Study of the image motion compensation method for a vertical orbit dynamic scanning TDICCD space camera.

In this study, a collaborative compensation method for low-dimensional attitude maneuvering and time delay integration charge-coupled device (TDICCD) line-frequency matching is proposed. The method is combined with the validation and analysis of the coordinate system transformation model to address the mismatch between the TDI charge transfer speed and the speed of the target. This mismatch is caused by the inconsistency between the rotational scanning direction of the double-sided mirror used for dynamic vertical orbit scanning imaging in low Earth-orbit satellites and the direction of the satellite along its orbit.

Effects of polyol excipient stability during storage and use on the quality of biopharmaceutical formulations.

Biopharmaceuticals are formulated using a variety of excipients to maintain their storage stability. However, some excipients are prone to degradation during repeated use and/or improper storage, and the impurities generated by their degradation are easily overlooked by end users and are usually not strictly monitored, affecting the stability of biopharmaceuticals. In this study, we evaluated the degradation profile of polyol excipient glycerol during repeated use and improper storage and identified an unprecedented cyclic ketal impurity using gas chromatography with mass spectrometry (GC-MS).

Identification and characterization of chemical and physical stability of insulin formulations utilizing degraded glycerol after repeated use and storage.

Insulin treatment is currently considered to be the main strategy for controlling diabetes. Although the recombinant insulin formulation is relatively mature, we found that a batch of insulin formulation exhibited an unusual degradation rate in the stability experiment. The main purposes of this article are to identify the root cause for this phenomenon and characterize of chemical and physical degradation products.

Geographical spread of SARS in mainland China.

Objectives: To describe the spatiotemporal diffusion of the severe acute respiratory syndrome (SARS) epidemic in mainland China, and to analyse the spatial pattern of SARS transmission from the Beijing epicentre to its neighbouring areas.

Methods: Probable SARS cases occurring between November 2002 and May 2003 in mainland China were compiled from different sources and geo-coded into a geographical information database based on onset location. Spatial analyses including kernel density estimation, and spatial statistical and tracking analyses were performed to characterise the spatiotemporal distribution of SARS cases based on onset location/date.

Predicting the risk of hantavirus infection in Beijing, People's Republic of China.

To understand the spatial distribution of hantavirus infections across landscapes and its influencing environment factors in Beijing, People's Republic of China, rodents captured in this region were examined for hantavirus by reverse transcription-polymerase chain reaction. A total of 1,639 rodents were trapped at 86 randomly selected sites. The overall infection rate for hantavirus was 7.

Spatial analysis of malaria in Anhui province, China.

Background: Malaria has re-emerged in Anhui Province, China, and this province was the most seriously affected by malaria during 2005-2006. It is necessary to understand the spatial distribution of malaria cases and to identify highly endemic areas for future public health planning and resource allocation in Anhui Province.

Methods: The annual average incidence at the county level was calculated using malaria cases reported between 2000 and 2006 in Anhui Province.