Prognostic, oncogenic roles, and pharmacogenomic features of AMD1 in hepatocellular carcinoma.

Background: AMD1 is the gene encoding S-adenosylmethionine decarboxylase 1. How AMD1 affects the prognosis of hepatocellular carcinoma (HCC) patients is unclear.

Methods: Using the Cancer Genome Atlas (TCGA) liver hepatocellular carcinoma datasets, gene enrichment and immunological traits were compared between groups with high and low AMD1 expression.

Investigating the effect of history of fractures and hypertension on the risk of all-cause death from osteoporosis: A retrospective cohort study.

To assess the coexistence effect between history of fractures and hypertension on the all-cause death risk of osteoporosis. In this retrospective cohort study, some characteristics of osteoporosis patients aged ≥ 20 years were extracted from the National Health and Nutrition Examination Survey (NHANES) database (2005-2010, 2013-2014), such as age, gender, smoking, drinking, the history of diabetes, cardiovascular and cerebrovascular diseases, fractures and hypertension. The outcome of this study was defined as all-cause death of osteoporosis.

Pluronic F127-liposome-encapsulated curcumin activates Nrf2/Keap1 signaling pathway to promote cell migration of HaCaT cells.

Curcumin (CUR) is an extract of Curcuma longa Linn., which has various pharmacological activities. The instability, low water solubility and bioavailability of CUR greatly limit its clinical application.

Redispersible Reduced Graphene Oxide Prepared in a Gradient Solvent System.

We designed a gradient solvent strategy for the reduction of graphene oxide, matching the hydrophilic properties of graphene oxide (GO) and reduced graphene oxide (RGO), respectively. A third solvent was added dropwise to regulate the hydrophilic variation of the continuous gradient system which maintained the whole reduction process without aggregation, and the obtained RGO dispersions could maintain stability for a long time. The separated RGO solid powder can be directly ultrasonically redispersed in N-methyl-pyrrolidone (NMP) with an average particle size as low as 200 nm.

Study on Green Degradation Process of Polyurethane Foam Based on Integral Utilization and Performance of Recycled Polyurethane Oil-Absorbing Foam.

Ester exchange glycolysis of flexible polyurethane foam (PU) usually results in split-phase products, and the recovered polyether polyols are obtained after separation and purification, which can easily cause secondary pollution and redundancy. In this paper, we propose a green recycling process for the degradation of waste polyurethane foam by triblock polyether, and the degradation product can be used directly as a whole. The polyurethane foam can be completely degraded at a minimum mass ratio of 1.

Taohong Siwu decoction promotes the process of fracture healing by activating the VEGF-FAK signal pathway and systemically regulating the gut microbiota.

Aims: This study aimed to explore the effect of Taohong Siwu Decoction (THSWD) on bone marrow mesenchymal stem cells (BMSCs) at the cellular level and the possible mechanism of systemic regulation of gut microbiota on fracture recovery.

Methods And Results: Cell Counting Kit-8 (CCK-8) experiments show that THSWD effectively promotes the proliferation of BMSCs. Transwell and wound healing assays show that THSWD effectively promotes the invasion and migration of BMSCs.

Respiratory Adsorption of Organic Pollutants in Wastewater by Superhydrophobic Phenolic Xerogels.

Organogel adsorbents are widely used for the adsorption of hard-to-degrade organic pollutants in wastewater due to their natural affinity to the organic phase in water. In this study, phenolic xerogels (PF) synthesised in the ethylene glycol inorganic acid system are used as a backbone and superhydrophobic phenolic xerogels (ASO-PF) are obtained by grafting aminosilanes onto the PF backbone via the Mannich reaction. The modified ASO-PF not only retains the pore structure of the original PF (up to 90% porosity), but also has excellent superhydrophobic properties (water contact angle up to 153°).

The Prediction of Survival in Hepatocellular Carcinoma Based on A Four Long Non-coding RNAs Expression Signature.

Prognostic stratification in hepatocellular carcinoma (HCC) patients is still challenging. Long non-coding RNAs (lncRNAs) have been proven to play a crucial role in tumorigenesis and progression of cancers. The aim of this study is to develop a useful prognostic index based on lncRNA signature to identify patients at high risk of disease progression.

Hydrogel Cryopreservation System: An Effective Method for Cell Storage.

At present, living cells are widely used in cell transplantation and tissue engineering. Many efforts have been made aiming towards the use of a large number of living cells with high activity and integrated functionality. Currently, cryopreservation has become well-established and is effective for the long-term storage of cells.

Influence of sinomenine upon mesenchymal stem cells in osteoclastogenesis.

With the advent of aging, the morbidity rates of such diseases as osteoarthritis, rheumatoid arthritis, and osteoporosis has witnessed a significant increase. As a common rattan drug, sinomenine (SIN) has been widely applied for the treatment of various arthritic diseases in traditional Chinese medicine (TCM) clinics. Given that SIN has been reported to inhibit the expression of Prostaglandin E2 (PGE2) in several types of cells, in this study, the influence of SIN treatment on PGE2 expression in mesenchymal stem cells (MSCs), thereby changing the osteoprotegerin (OPG) receptor/activator for the nuclear factor-κ B ligand (RANKL) ratio, was investigated.