Multi‑omics identification of a signature based on malignant cell-associated ligand-receptor genes for lung adenocarcinoma.

Purpose: Lung adenocarcinoma (LUAD) significantly contributes to cancer-related mortality worldwide. The heterogeneity of the tumor immune microenvironment in LUAD results in varied prognoses and responses to immunotherapy among patients. Consequently, a clinical stratification algorithm is necessary and inevitable to effectively differentiate molecular features and tumor microenvironments, facilitating personalized treatment approaches.

Comprehensive pan-cancer analysis reveals EPHB2 is a novel predictive biomarker for prognosis and immunotherapy response.

Purpose: Recent studies have increasingly linked Ephrin receptor B2 (EPHB2) to cancer progression. However, comprehensive investigations into the immunological roles and prognostic significance of EPHB2 across various cancers remain lacking.

Methods: We employed various databases and bioinformatics tools to investigate the impact of EPHB2 on prognosis, immune infiltration, genome instability, and response to immunotherapy.

Self-Sustaining Triboelectric Nanosensors for Real-Time Urine Analysis in Smart Toilets.

Healthcare has undergone a revolutionary shift with the advent of smart technologies, and smart toilets (STs) are among the innovative inventions offering non-invasive continuous health monitoring. The present technical challenges toward this development include limited sensitivity of integrated sensors, poor stability, slow response and the requirement external energy supply alongside manual sample collection. In this article, triboelectric nanosensor array (TENSA) is introduced featuring electrodes crafted from laser-induced 3D graphene with functional polymers like polystyrene, polyimide, and polycaprolactone for real-time urine analysis while generating 50 volts output via urine droplet-based triboelectrification.

Contact-electro-catalytic CO reduction from ambient air.

Traditional catalytic techniques often encounter obstacles in the search for sustainable solutions for converting CO into value-added products because of their high energy consumption and expensive catalysts. Here, we introduce a contact-electro-catalysis approach for CO reduction reaction, achieving a CO Faradaic efficiency of 96.24%.

Longer Photoperiod Substantially Increases Indoor-Grown Cannabis' Yield and Quality: A Study of Two High-THC Cultivars Grown under 12 h vs. 13 h Days.

Indoor-grown is commonly transitioned to a 12 h daily photoperiod to promote flowering. However, our previous research has shown that some indoor-grown cannabis cultivars can initiate strong flowering responses under daily photoperiods longer than 12 h. Since longer photoperiods inherently provide higher daily light integrals (DLIs), they may also increase growth and yield.

Facile Graphene Oxide Modification Method via Hydroxyl-yne Click Reaction for Ultrasensitive and Ultrawide Monitoring Pressure Sensors.

Enhancing the durability and functionality of existing materials through sustainable pathways and appropriate structural design represents a time- and cost-effective strategy for the development of advanced wearable devices. Herein, a facile graphene oxide (GO) modification method via the hydroxyl-yne click reaction is present for the first time. By the click coupling between propiolate esters and hydroxyl groups on GO under mild conditions, various functional molecules are successfully grafted onto the GO.

Magic Blue Light: A Versatile Mediator of Plant Elongation.

Blue light plays an important role in regulating plant elongation. However, due to the limitations of older lighting technologies, the responses of plants to pure blue light have not been fully studied, and some of our understandings of the functions of blue light in the literature need to be revisited. This review consolidates and analyzes the diverse findings from previous studies on blue-light-mediated plant elongation.

Biodegradable, Biocompatible, and Implantable Multifunctional Sensing Platform for Cardiac Monitoring.

Cardiac monitoring after heart surgeries is crucial for health maintenance and detecting postoperative complications early. However, current methods like rigid implants have limitations, as they require performing second complex surgeries for removal, increasing infection and inflammation risks, thus prompting research for improved sensing monitoring technologies. Herein, we introduce a nanosensor platform that is biodegradable, biocompatible, and integrated with multifunctions, suitable for use as implants for cardiac monitoring.

