A unified model for droplet receding contact angles on hydrophobic pillar, pore, and hollowed pillar arrays.

Hypothesis: Current models for receding contact angles of Cassie-Baxter state droplets on textured hydrophobic substrates are applicable only to a specific structural type, e.g., pillar (above which a droplet has isolated contact line and continuous liquid-vapor interface) or pore (continuous contact line and isolated liquid-vapor interface), signifying a lack of universality.

Sticky Superhydrophobic State.

It is common sense that the droplet is stickier to substrates with larger solid-liquid contact areas. Here, we report that this intuitive trend reverses for hollowed micropillars, where a decrease in solid-liquid contact area caused by an increase in the pore size of a pillar top leads to an increase in the droplet depinning force. As compared to relief of liquid-vapor interface distortion caused by the sliding of the contact line on filled pillars, the pore hinders the contact line sliding, hence leading to enhanced interface distortion and droplet adhesion.

Safety and feasibility of neoadjuvant chemoradiotherapy combined with immunotherapy for locally advanced esophageal squamous cell carcinoma: a prospective single-group phase II clinical study.

Background: Neoadjuvant chemoradiotherapy (nCRT) combined with surgery is still the standard treatment mode for esophageal cancer (EC), but the rate of distant metastasis and local recurrence of this triple mode is still high. Distant metastasis is the main recurrence pattern. Therefore, there is an urgent need to explore a new treatment model to improve pathologic complete response (pCR) and patient survival.

Radiotherapy for patients with locally advanced esophageal squamous cell carcinoma receiving neoadjuvant immunotherapy combined with chemotherapy.

With the success of immunotherapy in advanced esophageal cancer, neoadjuvant chemo-immunotherapy (CIT) is being increasingly used for local staged esophageal cancer, especially in the context of clinical trials, which brings similar pCR with neoadjuvant chemoradiotherapy and shows promising results. However, there is still a part of potentially operable patients can't undergo surgery after neoadjuvant chemo-immunotherapy. The follow-up treatment and prognosis of this population remain unclear.

Soft wetting: an analytical model for pillar topography- and softness-dependent droplet depinning force.

The extent to which a droplet pins on a textured substrate is determined by the dynamics of the contact line and the liquid-vapor interface. However, the synergistic contribution of contact line sliding and interface distortion to the droplet depinning force remains unknown. More strikingly, current models fail to predict the depinning force per unit length of droplets on soft pillar arrays.

Three years follow-up of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer.

Neoadjuvant chemoimmunotherapy plays a crucial role in resectable non-small cell lung cancer (NSCLC). Neoadjuvant chemotherapy before sleeve lobectomy was safe and feasible, but the impact of neoadjuvant chemoimmunotherapy before sleeve lobectomy was unclear. In our retrospective study, patients diagnosed as stage IIB to IIIB resectable NSCLC between December 1, 2018 and December 1, 2020 in the Department of Thoracic Surgery, Zhejiang Cancer Hospital were collected.

Soft wetting: Substrate softness- and time-dependent droplet/bubble adhesion.

Hypothesis: The droplet/bubble adhesion characteristics depend on the length of the droplet/bubble three-phase contact line. Since the deformation caused by the liquid-gas interfacial tension on the soft substrate, referred as to the wetting ridge, retards contact line spreading and retraction, we conjecture that the droplet/bubble adhesion characteristics depend also on the substrate softness.

Experiments: Soft substrates with various shear moduli are prepared and characterized by the spreading and receding dynamics of water droplets and underwater bubbles.

A Superhydrophobicity-Slipperiness Switchable Surface with Magneto- and Thermo-responsive Wires for Repelling Complex Droplets.

The inefficacy of repelling water droplets laden with macromolecules (complex droplets or diluted polymer solution) is a long-standing shortcoming of superhydrophobic surfaces, which severely limits their reliability in practical applications. Here, we design a surface termed the superhydrophobicity-slipperiness switchable surface (3S surface), which demonstrates superhydrophobicity at room temperature and slipperiness when heated. The 3S surface is composed of magneto-responsive wires coated with superhydrophobic nanoparticles and impregnated with thermoresponsive paraffin, exhibiting lotus leaf-inspired passive water repellency and respiratory cilia-inspired active water repellency at room temperature.

Soft Wetting: Droplet Receding Contact Angles on Soft Superhydrophobic Surfaces.

