polaron pairs in this ternary system have shorter electron-hole separation distances due to the influence of nanocrystals, leading to more back-recombination into singlet excitons.
- As a result, the photoluminescence intensity of the polymer increased in the hybrid system, offering valuable insights for the development of high-efficiency optoelectronic devices.
Article Synopsis
- * Results showed that during the first week, STEMI patients had a significantly higher mortality rate (4.62%) compared to NSTEMI patients (1.79%), but this trend reversed after the second week for men and the tenth week for women.
- * The research highlights the need for further studies to develop advanced risk prediction models based on time-point mortality outcomes, as different baseline variables influenced mortality rates over time.
Experimental validation of coronary stenosis severity and development of ischemic myocardium.
Rev Esp Cardiol (Engl Ed)
October 2024
Introduction And Objectives: The current study aimed to evaluate the causal association between hemodynamically significant stenosis and the occurrence of ischemic myocardium using an experimental animal model of coronary artery stenosis.
Methods: In Yorkshire swine (n = 10), coronary stenosis in the left anterior descending artery was induced using a customized vascular occluder to create varying degrees of occlusion severity (40%-99%). Serial changes in coronary pressure and flow velocity were measured in the left anterior descending artery before and after the implantation of the vascular occluder.
Many countries have published clinical practice guidelines for appropriate clinical decisions, optimal treatment, and improved clinical outcomes in patients with acute coronary syndrome. Developing guidelines that are specifically tailored to the Korean environment is crucial, considering the treatment system, available medications and medical devices, racial differences, and level of language communication. In 2017, the Korean Society of Myocardial Infarction established a guideline development committee.
View Article and Find Full Text PDFBackground And Objectives: Cigarette smoking is a major risk factor for atherosclerosis. Nicotine, a crucial constituent of tobacco, contributes to atherosclerosis development and progression. However, evidence of the association between nicotine and neointima formation is limited.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the effects of clopidogrel and ticagrelor on bleeding and ischemia risks in elderly East Asian patients with diabetes and acute myocardial infarction who underwent percutaneous coronary intervention.
- It analyzed data from 838 patients over 75 years old, ultimately comparing 466 patients after matching for treatment type.
- Findings suggested that there was no significant difference in the incidence of severe bleeding or ischemia between those treated with ticagrelor versus clopidogrel, indicating the need for larger trials to find the best antiplatelet therapy for this group.
Article Synopsis
- * Using this imaging technology, doctors can perform better heart surgeries called PCI, especially for complicated cases and high-risk patients.
- * The paper reviews the latest research and guidelines on how to use this imaging to improve heart stent placement and overall patient care.
Article Synopsis
- Dyslipidemia, a key risk factor for heart attacks, has shown an increase in prevalence among Korean patients from 11.1% to 17.1% between 2011 and 2020 as this study explored trends in its management.
- Over the same period, there was a rise in statin prescriptions from 92.9% to 97.0%, with high-intensity statin use increasing dramatically and greater adoption of drugs like ezetimibe.
- Despite improvements in managing dyslipidemia, with more patients achieving lipid targets, ongoing efforts are crucial to further lower the risk of heart-related complications.*
Background: The prognostic implication of mildly reduced ejection fraction (mrEF) after acute myocardial infarction has not been clearly demonstrated. We investigated the long-term risk of cardiovascular death and its predictors in patients with mrEF following acute myocardial infarction.
Methods And Results: A total of 18 668 patients who presented with acute myocardial infarction were included in 2 prospective, multicenter registries.
Optical coherence tomography-guided versus angiography-guided percutaneous coronary intervention for patients with complex lesions (OCCUPI): an investigator-initiated, multicentre, randomised, open-label, superiority trial in South Korea.
Lancet
September 2024
Article Synopsis
- The OCCUPI trial aimed to determine if optical coherence tomography (OCT) guidance during percutaneous coronary intervention (PCI) provides better clinical outcomes compared to traditional angiography guidance for complex heart lesions over a year.
- Conducted across 20 hospitals in South Korea, the trial included 1,604 patients aged 19-85 and utilized randomization to assign participants to either OCT or angiography guidance during their PCI procedure.
- The main outcome measured was the rate of major adverse cardiac events, but the effectiveness of OCT guidance in reducing these events compared to angiography guidance remains uncertain, as the study was designed to assess potential clinical benefits.
