Publications by authors named "Youlin Fu"
As multiple imaging modalities cannot reliably diagnose cardiac tumors, the molecular approach offers alternative ways to detect rare ones. One such molecular approach is CRISPR-based diagnostics (CRISPR-Dx). CRISPR-Dx enables visual readout, portable diagnostics, and rapid and multiplex detection of nucleic acids such as microRNA (miRNA).
View Article and Find Full Text PDFStudy on the Mechanism of circRNA-0024103 Reducing Endothelial Cell Injury by Regulating miR-363/MMP-10.
Contrast Media Mol Imaging
August 2022
Article Synopsis
- Cardiovascular diseases, particularly atherosclerosis, pose significant health risks, underscoring the need for targeted therapies, yet the role of circRNA-0024103 in these diseases remains largely unknown.
- This study investigates how circRNA-0024103 affects the behavior of endothelial cells by modulating the miR-363/MMP-10 axis, specifically looking at proliferation, apoptosis, migration, and angiogenesis after exposure to ox-LDL.
- Results indicate that while overexpression of circRNA-0024103 enhances endothelial cell proliferation, migration, and tube formation, these effects can be diminished by introducing miR-363 mimics or MMP-10 siRNA, highlighting the complex regulatory role of circRNA-002
Noncoding RNAs are important for regulation of cardiac hypertrophy. The function of MALAT1 (a long noncoding mRNA), miR-181a, and HMGB2; their contribution to cardiac hypertrophy; and the regulatory relationship between them during this process remain unknown. In the present study, we treated primary cardiomyocytes with angiotensin II (Ang II) to mimic cardiac hypertrophy.
View Article and Find Full Text PDFLncRNA SNHG12 downregulates RAGE to attenuate hypoxia-reoxygenation-induced apoptosis in H9c2 cells.
Biosci Biotechnol Biochem
March 2021
Ischemia-reperfusion (I/R) injury causes cardiac dysfunction through several mechanisms including the irregular expression of some long noncoding RNA. However, the role of SNHG12 in myocardial I/R injury remains unclear. Here, we found the increase of the SNHG12 level in hypoxia-reoxygenation (H/R)-injured-H9c2 cells.
View Article and Find Full Text PDFBackground: The aim of this research is to further evaluate the efficacy and safety of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) complicated with chronic renal insufficiency (CRI) by meta-analysis, to provide scientific and effective medical evidence for PCI in patients with AMI complicated with CRI, and to support the clinical application of PCI.
Methods: Electronic databases will be searched, including PubMed, Cochrane Library, Embase, CNKI, CBM, VIP, and Wanfang Data. Patients with AMI complicated by renal insufficiency treated with PCI will be included.