Fermented with Improves Skin Barrier Properties, Moisturizing, and Anti-Inflammatory Responses.

root has been used as a traditional medicine in Asia. Recently, anti-melanogenic and anti-photogenic effects of fermented root (FAT) were identified. However, information about the anti-atopic dermatitis action of FAT is limited.

Suppressive Effect of Fermented Root Extract against Photoaging: Possible Involvement of Hemeoxygenase-1.

root has historically been used as a traditional medicine in Korea. Previous studies have identified the anti-melanogenic effects of the extract of root fermented by (FAT). This study investigated the protective effects of FAT against ultraviolet light B exposure (UVB; 30 mJ/cm) in HaCaT (human keratinocyte) or Hs68 (human foreskin fibroblast) skin cells.

Media Exchange Performance Test Using the Bradford Assay in an Automated Bioreactor Engineering Model for Space Experiments.

Life science research has been actively carried out in space for a long time using bioreactor equipment, in anticipation of manned space exploration and space tourism. Such studies have reported that the microgravity environment has a negative effect on the human body, including the musculoskeletal system, nervous system, and endocrine system. Bone loss and muscular atrophy are issues that need to be resolved before long-term exposure of the human body to a space environment.

Decursin and Z-Ligustilide in Root Extract Fermented by Display Anti-Pigment Activity in Melanoma Cells.

The anti-melanogenic effects of the extract of (AT) root and the extract of AT root fermented by (FAT) were investigated. These effects were determined by measuring the inhibitory activity of AT and FAT on melanin production in B16F10 melanocytes and with in vitro tyrosinase activity assays. The AT extract inhibited melanin production at concentrations above 250 μg/ml, and this inhibitory effect was significantly enhanced by the fermentation process with .

Bacteriomimetic poly-γ-glutamic acid surface coating for hemocompatibility and safety of nanomaterials.

Poly-γ-glutamic acid (PGA), a major component of the bacterial capsule, is known to confer hydrophilicity to bacterial surfaces and protect bacteria from interactions with blood cells. We tested whether applying a bacteriomimetic surface coating of PGA modulates interactions of nanomaterials with blood cells or affects their safety and photothermal antitumor efficacy. Amphiphilic PGA (APGA), prepared by grafting phenylalanine residues to PGA, was used to anchor PGA to reduced graphene oxide (rGO) nanosheets, a model of hydrophobic nanomaterials.

Enhanced Anti-inflammatory Effects of γ-irradiated Pig Placenta Extracts.

Porcine placenta extract (PPE) is known to possess anti-inflammatory properties owing to its high concentration of bioactive substances. However, the need to eliminate blood-borne infectious agents while maintaining biological efficacy raises concerns about the optimal method for sterilizing PPE. Therefore, the objective of this study was to compare the effects of the standard pressurized heat (autoclaving) method of sterilization with γ-irradiation on the anti-inflammatory effects of PPE.

Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells.

Inducible nitric oxide synthase (iNOS) has been shown to be frequently expressed in melanomas; up-regulation of this enzyme is though to be associated with tumor progression. In this study, we investigated whether diverse cytokines such as: IL-6, TNF-alpha, IL-1beta, IFN-gamma and IL6RIL6 (a highly active fusion protein of the soluble form of the IL-6R (sIL-6R) and IL-6) enhance the iNOS gene expression in B16/F10.9 murine metastatic melanoma cells.