Publications by authors named "Youjeong Kim"

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  • CRISPR technology has changed genome editing but faces challenges with safe and efficient delivery methods for therapeutic uses.
  • The droplet cell pincher (DCP) microfluidic system offers a solution by enabling controlled and efficient delivery of CRISPR systems into cells, using mechanisms that create openings in cell membranes.
  • DCP has shown superior performance over traditional electroporation, achieving significantly higher success rates in genetic modifications like single and double knockouts and knock-ins, making it a promising tool for future CRISPR applications.
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  • * This study highlights the successful creation of stellate-shaped astrocytes from rat brain tissue using brain-derived decellularized extracellular matrix (bdECM) hydrogels, which provide a supportive and chemically active environment for the cells.
  • * The 3D bdECM culture not only induces mature astrocyte characteristics but also enhances their neurosupportive functions, as evidenced by improved neurite outgrowth and distinct gene expression profiles compared to traditional 2D cultures.
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The proliferation of online health communities creates opportunities to exchange social support. Given the growing need to investigate the extent to which social support helps mothers with postpartum depression (PPD) and psychological distress, we conducted a content analysis of 3,073 posts from a PPD-related message board in a prominent online community for Korean mothers. We found that community members tended to provide rather than seek support, indicating potential reciprocity in the community.

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(‒)-Cannabidiol (CBD) is one of the major phytocannabinoids extracted from the genus. Its non-psychoactiveness and therapeutic potential, partly along with some anecdotal-if not scientific or clinical-evidence on the prevention and treatment of neurological diseases, have led researchers to investigate the biochemical actions of CBD on neural cells. This review summarizes the previously reported mechanistic studies of the CBD actions on primary neural cells at the in vitro cell-culture level.

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  • Physical exercise has been shown to reduce drug use in addicted individuals during various phases of addiction, but little is known about the neurobiological effects of exercise.
  • This study focused on how moderate endurance exercise affects methamphetamine (METH) behavior and neurobiology in male rats, specifically looking at changes in dopamine levels and various signaling molecules.
  • Results indicated that endurance exercise reduced METH-induced hyperactivity and altered the expression of certain proteins in the brain, suggesting exercise may inhibit METH effects through changes in glutamate signaling in the striatum.*
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Objectives: The education and school life of children who have undergone cochlear implantation (CI) is very important and should be monitored continuously. This study assessed auditory performance in children with cochlear implants over time, along with educational placement and peer relationship, and compared the results based on the age at CI and the presence of additional disabilities.

Design: In total, 77 children who had undergone CI at the Hearing Center in Ajou University Hospital at less than 10 years old and who were presently attending school or had already graduated from school within 3 years were enrolled in this study.

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The present study investigated the chemical composition, antioxidant, antimicrobial, and anti-inflammatory activities of essential oil (EO) derived from the wild rhizomes of Atractylodes macrocephala Koidz. (AMA) growing in Qimen County (eastern China). GC/MS analysis identified fifteen compounds, representing 92.

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Objectives: This study evaluated the influence of the performance of the first cochlear implant (CI-1) on the second implant (CI-2) and the significance of inter-implant intervals in children with sequential cochlear implantation.

Method: Thirty-four patients were included for speech perception outcome and 38 patients were included for subjective hearing satisfaction in daily life in this study. The patients were classified into 3 groups according to inter-implant interval: group I, <4 years; group II, 4-7 years; group III, >7 years.

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Mulberry ( L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects.

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[Purpose] To analyze the electromyographic (EMG) activities of several lower extremity muscles during ground walking and pedaling using the Pedalo Reha-Bar device. [Subjects and Methods] Fifteen healthy adults aged 20-29 year participated in this study. The subjects' surface EMG signals while walking and Pedalo Reha-Bar riding were recorded.

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Background: The interleukin 10 deficient mice (IL-10(-/-)) showed high incidence of pup alopecia compared to other strains, and pup alopecia was caused by skin inflammation and was recoverable. Pup alopecia of B6.IL-10(-/-) might be related with maternal factor and interleukin-10 deficient phenotype.

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A simple separation and detection system based on an electrochemical potential modulated microchannel (EPMM) device was developed for the first time. The application of alternating current (AC) potential to the microfluidic separation channel walls, which were composed of screen printed carbon electrodes, resulted in the oscillation and fluctuation of analytes and in the formation of a perfect flat flow front. These events resulted in an increase in the effective concentration and in the fine separation of samples.

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Aneurysm of the mitral valve, although uncommon, occurs most commonly in association with infective endocarditis of the aortic valve and true mitral valve aneurysm is a rare cause of mitral regurgitation. We report a case with perforated mitral valve aneurysm in the posterior leaflet without concurrent infective endocarditis initially mistaken diagnosis of cystic mass, which was confirmed at operation with successful mitral valve annuloplasty.

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Catalytic dehydropolymerization and subsequent silane-capping with R2SiHCI (R = Ph, Me) of 1,1-dihydrotetraphenylsilole (1) using various inorganic hydrides produces electroluminescent silane-capped polysiloles (2) in high yield. The polymerization yield and molecular weight increase in the order LiB[CH(CH3)C2H5]3H < NaB[CH(CH3)C2H5]3H < KB[CH(CH3)C2H5]3H. The molecular weights increase in the order Na[H2Al(OCH2CH2OCH3)2] < KB[CH(CH3)C2H5]3H < LiB(C2H5)3H.

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The dry sol-gel polycondensation at toluene in ambient air atmosphere of p-X-C6H4SiH3 (X = H, CH3, CH3O, F, Cl) to silica p-X-C6H4SiO15 in high yield, catalyzed by colloidal nickel nanoparticles in-situ generated from nickelocene(II), nickel(II) acetate, and bis(1,5-cyclooctadiene)nickel(0), is described. Similar catalytic activities were observed for the catalysts. Similarly, the dry sol-gel polyco-condensation p-X-C6H4SiH3 (X = CH3, CH3O, F, Cl):C6H4SiH3 (9:1 mole ratio) at toluene in ambient air atmosphere of was performed to yield co-silicas (p-X-C6H4SiO1.

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The combinative Si-Si/Si-O dehydrocoupling at ambient air atmosphere of 1,1-dihydrotetraphenylsilole 1 with 2 mol% of AgNO3 and Ag2SO4 in toluene at 90 degrees C produces optoelectronic polysiloles 2 in high yield. The complexes such as Cp2Co, Cp2Ni, Cp2ZrCl2/Red-Al, and AgCl were found to be ineffective for the dehydrocoupling of 1. The polysiloles mainly have Si-Si bonds along with the small portion of Si-O bonds in the polymer backbone chain.

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Similar outcomes have been reported for obese and nonobese patients after primary total hip arthroplasty (THA), indicating obesity is not a contraindication to total hip arthroplasty. However, obese patients may develop implant failure and require revision THA. We compared the outcomes of revision THA in a matched cohort of obese and nonobese patients.

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