Publications by authors named "Young Ho Park"

Aims: This study evaluated the effects of choline alfoscerate on cognitive function and quality of life in T2DM patients with mild cognitive decrements.

Materials And Methods: In a double-blind, randomized, placebo-controlled trial, we recruited 36 individuals with T2DM and mild cognitive impairment which was assessed by the Mini-Mental State Examination (MMSE) score of 25-28, and randomly assigned them to receive either 1200 mg/day of choline alfoscerate or a placebo. Four additional questionnaires-the 36-Item Short Form Survey, the modified Informant Questionnaire on Cognitive Decline in the Elderly, the Korean version of Activities of Daily Living, and the Patient Health Questionnaire-were investigated at 6 and 12 months and analysed via mixed-effects models for repeated measures.

View Article and Find Full Text PDF
Article Synopsis
  • Surface plasmon polaritons (SPPs) are important in sensitive biomolecular detection and optical communication technologies, but their interaction with other near-field modes like quasi-cylindrical waves (QCWs) and composite diffracted evanescent waves (CDEWs) is not fully understood.
  • This study utilized a nano groove structure and a stable femtosecond laser to measure the spatial phase distribution around the edge of a nano slit, achieving a high precision measurement of refractive index changes.
  • The findings provide insights into the near-field effects on electron concentration at the nano structures, enhancing the understanding of SPP phenomena which could improve the design and application of nano-plasmonic technologies.
View Article and Find Full Text PDF
Article Synopsis
  • The study addresses the lack of ethnic diversity in Alzheimer's research, focusing on Asian populations, particularly Koreans, to enhance understanding of the disease.
  • RNA sequencing was conducted on blood samples to analyze gene expression and its relation to amyloid beta (Aβ) deposition, leading to the identification of 265 dysregulated genes associated with Aβ.
  • Findings suggest that certain genes linked to Aβ deposition are enriched in natural killer cell-mediated immunity, highlighting potential new avenues for diagnostics and therapies in Alzheimer's disease.
View Article and Find Full Text PDF

Lecanemab (product name Leqembi®) is an anti-amyloid monoclonal antibody treatment approved for use in Korea for patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's disease. The Korean Dementia Association has created recommendations for the appropriate use of lecanemab to assist clinicians. These recommendations include selecting patients for administration, necessary pre-administration tests and preparations, administration methods, monitoring for amyloid related imaging abnormalities (ARIA), and communication with patients and caregivers.

View Article and Find Full Text PDF

Background: Cholinesterase inhibitors (ChEIs) are prescribed for Alzheimer's disease (AD) and sometimes for mild cognitive impairment (MCI) without knowing underlying pathologies and its effect on cognition. We investigated the frequency of ChEI prescriptions in amyloid-negative MCI and their association with cognitive changes in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.

Methods: We included participants with amyloid positron emission tomography (PET)-negative MCI from the ADNI.

View Article and Find Full Text PDF

Background: Subjective cognitive decline (SCD) refers to self-reported cognitive decline in individuals with normal performance on standardized cognitive tests. Understanding the factors predicting progression from SCD to mild cognitive impairment (MCI) is crucial, as approximately 14% of SCD cases progress to dementia and about 27% develop MCI over four years.

Objective: This study aims to identify neuropsychological predictors of progression from SCD to MCI, focusing on cognitive domains assessed through neuropsychological tests.

View Article and Find Full Text PDF
Article Synopsis
  • Scientists found a protein called NPTX2 that can help identify Alzheimer's disease.
  • *They studied tiny molecules called miRNAs and discovered that one called miR-133b is linked to Alzheimer's and brain health.
  • *The research shows that miR-133b might help the NPTX2 protein work better, which could be important for understanding Alzheimer's.
View Article and Find Full Text PDF

Additive manufacturing (AM) is not necessarily a new process but an advanced method for manufacturing complex three-dimensional (3D) parts. Among the several advantages of AM are the affordable cost, capability of building objects with complex structures for small-batch production, and raw material versatility. There are several sub-categories of AM, among which is fused filament fabrication (FFF), also commonly known as fused deposition modeling (FDM).

View Article and Find Full Text PDF

Background: Targeting the tumor microenvironment represents an emerging therapeutic strategy for cancer. Macrophages are an essential part of the tumor microenvironment. Macrophage polarization is modulated by mitochondrial metabolism, including oxidative phosphorylation (OXPHOS), the tricarboxylic acid (TCA) cycle, and reactive oxygen species content.

View Article and Find Full Text PDF

As the potential adverse health and environmental effects of nanoscale pollutants have garnered significant attention, the demand for monitoring and capturing ultrafine particulate matter has been growing. With the rise in ultrafine dust emissions, this issue has become increasingly important. However, submicron particles require advanced strategies to be captured because of their limited inertial effect.

