Publications by authors named "Youdong Liu"
Background: Maintaining iron homeostasis is crucial for preventing the development of colorectal cancer (CRC). However, Evidence regarding the correlation between serum iron status and CRC has been inconsistent. This population-based study aims to explore the potential association between serum iron status and CRC risk.
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- Intercellular communication between colon cancer (CC) cells and colonic epithelial cells (CECs) is not well understood, but it plays a crucial role in CC progression.
- The study finds that intact mitochondrial DNA (mtDNA) is present in serum extracellular vesicles (EVs) from CC patients and correlates with higher tumor stages.
- EV-mtDNA enhances mitochondrial functions and TGFβ1 expression in CECs, promoting tumor progression through mechanisms involving reactive oxygen species (ROS) and the TGFβ/Smad pathway, suggesting it could be a valuable biomarker or therapeutic target for CC.
Article Synopsis
- Metastasis significantly contributes to deaths in colorectal cancer (CRC), with tumor-associated macrophages (TAMs) playing a crucial regulatory role in this process.
- Research methods included immunohistochemistry to assess TAM infiltration, assays to study tumor cell migration, and advanced techniques like RNA sequencing to identify key genetic changes in CRC cells influenced by TAMs.
- Findings suggest that TAM-derived extracellular vesicles (EVs) can enhance the motility of CRC cells by increasing cholesterol efflux and altering membrane fluidity through a specific molecular pathway, highlighting DOCK7 as a potential target for CRC metastasis treatment.
Article Synopsis
- - Evidence shows that cytokines are found in tumor-derived extracellular vesicles (EVs) and play a significant role in the development of various cancers, including colorectal cancer (CRC).
- - The study identified that TNF-α levels are higher in EVs from CRC patients and cell lines, and this increase is linked to aggressive cancer features; its secretion relies on a protein called SNAP23.
- - TNF-α from EVs promotes CRC cell metastasis through a pathway involving SNAP23, impacting other signaling pathways and suggesting that the TNF-α/SNAP23 interaction could be useful as a diagnostic marker and treatment target for CRC.
The activity of integrin-linked kinase (ILK) in cancerous cells is often oncogenic and associated with malignant properties, such as uncontrolled cell cycle progression and evasion from senescence. However, the role of ILK in cellular senescence in gastric cancer (GC) has not been previously examined. We generated single-cell clones of ILK knock-out using CRISPR-Cas9 in human GC lines with mesenchymal or epithelial histology.
View Article and Find Full Text PDFDespite dramatic responses to immune checkpoint inhibitors (ICIs) in patients with colon cancer (CC) harboring deficient mismatch repair (dMMR), more than half of these patients ultimately progress and experience primary or secondary drug resistance. There is no useful biomarker that is currently validated to accurately predict this resistance or stratify patients who may benefit from ICI-based immunotherapy. As hypoxic and acidic tumor microenvironment would greatly impair tumor-suppressing functions of tumor-infiltrating lymphocytes (TILs), we sought to explore distinct immunological phenotypes by analysis of the intratumoral hypoxia state using a well-established gene signature.
View Article and Find Full Text PDFThe EMT (epithelial-to-mesenchymal-transition) subtype of gastric cancer (GC) is associated with poor treatment responses and unfavorable clinical outcomes. Despite the broad physiological roles of the micro-RNA (miR)-200 family, they largely serve to maintain the overall epithelial phenotype. However, during late-stage gastric tumorigenesis, members of the miR-200 family are markedly suppressed, resulting in the transition to the mesenchymal state and the acquisition of invasive properties.
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