Publications by authors named "Young A Lee"

Video exposure is known to affect brain function, yet its impact on neurodevelopmental processes remains unclear. This study aimed to investigate whether exposure to a video depicting social behavior induces behavioral and neurological changes in socially isolated mice. On Postnatal Day (PND) 21, male mice were separated from their dams and randomly assigned to three groups: socially grouped mice; socially isolated mice (ISO), where mice were housed without any social stimulation; and social video-exposed mice (SVE), where mice were exposed to a social video played on a tablet from PND21 to PND56 under socially isolated conditions.

View Article and Find Full Text PDF

Purpose: Few data on the clinical course after levothyroxine (L-T4) discontinuation in pediatric patients with Hashimoto thyroiditis (HT) are available. We investigated outcomes and predictors for successful withdrawal from L-T4 among children with HT.

Methods: Among 168 patients diagnosed with HT between January 2000 and March 2021 at Seoul National University Children's Hospital and in whom L-T4 therapy was initiated during childhood, we attempted to discontinue this therapy in 47, 3 boys and 44 girls.

View Article and Find Full Text PDF
Article Synopsis
  • - The study focuses on twin pregnancies resulted from assisted reproductive technology, especially in older women, highlighting their higher risk of chemical exposure to per- and polyfluoroalkyl substances (PFAS), which can affect fetuses.
  • - Researchers analyzed PFAS levels in 78 maternal and 156 cord serum samples, finding higher PFAS concentrations in mothers, while certain chemicals were more prevalent in newborns, suggesting uneven exposure during pregnancy.
  • - Results showed that while twin pregnancies don't change PFAS exposure levels or transfer efficiency compared to singletons, maternal PFAS levels were linked to complications and varied cord levels in twins, indicating a need for more research on potential health impacts.
View Article and Find Full Text PDF

Objective: Hepatopulmonary syndrome (HPS) is a rare complication of metabolic associated fatty liver disease (MAFLD) occurring subsequent to hypopituitarism, often developing after resection of hypothalamic or pituitary tumors. The aim of this study is to report an illustrative case of an HPS patient who was successfully treated with growth hormone replacement therapy, without liver transplantation which is conventionally regarded as the only treatment option. Additionally, we conducted a comprehensive review of published case reports of HPS in the pediatric population.

View Article and Find Full Text PDF

Floating microplastics (MPs) have recently become a major concern in marine pollution; however, current filter-based technology is hardly effective for directly removing such MPs from the water surface because of specific mesh size and clogging issues. This paper introduces a new skimming concept for removing floating MPs utilizing capillary force mediated by the elevation of a hydrophilic ratchet at the air-water interface. MPs floating near the ratchet surface are spontaneously forced toward the ratchet with a concave water meniscus, driven by the Cheerios effect.

View Article and Find Full Text PDF

Nanoplastics (NPx) can enter living organisms, including humans, through ecosystems, inhalation, and dermal contact and can be found from the intestine to the brain. However, it is unclear whether NPx accumulates and affects the dopamine system. In this study, we investigated the effects of NPx on the dopamine system in cultured murine cerebral cortex neurons.

View Article and Find Full Text PDF

Background: Parkinson's disease (PD) is a neurodegenerative disorder caused by dopamine (DA) neuronal dysfunction. Although DA agonists and N-methyl-D-aspartate receptor (NMDAR) antagonists are used to treat PD, chronic use causes severe side effects. Puerarin (PUE) is a natural bioactive compound that affects the DA system; however, its effect on PD-associated motor functions is unknown.

View Article and Find Full Text PDF

Recent advancements in next-generation sequencing (NGS) technologies have created new opportunities for comprehensive screening of multiple parasite species. In this study, we cloned the 18 S rDNA V9 region of 11 species of intestinal parasites into plasmids. Equal amounts and concentrations of these 11 plasmids were pooled, and amplicon NGS targeting the 18 S rDNA V9 region was performed using the Illumina iSeq 100 platform.

