Publications by authors named "Youjin Han"
We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.
View Article and Find Full Text PDF[A preliminary study on the culture of single hematopoietic stem cell].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
February 2012
Article Synopsis
- The study aimed to analyze the survival and growth of specific stem cells (CD34 + CD38--Lin--) when cultured individually.
- Purified umbilical cord blood stem cells were tested across four experimental groups, including control and three treatments (Shh, BMP-4, and Jagged-1) to observe their behavior in single-cell culture over time.
- Results showed that treated cells had better survival and growth rates than control cells, with the Jagged-1 group performing the best, indicating that these factors promote the proliferation and self-renewal capabilities of stem cells.
Despite unsurpassed anti-tumor activity of bortezomib for multiple myeloma (MM), drug resistance has emerged as a challenge, especially when MM cells adhere to the stroma. This study aimed to determine whether bone marrow stromal cells (BMSCs) have a role in the development of chemoresistance in MM. Our data demonstrate that the secretion of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and cell-to-cell contact with microenvironment-derived stromal cells from patients with multiple myeloma (MM-BMSCs) significantly decreased the sensitivity of myeloma cells to bortezomib treatment.
View Article and Find Full Text PDFObjective: To investigate the role of mesenchymal stem cells (BMSCs) in multiple myeloma (MM) bone marrow (BM) microenrivonment and their effect on myeloma cells survival and bortezomib induced apoptosis.
Methods: BMSCs were derived from BM of untreated myeloma patients (MM-BMSCs) and healthy donors (HD-BMSCs), respectively. The phenotype, proliferation time and cytokine secretion of MM-BMSCs were detected and compared with HD-BMSCs.
Sjögren syndrome (SS) is a systemic autoimmune disease that mainly affects the salivary and lacrimal glands. It may exist as a primary condition or in association with other systemic autoimmune diseases. Patients with SS usually complain of persistent dryness of the mouth and eyes and other features, including diverse general symptoms and cutaneous symptoms such as purpura.
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