Publications by authors named "Youlin Qiao"

Background: There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance knowledge on reproductive -related risk factors for EOC in a large population of Asian women.

Methods: This study used pooled individual data from baseline questionnaires in 11 prospective cohorts (baseline years, 1958-2015) in the Asia Cohort Consortium.

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  • The study followed 3,681 healthy women aged 18-45 for over 5 years to investigate HR-HPV infections and their outcomes, using regular cervical testing and colposcopy for abnormal results.
  • Data indicated that younger women (18-26 years) had a higher incidence of persistent HR-HPV infections and cervical lesions (CIN2+) than mid-adult women (27-45 years), suggesting age-related differences in risk.
  • Despite lower rates of infection and lesions in mid-adult women, they still face a significant risk of acquiring HR-HPV infections that could lead to cervical issues, highlighting the need for continued monitoring.
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Background: CareHPV is a highly promising screening HPV assay that functions as a simplified and rapid point-of-care test, making it particularly well-suited for low-resource areas. It exhibits high sensitivity for detecting cervical precancerous lesions in cross-sectional study design. However, there is still limited evidence on the long-term protection of careHPV testing in the practical setting.

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Clinicians face increasing workloads in medical imaging interpretation, and artificial intelligence (AI) offers potential relief. This meta-analysis evaluates the impact of human-AI collaboration on image interpretation workload. Four databases were searched for studies comparing reading time or quantity for image-based disease detection before and after AI integration.

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Background: Persistent infection of high-risk human papillomavirus (HPV) can lead to cervical intraepithelial neoplasia, cervical cancer, and even death. HPV vaccination for girls aged 9-14 years can effectively prevent the occurrence of cervical cancer. Some Chinese provinces and cities have launched free HPV vaccination programs for school-age girls; however, due to the lack of supportive government policies, the high price and supply shortage of HPV vaccines, and vaccine hesitancy, some parents refuse to vaccinate their daughters.

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Background: It has been suggested that the association between body mass index and breast cancer risk differs between Asian women and Western women. We aimed to assess the associations between body mass index and breast cancer incidence in East Asian women.

Methods: Pooled analyses were performed using individual participant data of 319,189 women from 13 cohort studies in Japan, Korea, and China.

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Objective: The research focused on a comparative analysis of triage strategies for women with Atypical Squamous Cells of Undetermined Significance (ASC-US) before and after receiving the HPV vaccine, aiming to optimize cervical cancer prevention strategies, especially in resource-limited healthcare settings.

Materials And Methods: Between September 2018 and December 2023, 7,511 women aged 21 years or older who underwent liquid-based cytology for cervical cancer screening were recruited. Women diagnosed with ASC-US were included in the study.

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  • - The high cost of HPV vaccines in China significantly limits accessibility, making it harder to eliminate cervical cancer and worsening health inequality in the country.
  • - A model was used to analyze how different factors, like settings, types of vaccines, and payment thresholds, affect the cost-effectiveness of a government-funded HPV vaccination program over 100 years.
  • - To be cost-effective, HPV vaccine prices need to be reduced to $26-$36 per dose for a two-dose schedule; a cost-saving program would require prices as low as $5-$10, which would substantially increase the National Immunization Programme budget.
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Objective: The value of the transformation zone (TZ) is often overlooked in clinical settings. This study aims to assess TZ distribution, associated factors, and its impact on colposcopic diagnosis.

Methods: χ 2 tests were used to analyze demographics, clinical history, and tissue samples to examine the differences in TZ distribution.

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  • The LTFU study is officially recorded in the Chinese Clinical Trial Registry.
  • The registration number for the study is ChiCTR2100052313.
  • This registration ensures transparency and credibility in the research process.
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  • * Researchers found that the average age girls start their periods is about 14 years, but it has been getting younger over the past 100 years.
  • * Different countries showed different trends, with some like China having ups and downs, while others like Japan and Singapore had a steady decline in the average age.
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  • A study examined the impact of family history of lung cancer (FHLC) on lung cancer incidence and mortality among East Asian individuals, using data from 478,354 participants across 11 cohorts.
  • The findings indicated that having a family history of lung cancer increased the risk of developing lung cancer by 45%, affecting both men and women, and regardless of whether individuals were smokers or non-smokers.
  • Specific lung cancer types like adenocarcinoma and squamous cell carcinoma showed even higher associated risks, but there was no significant difference in risk based on sex, smoking status, or ethnicity.
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Cervical cancer is a severe threat to women's health. The majority of cervical cancer cases occur in developing countries. The WHO has proposed screening 70% of women with high-performance tests between 35 and 45 years of age by 2030 to accelerate the elimination of cervical cancer.