Despite intensive investigations on the droplet receding contact angle on superhydrophobic surfaces, i.e., a key parameter characterizing surface wettability and adhesion, the quantitative correlation between the surface structure mechanical properties (softness) and the droplet receding contact angles remains vague.

Dynamic and Quasi-static Droplet Penetration through Meshes.

We investigate experimentally the effects of pore size, surface wettability, and penetration mode on the characteristics of liquid penetration through meshes. Utilizing the impact of droplets and the hydrostatic pressure, we study water penetration through superhydrophobic, hydrophobic, superhydrophilic, and hydrophilic meshes with different uniform radii and pitch values of the pores. In the case of dynamic penetration enabled by the droplet impact, our results show that surface wettability has a negligible effect on either the threshold speed of the droplet penetration or the penetrating liquid mass.

Genomic and Transcriptomic Remodeling by Neoadjuvant Chemoradiotherapy (nCRT) and the Indicative Role of Acquired INDEL Percentage for nCRT Efficacy in Esophageal Squamous Cell Carcinoma.

Purpose: The effect of genomic factors on the response of patients with esophageal squamous cell carcinoma (ESCC) to neoadjuvant chemoradiotherapy (nCRT), as well as how nCRT influences the genome and transcriptome of ESCC, remain largely unknown.

Methods And Materials: In total, 137 samples from 57 patients with ESCC undergoing nCRT were collected and subjected to whole-exome sequencing and RNA sequencing analysis. Genetic and clinicopathologic factors were compared between the patients achieving pathologic complete response and patients not achieving pathologic complete response.

Bioinspired Wire-on-Pillar Magneto-Responsive Superhydrophobic Arrays.

Versatile surfaces demonstrating multiple interfacial functionalities are highly demanded as a surface typically serves various duties and faces multiple challenges in real practice. However, such versatile surfaces are rarely reported mainly due to the challenges in integrating multiple structural characteristics. Here, by mimicking lotus leaves, butterfly wing, and respiratory cilia, we develop a surface termed wire-on-pillar magneto-responsive superhydrophobic arrays (WP-MRSA), which possess interfacial properties of structural superhydrophobicity, anisotropicity, stimuli responsiveness, and flexibility.

The control of dry-out patterns using bubble-containing droplets.

Hypothesis: For an evaporating nanofluid droplet that contains a bubble inside, we suspect the bubble boundary remains pinned during evaporation whereas the droplet perimeter recedes. Thus, the dry-out patterns are mainly determined by the presence of the bubble and their morphology can be tuned by the size and location of the added bubble.

Experiments: Bubbles with varying base diameters and lifetimes are added into evaporating droplets that contain nanoparticles with different types, sizes, concentrations, shapes, and wettability.

Surgical selection and regional lymph node dissection for stage I second primary lung cancer patients following surgery for stage I first primary lung cancer.

Introduction: Studies investigating surgery for second primary non-small cell lung cancer (SP) patients are rare. The aim of this study was to explore the effects of surgical methods and regional lymph node (LN) dissection on lung cancer-specific mortality (LCSM) in stage I SP patients following surgery for stage I first primary non-small cell lung cancer (FP).

Methods: Data on patients diagnosed with stage I SP after surgery for stage I FP were extracted from the Surveillance, Epidemiology, and End Results (SEER) database.

A combined predictive model based on radiomics features and clinical factors for disease progression in early-stage non-small cell lung cancer treated with stereotactic ablative radiotherapy.

Purpose: To accurately assess disease progression after Stereotactic Ablative Radiotherapy (SABR) of early-stage Non-Small Cell Lung Cancer (NSCLC), a combined predictive model based on pre-treatment CT radiomics features and clinical factors was established.

Methods: This study retrospectively analyzed the data of 96 patients with early-stage NSCLC treated with SABR. Clinical factors included general information (e.

Droplet Spreading and Adhesion on Spherical Surfaces.

Adhesion of a liquid droplet to a solid surface is a result of solid surface interactions with surrounding fluids, affected by its wettability and morphology. Unfortunately, the direct measurements of adhesion forces are rarely reported in the scientific literature, especially for solids with curvatures. In this study, by using a high-sensitivity microelectronic mechanical balance which vertically deposits and then pulls liquid droplets, the spreading and adhesion forces for water and ethylene glycol droplets on spherical surfaces of polyethylene terephthalate (PET) with radii of curvature from 2 to 8 mm were recorded.

Detection of internal humidity in a transformer via optical interferometry.

