Publications by authors named "Youn Seo Oh"
Article Synopsis
- The brown alga Mi-Yoek, commonly eaten in East Asia, has been shown in studies to help with various health issues like inflammation and fat metabolism.
- Researchers explored how ethanol extracts from this alga (UP-Ex) impact human bone marrow mesenchymal stem cells (hBM-MSCs) and found that UP-Ex helps protect these cells from oxidative damage.
- Treatment with UP-Ex not only reduced oxidative stress but also improved the ability of aging hBM-MSCs to differentiate into other cell types, indicating it may enhance stem cell therapy effectiveness.
Alteration of DNA methylation is highly associated with aging and neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS). Remedying these aberrant methylation patterns may serve to improve these diseases. Previously, we reported that human bone marrow mesenchymal stromal cells isolated from ALS patients (ALS-MSCs) have functionally decreased stem cell potency, and excessively express DNA methyltransferases (DNMTs).
View Article and Find Full Text PDFAlteration of DNA methylation is highly associated with ageing and ageing-related diseases. Remedy of the altered methylation pattern may provide beneficial efficacy in these diseases. In this study, we used a DNA methyltransferase inhibitor, RG108, to investigate the senescence effects in human bone marrow mesenchymal stromal cells (hBM-MSCs).
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