View Article and Find Full Text PDF

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder influenced by various factors, including liver function, which may impact the clearance of amyloid-β (Aβ) in the brain. This study aimed to explore how the apolipoprotein E () ε4 allele affects the relationship of liver function markers with AD pathology and cognition.

Methods: We analyzed data from two independent cohorts, including 732 participants from the Hallym University Medical Center and 483 from the Alzheimer's Disease Neuroimaging Initiative, each group consisting of individuals with and without the ε4 allele.

View Article and Find Full Text PDF

Alzheimer's disease (AD) is the most common neurodegenerative disorder, and amyloid beta oligomers (AβO), which are pathological markers of AD, are known to be highly toxic. AβO increase mitochondrial dysfunction, which is accompanied by a decrease in mitochondrial fusion. Although mitofusin (Mfn) 1 and Mfn2 are mitochondrial fusion proteins, Mfn2 is known to regulate endoplasmic reticulum (ER) function, as it is located in the ER.

View Article and Find Full Text PDF
Article Synopsis
  • Lung cancer treatment struggles with frequent recurrence and metastasis due to cancer stem cells (CSCs), making it important to identify specific CSC targets for targeted therapies.
  • The study shows that TIPRL, when upregulated in lung CSCs, activates the CaMKK2 signaling pathway to maintain stem cell characteristics and survival, influencing genes linked to cancer progression.
  • Targeting TIPRL and the CaMKK2 signaling axis could help combat drug resistance and lower metastatic spread in lung cancer, suggesting potential new therapeutic approaches.
View Article and Find Full Text PDF

Background And Purpose: This study aimed to evaluate the brain magnetic resonance imaging (MRI) of patients with acute transient global amnesia (TGA) using volumetric analysis to verify whether the brains of TGA patients have pre-existing structural abnormalities.

Methods: We evaluated the brain MRI data from 87 TGA patients and 20 age- and sex-matched control subjects. We included brain MRIs obtained from TGA patients within 72 hours of symptom onset to verify the pre-existence of structural change.

View Article and Find Full Text PDF

This study presents a comprehensive approach for simulating the additive manufacturing process of semi-crystalline composite polymers using Fused Deposition Modeling (FDM). By combining thermomechanical Finite Element Analysis (FEA) with experimental validation, our main objective is to comprehend and model the complex behaviors of 50 wt.% carbon fiber-reinforced Polyphenylene Sulfide (CF PPS) during FDM printing.

View Article and Find Full Text PDF

Additive manufacturing (AM) also commonly known as 3D printing is an advanced technique for manufacturing complex three-dimensional (3D) parts by depositing raw material layer by layer. Various sub-categories of additive manufacturing exist including directed energy deposition (DED), powder bed fusion (PBF), and fused deposition modeling (FDM). FDM has gained widespread adoption as a popular method for manufacturing 3D parts, even for heavy-duty industrial applications.

View Article and Find Full Text PDF

Human blood vessel organoids (hBVOs) offer a promising platform for investigating vascular diseases and identifying therapeutic targets. In this study, we focused on in vitro modeling and therapeutic target finding of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of hereditary stroke disorder caused by mutations in the NOTCH3 gene. Despite the identification of these mutations, the underlying pathological mechanism is elusive, and effective therapeutic approaches are lacking.

View Article and Find Full Text PDF

Introduction: Alzheimer's disease (AD) involves the complement cascade, with complement component 3 (C3) playing a key role. However, the relationship between C3 and amyloid beta (Aβ) in blood is limited.

Methods: Plasma C3 and Aβ oligomerization tendency (AβOt) were measured in 35 AD patients and 62 healthy controls.

View Article and Find Full Text PDF

Background And Purpose: Dementia subtypes, including Alzheimer's dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of F-Fluorodeoxyglucose Positron Emission Tomography (F-FDG PET) in differentiating these subtypes for precise treatment and management.

Methods: A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of F-FDG PET in dementia.

View Article and Find Full Text PDF

Various plasma biomarkers for amyloid-β (Aβ) have shown high predictability of amyloid PET positivity. However, the characteristics of discordance between amyloid PET and plasma Aβ42/40 positivity are poorly understood. Thorough interpretation of discordant cases is vital as Aβ plasma biomarker is imminent to integrate into clinical guidelines.

View Article and Find Full Text PDF

Background: Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) plaque accumulation and neurofibrillary tangles in the brain. Emerging evidence has suggested potential interactions between the brain and periphery, particularly the liver, in regulating Aβ homeostasis.

Objective: This study aimed to investigate the association of serum liver enzymes with brain amyloidopathy and cognitive performance in patients with complaints of cognitive decline.

View Article and Find Full Text PDF