View Article and Find Full Text PDF
Article Synopsis
  • A study examined how early life exposure to fine particulate matter (PM) and nitrogen dioxide (NO) affects thyroid function in children, focusing on their levels of thyrotropin, triiodothyronine, and free thyroxine.
  • Results indicated that increases in PM exposure during the first trimester were linked to lower thyrotropin levels in children at ages 4 and 6.
  • Conversely, childhood PM exposure was positively associated with higher thyrotropin levels at ages 4 and 6 and negatively related to free thyroxine levels at age 8, suggesting the importance of timing in understanding these effects.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how exposure to endocrine-disrupting chemicals (EDCs) during pregnancy and childhood affects early breast development (thelarche) in girls, specifically before age 8.
  • Researchers analyzed data from 211 girls, focusing on chemicals like cadmium, lead, mercury, bisphenol-A (BPA), and others from prenatal samples and assessed breast development through Tanner staging.
  • Results revealed that higher prenatal exposure to cadmium increased the likelihood of early thelarche, while prenatal exposure to BPA appeared to lower this risk; however, no significant associations were found with chemical exposures at age 8.
View Article and Find Full Text PDF

We previously reported that leukotriene B4 (LTB4) contained in Trichomonas vaginalis-derived secretory products (TvSP) play an essential role in interleukin-8 (IL-8) production in human mast cell line (HMC-1 cells) via LTB4 receptor (BLT)-mediated Nuclear Factor-kappa B (NF-кB) activation. Dynamin, a GTPase, has been known to be involved in endocytosis of receptors for signaling of production of cytokine or chemokines. In the present study, we investigated the role of dynamin-mediated BLT1 endocytosis in TvSP-induced IL-8 production.

View Article and Find Full Text PDF

Trichomoniasis is caused by a sexually transmitted flagellate protozoan parasite Trichomonas vaginalis. T. vaginalis-derived secretory products (TvSP) contain lipid mediators such as leukotriene B4 (LTB4) and various cysteinyl leukotrienes (CysLTs) which included LTC4, LTD4, and LTE4.

View Article and Find Full Text PDF

This study aimed to elucidate the effects of sucrose (SUC) consumption on neurodevelopmental processes through behavioral changes in rodents and determine whether these effects could be because of sweet taste, energy supply, or both. Mice were divided into five groups based on the time of SUC or sucralose (SUR, a noncaloric sweetener) administration: for 6 days from gestation day (GTD) 7, to birth from GTD13 and for 15 days from postnatal day (PND) 21, PND38, and PND56. SUC and SUR administration did not impact body weight.

View Article and Find Full Text PDF

Background: This study investigated the association of prenatal and early childhood exposure to air pollution with epigenetic age acceleration (EAA) at six years of age using the Environment and Development of Children Cohort (EDC Cohort) MATERIALS & METHODS: Air pollution, including particulate matter [< 2.5 µm (PM) and < 10 µm (PM) in an aerodynamic diameter], nitrogen dioxide (NO), ozone (O), carbon monoxide (CO), and sulfur dioxide (SO) were estimated based on the residential address for two periods: 1) during the whole pregnancy, and 2) for one year before the follow-up in children at six years of age. The methylation levels in whole blood at six years of age were measured, and the methylation clocks, including Horvath's clock, Horvath's skin and blood clock, PedBE, and Wu's clock, were estimated.

View Article and Find Full Text PDF

Exposure to environmental microplastics has been demonstrated to impact health. However, its effect on development remains unclear. This study investigated whether consumption of nanoplastics (NPx) during development affects social and cognitive functions in rodents.

View Article and Find Full Text PDF
Article Synopsis
  • A study evaluated the clinical outcomes of pediatric craniopharyngiomas (CRPs) and the importance of anatomical classification, particularly related to the diaphragm sellae, for surgical planning.
  • 132 patients under 18 who underwent surgery for CRPs between 1998 and 2022 were analyzed, categorized by surgical approach: transcranial (TCA), transsphenoidal (TSA), and endoscopic endonasal (EEA).
  • Results showed that TSA was more effective than TCA in specific cases, and after EEA's introduction, more supradiaphragmatic CRPs were treated via TSA. Individualized surgical strategies, including complete tumor removal and adjuvant therapy, significantly improved long
View Article and Find Full Text PDF

Objective: This study aimed to assess selenium status in South Korean pregnant women and its impact on maternal thyroid function and pregnancy outcomes.

Methods: 'Ideal Breast Milk (IBM) Cohort Study' included 367 pregnant women out of 442 participants and categorized into three groups based on plasma selenium levels: deficient (< 70 μg/L), suboptimal (70-99 μg/L), and optimal (≥ 100 μg/L). During the second or third trimester, various blood parameters, including selenium, thyroid-stimulating hormone, free T4, free T3, and anti-thyroid peroxidase antibody levels, were measured.

