Synthesis and characterization of 2-(anthracene-9-yl)-4,5-diphenyl-1-imidazole derivatives as environmentally sensitive fluorophores.

2-(Anthracene-9-yl)-4,5-diphenyl-1-imidazole (ADPI) provides an intriguing molecular platform for developing organic fluorophores with diverse properties and fluorescence performances. However, derivatives of ADPI have not yet been well explored and extensive studies are warranted. To shed more light on this, we have synthesized a series of π-extended ADPIs through a concise synthetic route involving an efficient cross-condensation reaction followed by Pd-catalyzed Suzuki cross-coupling.

Production of sheep wool keratin hydrolysate and evaluation of its effectiveness in promoting maize cultivation.

The purpose of this work is to produce keratin hydrolysate from sheep wool by alkaline hydrolysis and to assess its effectiveness in improving maize plant growth under greenhouse conditions. A hybrid response surface methodology with Box-Behnken design (RSM-BBD) was used to model and optimize the hydrolysis process. The synergistic effects between three critical independent variables including temperature, hydrolysis time, and concentration of KOH on the hydrolysis rate were statistically investigated and optimized.

Electron-donating arene-substituted pentacenedione derivatives: a study of structural, electronic, and electrochemical properties.

A new series of redox-active tetraryl-substituted pentacenedione derivatives, namely Ar4-PDs, was prepared through Suzuki-Miyaura coupling reactions between a bis(dibromomethane)pentacenedione and various arene boronic acids. Single-crystal X-ray diffraction analysis and density functional theory (DFT) calculations have confirmed that these Ar4-PDs possess highly twisted conformations due to the significant steric encumbrance between the Ar substituents and the anthraquinodimethane moiety. Cyclic voltammetric analysis revealed that the nature of the Ar group critically influences the redox properties of Ar4-PDs.

Carotid blood flow in abnormal head posture: a prospective observational study exploring facial asymmetry in strabismus.

Purpose: To investigate whether abnormal head posture (AHP) induces changes in common carotid artery blood flow (CCBF), thereby leading to the development of facial asymmetry in the setting of strabismus and ocular torticollis.

Methods: This was a prospective observational study of pediatric subjects in an urban ophthalmology clinic who underwent bilateral carotid artery ultrasound examination with spectral Doppler in an upright, straight-head posture and with a head tilt of 30°-45° to the right and left. The primary outcome was change in carotid flow on the side of the head tilt.

Erythropoietin in Acute Kidney Injury (EAKI): a pragmatic randomized clinical trial.

Background: Treatment with erythropoietin is well established for anemia in chronic kidney disease patients but not well studied in acute kidney injury.

Methods: This is a multicenter, randomized, pragmatic controlled clinical trial. It included 134 hospitalized patients with anemia defined as hemoglobin < 11 g/dL and acute kidney injury defined as an increase of serum creatinine of ≥ 0.

An efficient synthesis of furan-3(2)-imine scaffold from alkynones.

A novel efficient method to generate spiro furan-3(2)-imine derivatives is established by the reaction between the ,-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS).

Study of predictive factors of complete response after chemoembolization for unresectable hepatocellular carcinoma in 162 patients.

Aim Of The Study: To study clinical, laboratory and imaging features correlated with complete response (CR) to transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC) through 162 patients collected in Hassan II University Hospital of Fez.

Material And Methods: From January 2015 to December 2019, 162 patients diagnosed with 225 HCC were treated by TACE. Among them, 14 showed CR during the follow-up.

Physico-chemical changes in cladodes of Opuntia ficus-indica as a function of the growth stage and harvesting areas.

The physicochemical properties of cladodes Opuntia ficus-indica (OFI) vary widely during maturation. However, few studies have been performed to evaluate changes in chemical characteristics on the pad depending on the maturity stages. Chemical proximate analysis like the content of total sugars, protein, dry matter, pH, conductivity and ash, depending on the variation of weight of the pad and the growing region was done to determine the changes of characteristics of nopal.

Pyrenoimidazolyl-Benzaldehyde Fluorophores: Synthesis, Properties, and Sensing Function for Fluoride Anions.

Two structural isomers of (9-pyreno[4,5-]imidazol-10-yl)-benzaldehyde, with para and meta substitution patterns, were synthesized by condensation of 4,5-pyrenedione with terephthalaldehyde and isophthalaldehyde, respectively. These new pyrenoimidazole derivatives were characterized by single-crystal X-ray crystallography, UV-vis absorption spectroscopy, fluorescence spectroscopy, and cyclic voltammetry to elucidate their structural, solid-state packing, and electronic properties. Interactions of these compounds with fluoride anions in polar organic solvents (acetone and dimethyl sulfoxide) were investigated by NMR, UV-vis, and fluorescence techniques in conjunction with density functional theory calculations.

International consensus (ICON) on treatment of sudden sensorineural hearing loss.

