Continuous live imaging reveals a subtle pathological alteration with cell behaviors in congenital heart malformation.

To form fully functional four-chambered structure, mammalian heart development undergoes a transient finger-shaped trabeculae, crucial for efficient contraction and exchange for gas and nutrient. Although its developmental origin and direct relevance to congenital heart disease has been studied extensively, the time-resolved cellular mechanism underlying hypotrabeculation remains elusive. Here, we employed live imaging and reconstructed the holistic cell lineages and cellular behavior landscape of control and hypotrabeculed hearts of mouse embryos from E9.

Prediction of Surface Roughness of Abrasive Belt Grinding of Superalloy Material Based on RLSOM-RBF.

It is difficult to accurately predict the surface roughness of belt grinding with superalloy materials due to the uneven material distribution and complex material processing. In this paper, a radial basis neural network is proposed to predict surface roughness. Firstly, the grinding system of the superalloy belt is introduced.

A Multiscale Interactive Recurrent Network for Time-Series Forecasting.

Time-series forecasting is a key component in the automation and optimization of intelligent applications. It is not a trivial task, as there are various short-term and/or long-term temporal dependencies. Multiscale modeling has been considered as a promising strategy to solve this problem.

The evaluation of the desensitization effect of a desensitizing agent and desensitizing toothpastes in vitro.

This study was evaluating how three desensitizing toothpastes used at home influence the effect associated with desensitizing agents after application in the clinic. Fifty dentine disks measure it permeability and 32 dentine disks with similar permeability levels were selected. Following Dental desensitizer treatment, dentine disks were randomly divided into three subgroups (n=10) that received applications of three toothpastes, respectively.

Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution.

Mapping of the holistic cell behaviours sculpting the four-chambered mammalian heart has been a goal or previous studies, but so far only success in transparent invertebrates and lower vertebrates with two-chambered hearts has been achieved. Using a live-imaging system comprising a customized vertical light-sheet microscope equipped with a mouse embryo culture module, a heartbeat-gated imaging strategy and a digital image processing framework, we realized volumetric imaging of developing mouse hearts at single-cell resolution and with uninterrupted cell lineages for up to 1.5 d.

Comparison of technical, biological, and esthetic parameters of ceramic and metal-ceramic implant-supported fixed dental prostheses: A systematic review and meta-analysis.

Statement Of Problem: Differences between ceramic and metal-ceramic implant-supported fixed dental prostheses are unclear.

Purpose: The purpose of this systematic review and meta-analysis was to compare the technical, biological, and esthetic complication rates of implant-supported ceramic and metal-ceramic restorations.

Material And Methods: Six databases were searched to identify randomized controlled clinical trials (RCTs) and prospective and retrospective cohort studies of implant-supported fixed dental prostheses.

Network meta-analysis of the desensitizing effects of lasers in patients with dentine hypersensitivity.

Objectives: This network meta-analysis compares different lasers, placebo, and no treatment in terms of their effects on dentine hypersensitivity (DH) immediately after treatment and over the long term (1 month).

Methods: A systematic electronic literature search of four databases and a manual search were performed to identify randomized controlled trials (RCTs) examining different laser treatments for the treatment of DH. Pairwise and network meta-analyses were performed to analyze the desensitization effect immediately after treatment and over the long term.

Effect of Lasers on Dentine Hypersensitivity: Evidence From a Meta-analysis.

Objectives: The aim of the study was to evaluate the immediate and long-term desensitizing effect of lasers in reducing dentine hypersensitivity (DH) compared with negative controls.

Material And Methods: Six databases were searched to identify relevant articles published up to June 8, 2018. Randomized controlled trials comparing lasers with placebo or no treatment control in adult patients who suffer from DH were included.

Network meta-analysis on the effect of desensitizing toothpastes on dentine hypersensitivity.

Objectives: This network meta-analysis compares different desensitizing toothpastes and placebo in terms of their effects on dentine hypersensitivity (DH) at 2, 4, and 8 weeks.

Materials And Methods: A systematic electronic literature search of four databases, and a manual search, were performed to identify randomized controlled trials (RCTs) on different desensitizing toothpastes for the treatment of DH. Pair-wise and network meta-analyses were performed to analyze the desensitization effect at 2, 4, and 8 weeks.

Effect of desensitizing toothpastes on dentine hypersensitivity: A systematic review and meta-analysis.

Objectives: To evaluate the desensitizing effect of toothpastes that contain ingredients that act against dentine hypersensitivity (DH) and to compare this effect with negative controls.

Sources: Five databases were searched to identify relevant articles published up to November 27, 2017.

Study Selection: Randomized controlled trials (RCTs) comparing desensitizing toothpastes with a toothpastes without desensitizing component in adult patients that suffer from DH were included.

(K,Na)NbO3 nanofiber-based self-powered sensors for accurate detection of dynamic strain.

A self-powered active strain sensor based on well-aligned (K,Na)NbO3 piezoelectric nanofibers is successfully fabricated through the electrospinning and polymer packaging process. The device exhibits a fast, active response to dynamic strain by generating impulsive voltage signal that is dependent on the amplitude of the dynamic strains and the vibration frequency. When the frequency is fixed at 1 Hz, the peak to peak value of the voltage increases from ∼1 to ∼40 mV, and the strain changes from 1 to 6%.