Publications by authors named "Youn Ho Shin"
Background: An understanding of the phenotypes and endotypes of atopic dermatitis (AD) is essential for developing precision therapies. Recent studies have demonstrated evidence for the gut-skin axis in AD.
Objective: We sought to determine the natural course and clinical characteristics of AD phenotypes and investigate their mechanisms on the basis of multiomics analyses.
Background: Acute bronchiolitis is a common cause of hospitalization during infancy that carries significant morbidity and mortality rates.
Purpose: This study compared the efficacy of different treatment modalities for infants with bronchiolitis in terms of hospital stay and clinical severity scores.
Methods: The PubMed database was searched for relevant studies.
Article Synopsis
- This study analyzes data from over 19,000 Korean children hospitalized for severe respiratory infections and compares them to 191,690 unexposed children to investigate the link between early respiratory viral infections and asthma development.
- Findings indicate that children who experienced severe respiratory infections, including those caused by specific viruses like rhinovirus and influenza, had higher rates of asthma exacerbation and new asthma cases over nearly 8 years of follow-up.
- The research emphasizes that multiple hospitalizations for lower respiratory tract infections significantly increase the risk of asthma complications later in life.
Total airway mechanics and fractional exhaled nitric oxide levels of children living in banjihas (semi-basements).
Asian Pac J Allergy Immunol
July 2024
Article Synopsis
- A study in Korea found that children living in semi-basements, or banjihas, experience higher airway resistance and inflammation compared to those living on higher floors.
- Researchers assessed 575 fifth- and sixth-graders, measuring factors like airway resistance and inflammation while accounting for allergens and pollutants.
- The results showed that despite similar exposure to allergens and pollutants, children in banjihas had worse respiratory health, highlighting the need for better health focus in these living environments.
Background: There are only preliminary studies examining the associations of postnatal antibiotic exposure with food allergy in childhood, and the effect of antibiotic exposure in utero has not been resolved. Thus, we aimed to investigate the effect of prenatal and postnatal antibiotic exposure on the risk of food allergy in childhood.
Methods: Using the nationwide birth cohort in South Korea, all 3,163,206 infants (pairing mother; n = 2,322,735) born in South Korea between 2010 and 2017 were included in the analysis.
Background: Allergic rhinitis (AR) phenotypes in childhood are unclear.
Objectives: This study sought to determine AR phenotypes and investigate their natural course and clinical and transcriptomic characteristics.
Methods: Latent class trajectory analysis was used for phenotyping AR in 1050 children from birth through 12 years using a birth cohort study.
Background: We investigated the correlation between urine VOC metabolites and airway function in children exposed to anthropogenic volatile organic compounds (VOCs), notable pollutants impacting respiratory health.
Methods: Out of 157 respondents, 141 completed skin prick tests, spirometry, IOS, and provided urine samples following the International Study of Asthma and Allergies in Childhood (ISAAC)-related questions. Allergic sensitization was assessed through skin prick tests, and airway functions were evaluated using spirometry and impulse oscillometry (IOS).
Background: infection is common in the general population and may be followed by immune dysfunction, but links with subsequent autoimmune disease remain inconclusive.
Objective: To estimate the association of infection with the risk of subsequent autoimmune disease.
Methods: This retrospective cohort study examined the medical records of South Korean children from 01/01/2002 to 31/12/2017.
Background: Vaccine-associated anaphylaxis is a rare but life-threatening reaction that occurs within minutes to hours of exposure to allergens. As studies utilizing large-scale data to investigate this topic are limited, further research is needed to assess its burden, long-term trends, and associated risk factors so as to gain a comprehensive understanding of vaccine-associated anaphylaxis globally. Therefore, this study aimed to investigate the global burden of vaccine-associated anaphylaxis and related vaccines.
View Article and Find Full Text PDFArticle Synopsis
- The COCOA study looks at how allergic diseases in kids, like asthma and food allergies, develop from birth through childhood.
- It examines many factors, like genetics, environment, and family history, to understand how these allergies happen and what makes some kids more likely to get them.
- The study uses advanced science techniques to gather information and works with other research groups to create better treatments for kids with allergies.
Article Synopsis
- This study analyzes a large cohort of over 1.6 million children in Korea born between 2009 and 2015 to examine the protective effects of breastfeeding against hospital admissions.
- Findings reveal that children who were exclusively breastfed had a 15% lower hospital admission rate compared to those who were fully formula-fed, while partially breastfed children had a 12% lower admission rate.
- The protective benefits of breastfeeding appear to decrease as children age, highlighting the importance of promoting breastfeeding, especially for at least the first 6 months, as a key public health strategy.
Article Synopsis
- Rotavirus infection is a well-known cause of gastroenteritis in children, and it may trigger autoimmune diseases, but the relationship between these two is not fully understood.