To detect the internal humidity of the transformer accurately and sensitively and eliminate the interference caused by electromagnetic fields, an interferometric measurement is proposed in this paper for the first time, to the best of our knowledge. The phase value distribution of the interferogram affected by humidity can be extracted quantitatively. The peak-to-peak value (P-P) of the phase image can reflect the humidity, according to theoretical analysis, and the main factors affecting the P-P are current and humidity.

Crosstalk between the gut microbiome and clinical response in locally advanced thoracic esophageal squamous cell carcinoma during neoadjuvant camrelizumab and chemotherapy.

Background: The gut microbiome is associated with the response to immunotherapy in a variety of advanced cancers. However, the influence of the gut microbiome on locally advanced esophageal squamous cell carcinoma (ESCC) during programmed cell death protein 1 (PD-1) antibody immunotherapy plus chemotherapy is not clearly demonstrated. To explore the crosstalk between the gut microbiome and clinical response in locally advanced thoracic ESCC during neoadjuvant camrelizumab and chemotherapy.

Maximum Spreading of Impacting Ferrofluid Droplets under the Effect of Nonuniform Magnetic Field.

This article investigates the maximum spreading of ferrofluid droplets impacting on a hydrophobic surface under nonuniform magnetic fields. A generalized model for scaling the maximum spreading is developed. It is observed that, if the magnetic field strength is zero, a ferrofluid droplet not only demonstrates similar spreading dynamics as the water droplet but also obeys the same scaling law for the maximum spreading factor.

Long non-coding RNA MCM3AP antisense RNA 1 promotes non-small cell lung cancer progression through targeting microRNA-195-5p.

Lung cancer (LC) ranks first among all causes of cancer-related death, with non-small cell lung cancer (NSCLC) taking up 85% of lung cancer cases. Although lncRNA MCM3AP antisense RNA 1 (MCM3AP-AS1) has been reported to be an oncogenic factor in NSCLC, its detailed mechanism in NSCLC is unknown. In this study, quantitative real-time polymerase chain reaction (qRT-PCR) was performed to determine MCM3AP-AS1, microRNA (miR)-195-5p and E2F transcription factor 3 (E2F3) mRNA expressions in NSCLC tissues and cells.

The safety and efficacy of neoadjuvant programmed death 1 inhibitor therapy with surgical resection in stage IIIA non-small cell lung cancer.

Background: Lung cancer ranks as the most prevalent solid cancer in the world. The non-small-cell lung cancer (NSCLC) histological subtype accounts for the largest proportion of lung cancers. Even though neoadjuvant therapy has shown encouraging efficacy for resectable NSCLC, there is a lack of clinical data on the treatment of stage IIIA NSCLC patients.

Neoadjuvant pembrolizumab with chemotherapy for the treatment of stage IIB-IIIB resectable lung squamous cell carcinoma.

Background: Researches on programmed cell death (PD-1) as neoadjuvant immunotherapy for resectable non-small cell lung cancer is underway, which brings hope for individuals with the disease. However, a study dedicated to lung squamous cell carcinoma (LUSC) specifically has yet to be conducted. Now, data from our pilot prospective research neoadjuvant study provide new insights in the field of neoadjuvant regimen for LUSC.

The safety and efficacy of neoadjuvant PD-1 inhibitor with chemotherapy for locally advanced esophageal squamous cell carcinoma.

Background: Neoadjuvant therapy followed by esophagectomy has been recognized as an effective treatment for locally advanced esophageal cancer, though still has a dismal prognosis. Antibodies against programmed death 1 (PD-1) protein improve survival in patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC) compared with chemotherapy in second-line therapy. However, neoadjuvant PD-1 inhibitor combined with chemotherapy has not been tested in locally advanced ESCC.

Neoadjuvant immunotherapy for elderly patients with non-small-cell lung cancer: a case report and literature review.

Although neoadjuvant immunotherapy has achieved remarkable results in the treatment of lung cancer, it is still infrequently applied in geriatric patients. We report on a 76-year-old male patient with a long-term history of heavy smoking presenting with cough and hemolysis. There was no related underlying disease or positive findings on physical examination.

Droplet Characteristics at the Maximum Adhesion on Curved Surfaces.

For applications involving droplet detachment from solid surfaces, it is vital to study the droplet characteristics (e.g., contact angle and base width) when the droplet is experiencing the maximum force that detaches the droplet (maximum adhesion state).