Publications by authors named "Youheng Jiang"
Article Synopsis
- Grem1 cancer-associated fibroblasts (CAFs) play a vital role in the development of colorectal cancer (CRC), but their origins and functions have been difficult to study due to technical limitations.
- * The research used an optimized gut Swiss-roll technique to create single cryopreserved slides, revealing a significant increase in Grem1 CAFs in tumor tissues compared to normal mucosa at 12 weeks.
- * Lineage tracing showed that most Grem1 CAFs in the tumor core derived from Grem1 intestinal reticular stem cells (iRSCs), indicating their potential as a key target for early CRC therapies, while a smaller subset came from Grem1 intestinal sub-epithelial myofibroblasts
Article Synopsis
- The gut-brain axis plays a role in neuropsychiatric diseases like autism spectrum disorder (ASD), and the study focuses on the genetic variation 16p11.2 linked to ASD.
- Using a mouse model with the 16p11.2 duplication, researchers found that these mice exhibited ASD-like behaviors and structural changes in their gut microbiota, indicating dysbiosis and reduced biodiversity.
- Metabolomic analysis revealed 19 altered metabolites and disruptions in neurotransmitter pathways, particularly those involving histamine, suggesting connections between gut microbiota and ASD that could inform future treatments.
Article Synopsis
- Microdeletions in the 16p11.2 chromosomal region are linked to autism spectrum disorder (ASD) and other neurodevelopmental issues, with unclear mechanisms and no effective treatments available.
- The study found that mice with 16p11.2 showed altered gut microbiota and low levels of the microbial metabolite indole-3-propionic acid (IPA), leading to social and cognitive deficits as well as changes in brain neuron activity.
- Administering IPA improved behavior and brain function in these mice and increased phosphorylation of the protein ERK1, suggesting gut microbial metabolites play a significant role in the effects of 16p11.2 and could be a potential treatment for ASD.
Isocitrate dehydrogenase (IDH) mutation, a known pathologic classifier, initiates metabolic reprogramming in glioma cells and has been linked to the reaction status of glioma-associated microglia/macrophages (GAMs). However, it remains unclear how IDH genotypes contribute to GAM phenotypes. Here, it is demonstrated that gliomas expressing mutant IDH determine M1-like polarization of GAMs, while archetypal IDH induces M2-like polarization.
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- Aberrant expression of GPR158 is linked to various central nervous system diseases, but its role is unclear due to insufficient biological understanding and tools.
- Researchers created a mouse model with tagged GPR158, which showed no behavioral abnormalities and was predominantly expressed in neurons, specifically enriched in certain types of neurons within key brain regions.
- The study identified potential interacting proteins and explored their roles in synaptic function, suggesting that this mouse model can help clarify GPR158's biological and pharmacological significance.
Cancer cell survival, function and fate strongly depend on endoplasmic reticulum (ER) proteostasis. Although previous studies have implicated the ER stress signaling network in all stages of cancer development, its role in cancer metastasis remains to be elucidated. In this study, we investigated the role of Gremlin-1 (GREM1), a secreted protein, in the invasion and metastasis of colorectal cancer (CRC) cells in vitro and in vivo.
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