Estimation of bottom microplastic flux in the Indonesian seas.

Marine debris, particularly microplastics, is an important environmental problem for Indonesia, impacting vast coastline and diverse marine ecosystems. However, little is known about the microplastics flux to the seafloor in the Indonesian Seas. This study employs HYCOM data and Lagrangian particle tracking model to analyze the distribution of microplastics flux to the seafloor from 68 rivers in Indonesia.

Factors associated with the efficacy of first-line nivolumab plus chemotherapy in advanced gastric cancer patients with deficient mismatch repair.

Background: We aimed to investigate clinicopathologic factors leading to different clinical outcomes in patients with deficient mismatch repair protein (d-MMR) gastric cancer (GC) treated with nivolumab plus chemotherapy (nivolumab chemotherapy).

Methods: This retrospective study included 28 patients with d-MMR advanced GC treated with first-line nivolumab chemotherapy. As a control group, 68 treated with first-line chemotherapy alone were included.

Organ-specific response with first-line atezolizumab-bevacizumab versus lenvatinib for patients with advanced hepatocellular carcinoma.

Background: Immune checkpoint inhibitor (ICI)-based treatments have become the mainstay of first-line treatment for unresectable hepatocellular carcinoma (HCC), but there has been a concern that intrahepatic HCC lesions may be less responsive to ICI monotherapy. We aimed to investigate the organ-specific response patterns among unresectable HCC patients treated with first-line atezolizumab-bevacizumab or lenvatinib.

Methods: This retrospective study included 386 patients with Child-Pugh A unresectable HCC who were treated with first-line atezolizumab-bevacizumab (n = 217) or lenvatinib (n = 169).

Tracking the pumice rafts from the Fukutoku-Okanoba submarine volcano with Satellites and a Lagrangian Particles trajectory model.

On August 13th, 2021, the Fukutoku-Okanoba, a submarine volcano in the Northwest Pacific Ocean, erupted. Satellites detected various pumice rafts that had drifted westward to reach southern Japan over two months. To cope with the potential danger from pumice rafts, predicting their trajectories is crucial.

Spatio-temporal structures of satellite-derived water quality indicators along the Korean South Coast.

The structure of 9-year time series data for Sea Surface Temperature (SST), Chlorophyll a (Chl-a) and Total Suspended Solids (TSS), derived from the Visible Infrared Imaging Radiometer Suite (VIIRS), was examined in this study. Authors found that there exists strong seasonality among the three variables with spatial heterogeneity along the Korean South Coast (KSC). In specific, SST was in phase with Chl-a, but out of phase with TSS by six months.

Holocene centennial variability in sea surface temperature and linkage with solar irradiance.

The climate periodically fluctuates on various time scales, however, there remains a lack of consensus on the centennial-scale variabilities and associated driving force. A continuous high-resolution sea surface temperature (SST) record allows for the detection of centennial-scale fluctuations. This study presents a high-resolution SST record covering the last 10,000 years based on the analysis of the alkenone unsaturation index in marine sediment cores off the southwest coast of the Korean Peninsula.

Underwater hidden microplastic hotspots: Historical ocean dumping sites.

Three ocean dumping sites located in the Yellow Sea (YS) and East Sea (ES) of South Korea have accumulated terrestrial waste from 1988 to 2015. Most of this waste comprised industrial wastewater and sewage sludge, which are sources of microplastics. In this study, we investigated the spatiotemporal distribution and characteristics of microplastics in surface and core sediments of the YS, South Sea (SS) and ES, including at dumping sites (YDP and EDP).

Super enhancers define regulatory subtypes and cell identity in neuroblastoma.

Half of the children diagnosed with neuroblastoma (NB) have high-risk disease, disproportionately contributing to overall childhood cancer-related deaths. In addition to recurrent gene mutations, there is increasing evidence supporting the role of epigenetic deregulation in disease pathogenesis. Yet, comprehensive cis-regulatory network descriptions from NB are lacking.

Tracking flood debris using satellite-derived ocean color and particle-tracking modeling.

