CCL24 Protects Renal Function by Controlling Inflammation in Podocytes.

Diabetic nephropathy (DN) is one of the most lethal complications of diabetes mellitus with chronic inflammation. We have examined the role of the inflammatory chemokine CCL24 in DN. We observed that serum levels of CCL24 were significantly elevated in patients with DN.

TM7SF1, an important autophagy regulatory protein in mouse podocytes.

The autophagy, which can be regulated by lysosomal membrane proteins, plays a critical role in maintaining normal podocyte function. TM7SF1 is a novel lysosomal membrane protein, but its effect on autophagy is still unknown. This study aimed to identify the role of TM7SF1 in mouse podocyte (MPC5) autophagy.

Axial Impact Load of a Concrete-Filled Steel Tubular Member with Axial Compression Considering the Creep Effect.

The dynamic loads acting on concrete-filled steel tubular members under axial impacts by rigid bodies were studied herein by FEM. The whole impact process was simulated and the time history of the impact load was obtained. The effects of eight factors on the axial impact load were studied; these factors were the impact speed, mass ratio, axial pressure ratio, steel ratio, slenderness ratio, concrete strength, impact position, and boundary conditions.

Cytotoxic and Antitumor Effects of Curzerene from Curcuma longa.

Curzerene is a sesquiterpene and component used in oriental medicine. It was originally isolated from the traditional Chinese herbal medicine rhizomes. In this study, anticancer activity of curzerene was examined in both and models.