Publications by authors named "Young H Ko"

Extracellular accumulation of amyloid-β (Aβ) peptides in the brain plays a significant role in the development of Alzheimer's disease (AD). While the co-localization and interaction of proteins and metal ions with Aβ in extracellular milieu are established, their precise pathological associations remain unclear. Here we report the impact of Zn(ii) on the anti-amyloidogenic properties of monomeric transthyretin (M-TTR), which coexists spatially with Aβ and Zn(ii) in extracellular fluids.

View Article and Find Full Text PDF

Background: In patients with metastatic renal cell carcinoma (mRCC), sites of metastatic involvement have been reported to be associated with a difference in survival. However, the frequency and survival according to different sites of metastases in Korean patients with mRCC remain unclear. Therefore, this study aimed to assess the frequency of metastatic site involvement and the association between sites of metastatic involvement and survival in Korean patients with mRCC.

View Article and Find Full Text PDF

Antimicrobial peptides (AMPs) are a current solution to combat antibiotic resistance, but they have limitations, including their expensive production process and the induction of cytotoxic effects. We have developed novel AMP candidate (peptide 3.1) based on indolicidin, among the shortest naturally occurring AMP.

View Article and Find Full Text PDF

Purpose: To investigate the form and level of daily caffeine intake recommended above 400 mg in medical students expected to consume caffeinated beverages to enhance their performance.

Methods: From May to June 2023, freshman through senior medical students at a medical school in Korea were administered a seven-item questionnaire designed to measure the amount of caffeine-containing foods consumed, the weekly interval between consumption, the reason for consumption, and the level of caffeine-induced symptoms experienced.

Results: Out of 443 students, 361 responded (81.

View Article and Find Full Text PDF

While covalent organic frameworks (COFs) have been extensively investigated in the field of organic electrolyte materials, there is potential for further enhancement of their room-temperature ionic conductivity. This study introduces a novel methodology to induce self-exfoliation in the parent COF during synthesis through a postmodification technique. This process yields covalent organic nanosheets that feature pyridinium sulfobetaine groups, referred to as PS-CON.

View Article and Find Full Text PDF

Background: Ewing's sarcoma (ES) is a neuroectodermal tumor that typically occurs in the bones and soft tissues of children and young adults. Primary renal ES is rare; only a few cases and a small case series have been documented, and only four cases involved primary renal ES in older people (> 65 years old).

Case Summary: Herein, we describe the radiological and pathological features of primary renal ES in an older person.

View Article and Find Full Text PDF

We aim to investigate the peri-operative outcomes after extraperitoneal single-port based robot-assisted radical prostatectomy (eSP-RARP) utilizing the da Vinci SP system compared to conventional transperitoneal multi-port counterparts (tMP-RARP), in an era when pelvic lymph node dissection (PNLD) was omitted for the node-negative case. With exclusion criteria of volume  + 50 g, suspicious rectal invasion, and node-positive disease given relatively weak grasping power and limited range of motion from the current SP system, 50 consecutive patients (Since December 2021) with localized prostate cancer underwent eSP-RARP by a single urologist maintaining identical surgical technique for 100 consecutive tMP-RARP cases (Since December 2020). Given initial selection criteria, each group was matched to a 1:1 ratio based on the risk-stratification parameters and the prostate volume.

View Article and Find Full Text PDF
Article Synopsis
  • This study compared the effectiveness of intravesical gemcitabine and BCG therapy for treating intermediate- or high-risk non-muscle invasive bladder cancer (NMIBC).
  • Data from 149 patients was analyzed, revealing no significant differences in complete remission rates, progression-free survival, or adverse event rates between the two treatments within the first year.
  • Gemcitabine showed comparable short-term efficacy to BCG, but the researchers noted that further long-term studies are needed to fully assess the treatments' effectiveness.
View Article and Find Full Text PDF

Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy. In the present study, we aimed to elucidate the role of glucose metabolism in the acquired resistance of AML cells to cytarabine (Ara-C) and to explore it as a therapeutic target.

View Article and Find Full Text PDF
Article Synopsis
  • - This study analyzed the carbonate system and air-sea CO exchange in the western inshore waters of South Korea in 2020, highlighting the importance of these areas for accurate estimates of CO fluxes in the southeastern Yellow Sea.
  • - Seasonal changes in seawater CO partial pressure (pCO) were primarily influenced by thermal effects, while in the summer, inshore waters showed significant variability in pCO levels, fluctuating between 185 and 1000 μatm.
  • - Unlike offshore regions, inshore waters less than 20 m deep emitted about 100 Gg C per year into the atmosphere, indicating a need for more detailed observations to improve understanding of air-sea CO exchange dynamics.
View Article and Find Full Text PDF
Article Synopsis
  • Pancreatic cancer has a very low five-year survival rate (10%) primarily due to late diagnoses and restricted treatment options, with current frontline therapies showing limited effectiveness against cancer stem cells (CSCs).
  • The study investigated the effects of various treatments (radiation, 5-FU, and 3-Bromopyruvate) on pancreatic tumor organoids, revealing that while radiation increased CSC markers (OCT4 and SOX2), 5-FU decreased them, and that a combination of 5-FU and radiation inhibited CSC self-renewal.
  • Findings suggest that the expression levels of CSC markers and the β-catenin pathway could be potential targets for improving treatment efficacy against pancreatic cancer.
View Article and Find Full Text PDF

The World Health Organization/International Society of Urological Pathology (WHO/ISUP) grading of renal cell carcinoma (RCC) is classified from grade 1-4, regardless of subtype. The National Comprehensive Cancer Network (NCCN) guidelines (2022) state that if there is an adverse pathological feature, such as grade 3 or higher RCC in stage 1 patients, more rigorous follow-up imaging is recommended. However, the RCC guidelines do not provide specific treatment or follow-up policies by tumor grade.