Self-powered freestanding multifunctional microneedle-based extended gate device for personalized health monitoring.

Online monitoring of prognostic biomarkers is critically important when diagnosing disorders and assessing individuals' health, especially for chronic and infectious diseases. Despite this, current diagnosis techniques are time-consuming, labor-intensive, and performed offline. In this context, developing wearable devices for continuous measurements of multiple biomarkers from body fluids has considerable advantages including availability, rapidity, convenience, and minimal invasiveness over the conventional painful and time-consuming tools.

Protocol to fabricate wearable stretchable microneedle-based sensors.

Creating highly stretchable and robust electrodes while retaining conductivity and stability is challenging. Furthermore, combining these elastic parts with rigid ones brings its own problems due to the discrepancy in firmness between the flexible patches and rigid constructions. Here, we present a protocol to create a stable, conductive, and flexible microneedle sensor patch.

Is Twelve Hours Really the Optimum Photoperiod for Promoting Flowering in Indoor-Grown Cultivars of ?

("cannabis" hereafter) is a valuable recent addition to Canada's economy with the legalization for recreational use in 2018. The vast majority of indoor cannabis cultivators use a 12-h light/12-h dark photoperiod to promote flowering. To test the hypothesis that robust flowering initiation responses can be promoted in indoor-grown cannabis cultivars under longer photoperiods, clones of ten drug-type cannabis cultivars were grown under six photoperiod treatments.

Comprehensive analysis of 33 human cancers reveals clinical implications and immunotherapeutic value of the solute carrier family 35 member A2.

Background: Solute carrier family 35 member A2 (SLC35A2), which belongs to the SLC35 solute carrier family of human nucleoside sugar transporters, has shown regulatory roles in various tumors and neoplasms. However, the function of SLC35A2 across human cancers remains to be systematically assessed. Insights into the prediction ability of SLC35A2 in clinical practice and immunotherapy response remains limited.

Wearable Clinic: From Microneedle-Based Sensors to Next-Generation Healthcare Platforms.

The rapid development of wearable biosensing calls for next-generation devices that allow continuous, real-time, and painless monitoring of health status along with responsive medical treatment. Microneedles have exhibited great potential for the direct access of dermal interstitial fluid (ISF) in a minimally invasive manner. Recent studies of microneedle-based devices have evolved from conventional off-line detection to multiplexed, wireless, and integrated sensing.

Foliar Symptomology, Nutrient Content, Yield, and Secondary Metabolite Variability of Cannabis Grown Hydroponically with Different Single-Element Nutrient Deficiencies.

In controlled environment production systems, (hereafter cannabis) is a commodity with high nutrient demands due to prolific growth under optimized environmental conditions. Since nutrient deficiencies can reduce yield and quality, cultivators need tools to rapidly detect and evaluate deficiency symptoms so corrective actions can be taken quickly to minimize losses. We grew cannabis plants in solution culture with different individual nutrient elements withheld from the solutions to identify deficiency symptoms.

Toward Large-Scale Energy Harvesting by a UV-Curable Organic-Coating-Based Triboelectric Nanogenerator.

Triboelectric nanogenerators (TENGs) stand out as an attractive form of technology for the efficient harvest of mechanical energy and the powering of wearable devices due to their light weight, simplicity, high power density, and efficient vibration energy scavenging capabilities. However, the requirement for micro/nanostructures and/or complex and expensive instruments hinders their cheap mass production, thus limiting their practical applications. By using a simple, cost-effective, fast spray-coating process, we develop high-performance UV-curable triboelectric coatings for large-scale energy harvesting.

Ultra-Fast Portable and Wearable Sensing Design for Continuous and Wide-Spectrum Molecular Analysis and Diagnostics.