Optimal timing of revascularization for patients who presented with non-ST segment elevation myocardial infarction (NSTEMI) and severe left ventricular (LV) dysfunction is unclear. A total of 386 NSTEMI patients with severe LV dysfunction from the nationwide, multicenter, and prospective Korea Acute Myocardial Infarction Registry V (KAMIR-V) were enrolled. Severe LV dysfunction was defined as LV ejection fraction ≤ 35%.
View Article and Find Full Text PDF: Self-recognition of recurrent myocardial infarction (re-MI) may be essential for reducing prehospital time contrast to awareness of re-MI symptoms. However, data on the current status and clinical impact of self-recognition of re-MI are limited in the contemporary period. Thus, this study aimed to increase this body of knowledge.
View Article and Find Full Text PDFArticle Synopsis
- * Twenty patients were enrolled, and results after 8 months showed minimal in-stent late lumen loss (0.7 mm) and complete stent strut coverage, indicating successful healing.
- * There were no adverse cardiovascular events reported within the same period, suggesting that the new stent design is safe and effective in treating coronary artery disease.
Background And Objectives: Familial hypercholesterolemia (FH) increases the risk of premature cardiovascular disease through disrupted low-density lipoprotein cholesterol (LDL-C) metabolism. Although FH is a severe condition, it remains widely underdiagnosed, which can be attributed to barriers in genetic testing and a lack of awareness. This study aims to propose and evaluate a targeted screening program for FH in South Korea by integrating the General Health Screening Program (GHSP) with cascade genetic screening.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied 861 patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) to understand how the timing of hospitalization affects mortality rates over two years.
- * They found that patients who presented late (after 12 or 24 hours) had a significantly higher risk of death compared to those who arrived early, with adjusted hazard ratios confirming this increased risk.
- * Factors such as being female, not using emergency services, and having high creatinine levels were linked to late presentation, indicating a need for better systems to minimize delays in seeking treatment.
Micro-light-emitting diodes (μLEDs) have gained significant interest as an activation source for gas sensors owing to their advantages, including room temperature operation and low power consumption. However, despite these benefits, challenges still exist such as a limited range of detectable gases and slow response. In this study, we present a blue μLED-integrated light-activated gas sensor array based on SnO nanoparticles (NPs) that exhibit excellent sensitivity, tunable selectivity, and rapid detection with micro-watt level power consumption.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to compare the efficacy of drug-coated balloon (DCB) PCI versus drug-eluting stent (DES)-only PCI in patients with complex coronary artery lesions.
- - A total of 126 patients received DCB-based PCI, which was compared with 234 patients who underwent DES-only PCI, focusing on the rate of target vessel failure (TVF) over 2 years.
- - Results showed that DCB-based PCI had similar risks for TVF and other complications compared to DES-only PCI, suggesting that DCB could be a viable alternative in complex cases.
Micro light-emitting diodes (micro-LEDs) are pivotal in next-generation display technologies, driven by the need for high pixel density. This study introduces a novel methodology utilizing wide sapphire nanomembranes (W-SNM) as a dual-purpose template for high-quality epitaxial growth and the mechanical lift-off of individual micro-LEDs. Micro-LEDs grow individually on W-SNM, obviating the chip singulation process.
View Article and Find Full Text PDFBackground: A drug-eluting stent (DES) is a highly beneficial medical device used to widen or unblock narrowed blood vessels. However, the drugs released by the implantation of DES may hinder the re-endothelialization process, increasing the risk of late thrombosis. We have developed a tacrolimus-eluting stent (TES) that as acts as a potent antiproliferative and immunosuppressive agent, enhancing endothelial regeneration.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to improve the prediction of which coronary artery lesions could lead to acute coronary syndrome (ACS) by integrating artificial intelligence (AI) with traditional methods.
- The research focused on patients who had undergone coronary CT angiography (CTA) before experiencing an ACS event, analyzing both culprit (problematic) and nonculprit lesions.
- The new model incorporating AI features showed significantly better predictability for identifying high-risk lesions compared to standard methods, suggesting that AI can enhance cardiac risk assessment.
Objectives: This study investigated the optimal timing for percutaneous coronary intervention (PCI) in patients with NSTEMI complicated by heart failure (HF).
Methods: In total, 762 patients with NSTEMI and HF in a multicenter, prospective registry in South Korea were classified according to the Killip classification (Killip class 2, n = 414 and Killip class 3, n = 348) and underwent early (within 24 h) and delayed (after 24 h) PCI. The primary outcome was all-cause mortality which was further analyzed with landmark analysis with two months as a cut-off.