- A population-matched cohort study in South Korea analyzed data from over 86,000 children hospitalized for rotavirus from 2002 to 2017 to assess the risk of later developing autoimmune conditions.
- The findings indicated that children who were hospitalized for rotavirus had a 24% higher risk of developing autoimmune diseases compared to those who were not exposed, with a follow-up period of around 12 years.
(1) Background: Feeding behavior habits have a pattern with a certain tendency during infancy. We aimed to identify the associations between feeding patterns in infancy and the subsequent 10-year childhood disease burden. (2) Methods: Data from 236,372 infants were obtained from the national health insurance and screening program records in South Korea.
View Article and Find Full Text PDFBackground: Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with allergic rhinitis and food allergy and cause high morbidity and mortality both in children and adults. This study aims to evaluate the global, regional, national, and temporal trends of the burden of asthma and AD from 1990 to 2019 and analyze their associations with geographic, demographic, social, and clinical factors.
Methods: Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2019, we assessed the age-standardized prevalence, incidence, mortality, and disability-adjusted life years (DALYs) of both asthma and AD from 1990 to 2019, stratified by geographic region, age, sex, and socio-demographic index (SDI).
Objective: The identification of allergic rhinitis (AR) in early life is important for the target of intervention. AR is caused by various environmental factors, including house dust mites. We investigated the relationship between the Dermatophagoides farinae (Der f)-IgE and eosinophil in mothers with AR at delivery and the eosinophil levels and AR incidence in children.
View Article and Find Full Text PDFBackground And Aims: Owing to 2018 expanded diagnostic criteria for eosinophilic esophagitis (EoE) and thus a possible increase in diagnosis, previous studies on the global incidence and prevalence of EoE may need to be updated. We aimed to describe global, regional, and national trends in the incidence and prevalence of EoE from 1976 to 2022 and analyze their associations with geographic, demographic, and social factors through a systematic review.
Methods: We searched the PubMed/MEDLINE, Embase, CINAHL, Google Scholar, and Cochrane databases from their inception dates to December 20, 2022, for studies that reported the incidence or prevalence of EoE in the general population.
Background And Objective: Preterm birth or fetal growth has been associated with reduced lung function and asthma during childhood in the general population. We aimed to elucidate whether prematurity or fetal growth has a significant influence on lung function or symptoms in children with stable asthma.
Methods: We included children with stable asthma who participated in the Korean childhood Asthma Study cohort.
Article Synopsis
- The study investigated how asthma symptoms and medication use develop over time in children, focusing on exacerbation frequency from birth to age 12.
- Researchers followed 531 children aged 7 to 10 to identify distinct asthma patterns based on their exacerbation rates and medication needs.
- Four asthma clusters were found, highlighting different characteristics and risk factors, which can help improve understanding and treatment of childhood asthma.
Little is known about the ongoing monkeypox (mpox) outbreak, and the clinical features of mpox in patients worldwide have not been rigorously analysed. Thus, we aimed to investigate the clinical features associated with mpox infection and understand the pathophysiology and characteristics of the disease. For this systematic review and meta-analysis, we searched PubMed/MEDLINE, Embase, CINAHL, Google Scholar, and the Cochrane Database of Systematic Reviews for articles published till 16 September 2022.
View Article and Find Full Text PDFAssociations of prenatal antibiotic exposure and delivery mode on childhood asthma inception.
Ann Allergy Asthma Immunol
July 2023
Background: Prenatal antibiotic exposure and delivery mode may affect the gut microbiome in early life and influence the development of childhood asthma, but the combined effect of these 2 factors is unknown.
Objective: To identify the individual and combined effects of prenatal antibiotic exposure and delivery mode on the development of asthma in children and the potential mechanisms underlying these associations.
Methods: A total of 789 children from the Cohort for Childhood Origin of Asthma and Allergic Diseases birth cohort study were enrolled.
Background: Although previous studies have provided data on early pandemic periods of alcohol and substance use in adolescents, more adequate studies are needed to predict the trends of alcohol and substance use during recent periods, including the mid-pandemic period. This study investigated the changes in alcohol and substance use, except tobacco use, throughout the pre-, early-, and mid-pandemic periods in adolescents using a nationwide serial cross-sectional survey from South Korea.
Methods: Data on 1,109,776 Korean adolescents aged 13-18 years from 2005 to 2021 were obtained in a survey operated by the Korea Disease Control and Prevention Agency.
Background: Although smoking is classified as a risk factor for severe COVID-19 outcomes, there is a scarcity of studies on prevalence of smoking during the COVID-19 pandemic. Thus, this study aims to analyze the trends of prevalence of smoking in adolescents over the COVID-19 pandemic period.
Methods: The present study used data from middle to high school adolescents between 2005 and 2021 who participated in the Korea Youth Risk Behavior Web-based Survey (KYRBS).