The design and characterization of spatiotemporal nano-/micro-structural arrangement that enable real-time and wide-spectrum molecular analysis is reported and demonestrated in new horizons of biomedical applications, such as wearable-spectrometry, ultra-fast and onsite biopsy-decision-making for intraoperative surgical oncology, chiral-drug identification, etc. The spatiotemporal sesning arrangement is achieved by scalable, binder-free, functionalized hybrid spin-sensitive (<↑| or <↓|) graphene-ink printed sensing layers on free-standing films made of porous, fibrous, and naturally helical cellulose networks in hierarchically stacked geometrical configuration (HSGC). The HSGC operates according to a time-space-resolved architecture that modulate the mass-transfer rate for separation, eluation and detection of each individual compound within a mixture of the like, hereby providing a mass spectrogram.

Indoor grown cannabis yield increased proportionally with light intensity, but ultraviolet radiation did not affect yield or cannabinoid content.

Cannabis () flourishes under high light intensities (LI); making it an expensive commodity to grow in controlled environments, despite its high market value. It is commonly believed that cannabis secondary metabolite levels may be enhanced both by increasing LI and exposure to ultraviolet radiation (UV). However, the sparse scientific evidence is insufficient to guide cultivators for optimizing their lighting protocols.

Control of triboelectrification on Al-metal surfaces through microstructural design.

The instantaneous discharge of accumulated static charge due to contact electrification can cause irreversible damage to electrostatic-sensitive systems. Despite major advances in reducing tribo-charges, the problem remains intractable. Here, four alumina microstructures are fabricated on aluminum (Al) by combining chemical etching and anodic oxidation, and the effects of surface composition and structure on the triboelectric performance are studied by assembling them with a polytetrafluoroethylene membrane into a solid-solid triboelectric nanogenerator.

Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring.

Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.

Quantifying Wetting Dynamics with Triboelectrification.

Wetting is often perceived as an intrinsic surface property of materials, but determining its evolution is complicated by its complex dependence on roughness across the scales. The Wenzel (W) state, where liquids have intimate contact with the rough surfaces, and the Cassie-Baxter (CB) state, where liquids sit onto air pockets formed between asperities, are only two states among the plethora of wetting behaviors. Furthermore, transitions from the CB to the Wenzel state dictate completely different surface performance, such as anti-contamination, anti-icing, drag reduction etc.

Artificially Intelligent Olfaction for Fast and Noninvasive Diagnosis of Bladder Cancer from Urine.

Globally, bladder cancer (BLC) is one of the most common cancers and has a high recurrence and mortality rate. Current clinical diagnostic approaches are either invasive or inaccurate. Here, we report on a cost-efficient, artificially intelligent chemiresistive sensor array made of polyaniline (PANI) derivatives that can noninvasively diagnose BLC at an early stage and maintain postoperative surveillance through ″smelling″ clinical urine samples at room temperature.

Bioinspired Triboelectric Nanosensors for Self-Powered Wearable Applications.

The sustainable operation of wearable sensors plays an important role in continuous and longtime health monitoring. Conventional batteries, which are bulky and rigid, do not satisfy these requirements and, rather, cause additional economic burdens and environmental problems by regular replacement of power sources. This article provides a review on an alternative solution in the form of self-powered devices that can harvest energy from the surrounding environment to support the operation of the wearable sensor.

A Wearable Microneedle-Based Extended Gate Transistor for Real-Time Detection of Sodium in Interstitial Fluids.

Sodium is a prominent prognostic biomarker for assessing health status, such as dysnatremia. As of now, detection and monitoring of sodium levels in the human body is carried out by means of laborious and bulky laboratory equipmentand/or by offline analysis of various body fluids. Herein, an innovative stretchable, skin-conformal and fast-response microneedle extended-gate FET biosensor is reported for real-time detection of sodium in interstitial fluids for minimally invasive health monitoring along with high sensitivity, low limit of detection, excellent biocompatibility, and on-body mechanical stability.