Sudden sensorineural hearing loss (SSNHL) is a common and alarming symptom that often prompts an urgent visit to an ENT specialist. Treatment of SSNHL remains one of the most problematic issues for contemporary otorhinolaryngology: although many meta-analyses and national guidelines have been issued, management is not standardized in terms of medical treatment, and duration and route of administration. We present several methodological suggestions for the study of treatments for SSNHL.

Intracanalicular Vestibular Schwannomas: Initial Clinical Manifestation, Imaging Classification, and Risk Stratification for Management Proposal.

Introduction: There is no consensus about the use of observation as a therapeutic modality for intracanalicular vestibular schwannoma (ICVS). The objective of this study was to describe tumor evolution, its correlation with initial size, stage of vestibular schwannoma, clinical presentation and to propose a risk classification for tumor growth with a therapeutic decision algorithm.

Methods: Fifty-three patients with ICVS were followed prospectively from 2010 to 2015.

Transient Central Diabetes Insipidus and Marked Hypernatremia following Cardiorespiratory Arrest.

Central Diabetes Insipidus is often an overlooked complication of cardiopulmonary arrest and anoxic brain injury. We report a case of transient Central Diabetes Insipidus (CDI) following cardiopulmonary arrest. It developed 4 days after the arrest resulting in polyuria and marked hypernatremia of 199 mM.

Kinect2 - respiratory movement detection study.

Radiotherapy is one of the main cancer treatments. It consists in irradiating tumor cells to destroy them while sparing healthy tissue. The treatment is planned based on Computed Tomography (CT) and is delivered over fractions during several days.

Dithiafulvenyl-grafted phenylene ethynylene polymers as selective and reversible dispersants for single-walled carbon nanotubes.

Phenylene ethynylene-based π-conjugated polymers grafted with dithiafulvenyl groups on their side chains were found to be efficient in dispersing single-walled carbon nanotubes in a selective and controllable way.

Intradermal melanocytic nevus of the external auditory canal.

Intradermal nevi are common benign pigmented skin tumors. Their occurrence within the external auditory canal is uncommon. The clinical and pathologic features of an intradermal nevus arising within the external auditory canal are presented, and the literature reviewed.

Inhibition of murine renal carcinoma pulmonary metastases by systemic administration of interferon gamma: mechanism of action and potential for combination with interleukin 4.

We have previously demonstrated that IFN-gamma causes cell growth inhibition and up-regulation of MHC antigens in human renal cell carcinoma cell lines. In this study, we have investigated the therapeutic potential of IFN-gamma for the treatment of 5-day established pulmonary metastases induced by i.v.

[Transurethral vaporization of the prostate for benign hypertrophy: preliminary clinical and histological study].

Twenty five patients with symptomatic BPH and normal PSA underwent electrovaporization. The mean IPSS was 21.5 before and 7.

Local tumor irradiation augments the response to IL-2 therapy in a murine renal adenocarcinoma.

We have previously demonstrated that local tumor irradiation effectively enhanced the therapeutic effect of IL-2 therapy on pulmonary metastases from a murine renal adenocarcinoma, Renca. Irradiation with 300 rad to the left lung only, followed by systemic IL-2 therapy, results in increased tumor reduction in both lungs, suggesting that radiation enhances the systemic effect of immunotherapy. In this study, we show that irradiation of the tumor-bearing organ is essential for the combined effect of both modalities.

Radiation-induced effects on murine kidney tumor cells: role in the interaction of local irradiation and immunotherapy.

Local tumor irradiation enhances the effect of interleukin-2 (IL-2) therapy in the Renca murine renal adenocarcinoma model. To investigate the mechanism(s) of this interaction, we studied the in vitro and in vivo effects of irradiation on the tumor cells. Tumor cells from in situ irradiated renal tumors had diminished proliferation in vitro.

Intralesional treatment of established murine primary renal tumor with interleukin-4: localized effect on primary tumor with no impact on metastases.

In an effort to develop new strategies for immunotherapy of metastatic renal cell carcinoma, we investigated the therapeutic potential of interleukin-4 in a visceral renal tumor using the murine Renca renal adenocarcinoma model. Renca cells were implanted underneath the renal capsule of Balb/c mice to induce a primary tumor that spontaneously metastasized to several organs. Established primary renal tumors 4 to 6 mm.

Systemic treatment with interleukin-4 induces regression of pulmonary metastases in a murine renal cell carcinoma model.

Advanced metastatic renal cell carcinoma has been shown to be responsive to immunotherapy but the response rate is still limited. We have investigated the therapeutic potential of systemic interleukin-4 (IL-4) administration for the treatment of pulmonary metastases in the murine Renca renal adenocarcinoma model. Renca cells were injected iv in Balb/c mice to induce multiple pulmonary tumor nodules.

Expansion of activated lymphocytes obtained from renal cell carcinoma in an automated hollow fiber bioreactor.

Immunotherapy using IL-2 alone or combined with activated lymphocytes has been promising for metastatic renal cell carcinoma. Cytotoxic lymphocytes can be isolated from tumors, expanded in vitro with IL-2, and adoptively transferred back into the tumor-bearing host. These cells can also be transduced with the genes coding for cytokines for local delivery to tumor sites.