View Article and Find Full Text PDF

Self-assembly of M(ClO) (M = Ni, Cu, and Zn) with (1,1',1'',2,2',2'')-(benzenetricarbonyltris(azanediyl))tris(2,3-dihydro-1-indene-2,1-diyl) trinicotinate (,-L) and the corresponding enantiomer (,-L) as a pair of chiral tridentate donors gives rise to the chiral cage pairs [M(,- and ,-L)](ClO). For the two pairs of [(MeCO)(HO)@M(,- and ,-L)](ClO) (M = Ni and Zn), the inner cavity is occupied by both an acetone and a single water molecule, whereas for the copper(II) pair of [MeCO@Cu(,- and ,-L)](ClO) under the same conditions, the cavity is filled by only one acetone molecule. Thus, the encapsulation of guest molecules into the cages during self-assembly shows significant metal(II) ion effects.

View Article and Find Full Text PDF

The self-assembly of NiCl with a chiral bidentate ligand pair, (1,2)-(+)- and (1,2)-(-)-1-(nicotinamido)-2,3-dihydro-1-inden-2-yl nicotinate (,-L and ,-L) in a mixture of ethanol and dioxane, gives rise to stable crystals consisting of [2Cl@NiCl(,-L)(HO)]·4CHO·EtOH and [2Cl@NiCl(,-L)(HO)]·4CHO·EtOH chiral cages, respectively, with two encapsulated chloride anions in the cavities. The most interesting feature is that the self-assembly of NiCl with the mixture of ,-L and ,-L (1 : 1-1 : 4) produces crystals of thermodynamically stable achiral cages, [2Cl·2HO@NiCl(,-L)(,-L)(HO)]·7CHO, in the molar ratio range. Furthermore, the [2Cl@NiCl(,-L)(HO)]·4CHO·EtOH and [2Cl@NiCl(,-L)(HO)]·4CHO·EtOH chiral crystals can recognize the pairs of L-,D-tryptophan and L-,D-cysteine cyclic voltammetry (CV) signals, in contrast to the [2Cl·2HO@NiCl(,-L)(,-L)(HO)]·7CHO achiral crystal.

View Article and Find Full Text PDF

Background: Familial chylomicronemia syndrome (FCS) is a rare monogenic form of severe hypertriglyceridemia, caused by mutations in genes involved in triglyceride metabolism. Herein, we report the case of a Korean family with familial chylomicronemia syndrome caused by compound heterozygous deletions of glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1).

Case Presentation: A 4-year-old boy was referred for the evaluation of severe hypertriglyceridemia (3734 mg/dL) that was incidentally detected 4 months prior.

View Article and Find Full Text PDF
Article Synopsis
  • Bisphenol S (BPS) and Bisphenol F (BPF), substitutes for the endocrine disruptor Bisphenol A (BPA), were studied for their effects on children's body composition and hormone levels.
  • In a cohort of 561 children aged 6 and 8, higher urinary levels of BPS and BPF were linked to increased BMI, fat mass, and altered serum adipokine levels, specifically lower adiponectin and higher leptin.
  • The study concludes that exposure to BPS and BPF may have negative impacts on children's obesity-related measures, raising concerns over the safety of these BPA substitutes.
View Article and Find Full Text PDF

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive joint inflammation, resulting in cartilage destruction and bone erosion. It was reported that low-dose radiation modulates immune disease. Here, we investigated whether low-dose whole-body irradiation has preventive and therapeutic effects in collagen-induced RA (CIA) mouse models.

View Article and Find Full Text PDF

This study investigates the impact of gonadotoxic cancer treatment on treatment-related amenorrhea (TRA) and hormonal status in pediatric and adolescent females who underwent fertility preservation (FP) consultation. A retrospective review was conducted on 143 females under 21 with cancer referred to the FP clinic at Seoul National University Hospital between 2011 and 2022. We analyzed variables, including age, menarche status, cancer type, and treatment.

View Article and Find Full Text PDF

Entamoeba histolytica is an enteric tissue-invasive protozoan parasite causing amoebic colitis and liver abscesses in humans. Amoebic contact with host cells activates intracellular signaling pathways that lead to host cell death via generation of caspase-3, calpain, Ca2+ elevation, and reactive oxygen species (ROS). We previously reported that various NADPH oxidases (NOXs) are responsible for ROS-dependent death of various host cells induced by amoeba.

View Article and Find Full Text PDF

Objective: Adequate iodine intake is essential for growing children, and thyroid volume (Tvol) is considered as an indicator of iodine status. We investigated Tvol and goiter using ultrasonography (US) and their association with iodine status in 228 6-year-old children living in Korea.

Methods: Iodine status was assessed using urine iodine concentration (UIC) and categorized as deficient (<100 μg/L), adequate (100-299 μg/L), mild excess (300-499 μg/L), moderate excess (500-999 μg/L), and severe excess (≥1000 μg/L).

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: