Publications by authors named "Youling Duan"
Background: Lipoprotein(a) (Lp(a)) is considered to be a causal risk factor of atherosclerotic cardiovascular disease (ASCVD), but whether there is an independent or joint association of Lp(a) and atherosclerotic plaque with ASCVD risk remains uncertain. This study aims to assess ASCVD risk independently or jointly conferred by Lp(a) and carotid atherosclerotic plaque.
Methods And Results: A total of 5471 participants with no history of cardiovascular disease at baseline were recruited and followed up for ASCVD events (all fatal and nonfatal acute coronary and ischemic stroke events) over a median of 11.
Article Synopsis
- The study investigates the relationship between lipoprotein(a) [Lp(a)] levels and the progression of carotid plaques, which can influence stroke risk, over a 10-year period among a group of 804 participants aged 45 to 74.
- It was found that individuals with elevated Lp(a) levels (≥50 mg/dL) had a higher risk of plaque progression—both total and vulnerable plaques—compared to those with lower levels (Lp(a) <50 mg/dL).
- The findings suggest that targeting elevated Lp(a) could be a potential strategy for stroke prevention by addressing plaque development and vulnerability.
Aim: Experimental studies report that intermediate-density lipoprotein (IDL), the precursor of low-density lipoprotein, promotes atherosclerotic plaque formation. However, whether IDL is involved in the development of atherosclerosis in humans is still unclear. The aim of this community-based study is to examine the association between IDL particle (IDL-P) concentrations and the 5-year progression of carotid atherosclerosis.
View Article and Find Full Text PDF