View Article and Find Full Text PDF
Article Synopsis
  • The Arctic is experiencing significant impacts from climate change and pollution, particularly from increased wildfires between 2019 and 2021.
  • The study found a
  • 213% rise in chlorophyll-a levels
  • , linked to nitrogen deposition from wildfire plumes, indicating enhanced biological activity.
  • Additionally, the sea ice melted approximately
  • 10 days faster
  • than normal, suggesting that the effects of black carbon could extend the growing season for phytoplankton in the East Siberian Sea.
View Article and Find Full Text PDF

The current incidence of prostate-specific antigen (PSA) testing, which plays a crucial role in detecting prostate cancer (PCa) in an aged population, is low in Korea. Reflecting these epidemiologic characteristics, we estimated the short- and long-term incidences of PCa. A regression equation model was extracted based on two critical pieces of information: (1) the distribution of newly detected PCa cases in each age group of the 50s, 60s, 70s, and over 80s from a recent period (2006-2020), and (2) the PSA testing rate (PSAr) from the previous decade (2006-2016) for each age subgroup.

View Article and Find Full Text PDF

While simultaneous bilateral partial nephrectomy with a conventional multiport robot has been consistently reported since the 2010s, the introduction of the DaVinci SP system (Intuitive Surgical, Sunnyvale, CA, USA) could provide a novel way to perform surgery on bilateral kidneys while innovatively reducing the number of incisions. In our first report worldwide, the patient with bilateral small renal mass (2.0 cm for the left and 1.

View Article and Find Full Text PDF

Purpose: To investigate the long-term effects of taking 5-alpha reductase inhibitors (5ARIs) on the development of bladder cancer (BC) and the implementation of radical cystectomy (RC), a standard procedure for advanced BC.

Materials And Methods: From the National Health Insurance Sharing Service database, males aged over 40 years who underwent serum prostate-specific antigen testing from 2006 through 2017 were identified, which is required for the prescription of 5ARIs. The association between the administration duration of 5ARIs and the practice for BC was analyzed.

View Article and Find Full Text PDF
Article Synopsis
  • The study evaluated the effectiveness of ibrutinib for treating relapsed or refractory mantle cell lymphoma (MCL) in a group of 42 patients, showing a 69% overall response rate with notable survival outcomes.
  • Key findings include a median progression-free survival of 16.4 months and overall survival of 50.1 months, but older patients and those with certain risk factors had worse outcomes.
  • The study emphasizes the need to assess patient characteristics before using ibrutinib and suggests that early relapse indicates a need for new treatment options.
View Article and Find Full Text PDF
Article Synopsis
  • Atmospheric deposition of nitrogen, particularly as NO and NH in airborne particles, is a key nutrient source for ecosystems.
  • Research conducted in the Yellow Sea revealed that offshore concentrations of these nitrogen compounds were influenced by pollution transported from developed areas in Korea and China, with measurements showing approximately 88 and 102 nmol/m respectively.
  • The inshore site exhibited nitrogen concentrations that were about twice those of the offshore site, indicating that overall atmospheric nitrogen deposition contributes roughly 10% to new biological production in the Yellow Sea.
View Article and Find Full Text PDF

Accurately constraining the natural variability of the carbonate system is essential for evaluating long-term changes in coastal areas, which result from the absorption of anthropogenic CO. This is particularly important given the significant variation in physical and biological processes in these regions. In this regard, the analysis of surface carbonate chemistry in the Yellow Sea was conducted using discrete seawater samples obtained from the Socheongcho Ocean Research Station (37.

View Article and Find Full Text PDF

Our understanding of the impact of atmospheric acid deposition on marine carbonate system remains limited, largely due to a lack of data regarding acidity present in atmospheric particles and precipitation. Previous research has relied on the electroneutrality-based ion balance method for indirect estimation of atmospheric acidity. In this study, atmospheric samples collected at a coastal site of South Korea were mixed with seawater to measure the change in seawater total alkalinity (ΔTA) associated with atmospheric proton loading.

View Article and Find Full Text PDF

Aggregation and fibrillization of transthyretin (TTR) is a fatal pathogenic process that can cause cardiomyopathic and polyneuropathic diseases in humans. Although several therapeutic strategies have been designed to prevent and treat related pathological events, there is still an urgent need to develop better strategies to improve potency and wider applicability. Here, we present our study demonstrating that 3-iodothyronamine (T1AM) and selected thyronamine-like compounds can effectively prevent TTR aggregation.

View Article and Find Full Text PDF

Lipid metabolism and glycolysis play crucial roles in the progression and metastasis of cancer, and the use of 3-bromopyruvate (3-BP) as an antiglycolytic agent has shown promise in killing pancreatic cancer cells. However, developing an effective strategy to avoid chemoresistance requires the ability to probe the interaction of cancer drugs with complex tumor-associated microenvironments (TAMs). Unfortunately, no robust and multiplexed molecular imaging technology is currently available to analyze TAMs.

View Article and Find Full Text PDF
Article Synopsis
  • Primary testicular lymphoma, mainly diffuse large B cell lymphoma (DLBCL), is rare and poses challenges like central nervous system (CNS) recurrence despite established treatment protocols.
  • A study of 65 patients showed that those with stage I disease and a low prognostic score had better survival, and effective treatments included orchiectomy, chemotherapy, and radiation therapy.
  • CNS recurrence occurred in 15% of patients without identifiable risk factors, indicating a need for improved prevention strategies beyond current therapies.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionaron5ouatcm70currv2qaa914r39a4j4): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once