Publications by authors named "Youness Ahellal"
Collecting duct carcinoma (CDC) of the kidney is a rare and aggressive malignant tumor arising from the distal collecting tubules which has been shown to have a poor response to several kinds of systemic therapy. We present a case of metastatic CDC that responded favorably to a multiple tyrosine kinase inhibitor, sunitinib, achieving a partial response in both lung and skeletal metastases. To our knowledge, this is the first report showing therapeutic activity of sunitinib against CDC.
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- Focuses on targeted therapies for non-clear cell renal cell carcinoma (RCC), detailing the unique genetic profiles of subtypes like papillary and chromophobe that influence treatment options.
- Reviews clinical trials from 2000 to 2010 to assess the availability and effectiveness of targeted therapies specifically for non-clear RCC, noting a lack of robust research in this area.
- Concludes that advanced non-clear RCC patients should be thoroughly evaluated for surgical options and highlights that sunitinib is a tolerable and effective treatment for these patients.