Flood debris associated with Typhoon Lionrock from the Tumen River at the border between Russia and North Korea was traced using ocean color and a Lagrangian particle-tracking model. As debris is transported along with discharged water during floods, a means of tracing floodwater should also allow any associated debris to be tracked. By analyzing the anomalous distribution of colored dissolved organic matter (CDOM) and total suspended sediments (TSS) from the Geostationary Ocean Color Imager (GOCI), the southward movement of the floodwater was tracked along the eastern coast of the Korean Peninsula.

Destination of floating plastic debris released from ten major rivers around the Korean Peninsula.

Using a Lagrangian particle tracking model the coastal accumulation of debris from 10 major Chinese and Korean rivers discharging to the seas around the Korean Peninsula is investigated. The amount of debris from each river is proportional to the population over the catchment area of the river and the mismanaged plastic waste (MPW) ratio of the country the river belongs to. The debris generally washes up on the coast near the originating river mouth.

Potential predictability of skipjack tuna (Katsuwonus pelamis) catches in the Western Central Pacific.

The Pacific Island countries have a substantial socio-economic dependency on fisheries. Skipjack tuna is one of the most important species in the Western Central Pacific (WCP) and its catches in this region exhibit a spatio-temporal variability influenced by ocean conditions, mainly the El Niño-Southern Oscillation (ENSO). This study investigates the relationship between skipjack tuna catch amounts and environmental variables in the equatorial Pacific during 1990-2014, and evaluates the potential predictability of the catches based on their statistical relationship.

Application of satellite remote sensing in monitoring dissolved oxygen variabilities: A case study for coastal waters in Korea.

Dissolved oxygen (DO) is one of the critical parameters representing water quality in coastal environments. However, it is labor- and cost-intensive to maintain monitoring systems of DO since in situ measurements of DO are needed in high spatial and temporal resolution to establish proper management plans of coastal regions. In this study, we applied statistical analyses between long-term monitoring datasets and satellite remote sensing datasets in the eastern coastal region of the Yellow Sea.

Association between body mass index and mortality in the Korean elderly: A nationwide cohort study.

The objective of this study was to investigate the relationship between body mass index (BMI) and mortality in the elderly. This study was a nation-wide population-based retrospective cohort study of the National Health Insurance System-Senior Database (NHIS-SD). In this study, a total of 75,856 subjects were identified and selected from among 251,593 individuals aged ≥ 65 years who underwent health screening at least once between 2009 and 2012 and who had no history of diabetes, cardiovascular disease, stroke, cancer, or chronic obstructive pulmonary disease (COPD).

Association between serum ferritin and hemoglobin levels and bone health in Korean adolescents: A nationwide population-based study.

It is important to identify risk factors for low bone mass at a young age. An influence of iron store on bone health in the general population has been reported but has not been studied in adolescents. This study aimed to investigate the relationship between hemoglobin and serum ferritin levels and bone mineral content (BMC) in South Korean adolescents.

Polymorphism Interacts with Childhood Maltreatment in Determining Anxiety Sensitivity by Sex: A Preliminary Study in Healthy Young Adults.

Objective: Recent studies have reported associations of retinoid-related orphan receptor alpha () gene single nucleotide polymorphisms (SNPs) with depression and anxiety disorders. Based on these, we attempt to test whether polymorphism is associated with anxiety sensitivity (AS), the intermediate phenotype of depression and anxiety disorders. Considering gene-environment interactions and sex differences in AS, childhood maltreatment (CM) and sex were considered as confounders.

Lethal and sub-lethal effects of elevated CO2 concentrations on marine benthic invertebrates and fish.

Concern about leakage of carbon dioxide (CO2) from deep-sea storage in geological reservoirs is increasing because of its possible adverse effects on marine organisms locally or at nearby coastal areas both in sediment and water column. In the present study, we examined how elevated CO2 affects various intertidal epibenthic (benthic copepod), intertidal endobenthic (Manila clam and Venus clam), sub-tidal benthic (brittle starfish), and free-living (marine medaka) organisms in areas expected to be impacted by leakage. Acute lethal and sub-lethal effects were detected in the adult stage of all test organisms exposed to varying concentrations of CO2, due to the associated decline in pH (8.

Postmarketing surveillance study of the efficacy and safety of phentermine in patients with obesity.

Background: Obesity is a complex problem that is now considered a chronic metabolic disease. In Korea, phentermine has been widely used for the treatment of obesity in the primary care setting since 2004. However, there have been very few studies on the safety and efficacy of phentermine.