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Objective: The objective of this study was to assess the attitudes toward the Colposcopic Artificial Intelligence Auxiliary Diagnostic System (CAIADS) of colposcopists working in mainland China.

Methods: A questionnaire was developed to collect participants' sociodemographic information and assess their awareness, attitudes, and acceptance toward the CAIADS.

Results: There were 284 respondents from 24 provinces across mainland China, with 55% working in primary care institutions.

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Background: Cervical cancer (CC) and breast cancer (BC) threaten women's well-being, influenced by health-related stigma and a lack of reliable information, which can cause late diagnosis and early death. ChatGPT is likely to become a key source of health information, although quality concerns could also influence health-seeking behaviours.

Methods: This cross-sectional online survey compared ChatGPT's responses to five physicians specializing in mammography and five specializing in gynaecology.

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  • Cervical cancer remains a significant health issue in China, facing challenges such as limited access to screening and vaccination, especially in rural areas.
  • Cultural beliefs and healthcare disparities contribute to low awareness and reluctance to seek treatment among women.
  • Suggested approaches include enhancing community education, improving healthcare infrastructure, and implementing targeted vaccination and screening programs to better address local needs.
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Background: We analyzed the prevalence and genotype distribution of multiple- or single-type cervical human papillomavirus (HPV) infections in a population of women in mainland China.

Methods: PubMed, MEDLINE, and Chinese databases (CNKI, VIP, and Wan Fang) were searched for studies on HPV prevalence and the examination of this relationship. All analyses were performed using STATA (version 12.

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  • The study examines the relationship between body mass index (BMI) and the risks of developing colorectal cancer (CRC) and dying from it in the Asian population, highlighting rising obesity rates and CRC incidence.
  • The research pooled data from 17 cohort studies spanning from 1984 to 2002, with a median follow-up of 15.2 years and included nearly 620,000 participants for CRC incidence and over 650,000 for CRC-related mortality.
  • Results indicate that higher BMI significantly increases the risk of incident CRC, with greater risks seen for those classified as obese, especially for colon cancer compared to rectal cancer, and a similar pattern was noted for CRC-related deaths.
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Rationale And Objective: There is a notable absence of robust evidence on the efficacy of ultrasound-based breast cancer screening strategies, particularly in populations with a high prevalence of dense breasts. Our study addresses this gap by evaluating the effectiveness of such strategies in Chinese women, thereby enriching the evidence base for identifying the most efficacious screening approaches for women with dense breast tissue.

Methods: Conducted from October 2018 to August 2022 in Central China, this prospective cohort study enrolled 8996 women aged 35-64 years, divided into two age groups (35-44 and 45-64 years).

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Objectives: To determine the incidence of UI (urinary incontinence) and its subtypes in hypertensive women and examine the association between hypertension and new-onset UI.

Study Design: We conducted a cohort study on women aged ≥20 years in six regions of China. This cohort study was carried out from 2014 to 2016 at baseline, with follow-up completed in 2018.

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Background: This study aimed to measure the accuracy of optical coherence tomography (OCT) in the early diagnosis of high-grade cervical lesions and assess its diagnostic value in the triage of high-risk HPV infection.

Method: From Jan 2019 to Jan 2021, women who visited the gynecology clinics of 2 hospitals for colposcopy were invited to participate in this study. Women aged 35 to 64 years old who were sexually active and had an intact cervix with a diameter of more than or equal to 2 cm were included in this study.

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Cervical cancer is a major cause of morbidity and mortality globally with a disproportionate impact on women in low- and middle-income countries. In 2021, the World Health Organization (WHO) called for increased vaccination, screening, and treatment to eliminate cervical cancer. However, even with widespread rollout of human papillomavirus (HPV) prophylactic vaccines, millions of women who previously acquired HPV infections will remain at risk for progression to cancer for decades to come.

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Accumulating evidence has demonstrated that high-risk human papillomaviruses (HR-HPVs) are involved in the etiology of a subset of oropharyngeal squamous cell carcinoma (OPSCC). In this regard, the International Agency for Research on Cancer (IARC) has recommended direct molecular HPV testing. So far, there is no agreement on the most appropriate method for HPV detection on OPSCC formalin-fixed paraffin-embedded (FFPE) materials.

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