Radiofrequency ablation therapy for knee osteoarthritis: a systematic review and meta-analysis.

Objective: The objective of the study is to systematically analyze the safety and efficacy of radiofrequency ablation (RFA) therapy for the treatment of patients with knee osteoarthritis (KOA) and to assess the methodological quality of the published studies.

Methods: By searching the PubMed, Embase, and CENTRAL databases, we retrieved and collected relevant randomized controlled trials (RCTs) published up to June 26, 2023.

Results: We included 13 RCTs, involving a total of 865 patients.

Puerarin alleviates osteoporosis in rats by targeting the JAK2/STAT3 signaling pathway.

Osteoporosis (OP) is a common chronic progressive bone disease that increases fracture risk in postmenopausal women. Research suggests that puerarin (Pue) may be an effective treatment for OP. This study examined the effects and underlying mechanisms of Pue in treating postmenopausal osteoporosis (PMOP) in rats.

The Influence of Fused Deposition Modeling Parameters on the Properties of PA6/PA66 Composite Specimens by the Taguchi Method and Analysis of Variance.

Fused deposition modeling (FDM) is widely used in the rapid prototyping of polymers. Polyamide (PA) has excellent mechanical properties, but its application in FDM is limited due to its high water absorption, warpage, and forming shrinkage. The material of the filament and the printing parameters of the printer are two critical aspects that affect the performance of a component.

Distal clavicle fractures treated by anteroinferior plating with a single screw: Two case reports.

Background: For the treatment of distal clavicle fractures, each treatment method has its own advantages and disadvantages, and there is no optimal surgical solution.

Case Summary: Based on this, we report 2 cases of distal clavicle fractures treated utilizing an anterior inferior plate with a single screw placed in the distal, in anticipation of providing a better surgical approach to distal clavicle fracture treatment. Two patients were admitted to the hospital after trauma with a diagnosis of distal clavicle fracture, and were admitted to the hospital for internal fixation of clavicle fracture by incision and reduction, with good postoperative functional recovery.

Design, Synthesis, and Antiproliferative Activity of Selective Histone Deacetylases 6 Inhibitors Containing a Tetrahydropyridopyrimidine Scaffold.

The development of selective histone deacetylase 6 inhibitors (sHDAC6is) is being recognized as a therapeutic approach for cancers. In this paper, we designed a series of novel tetrahydropyridopyrimidine derivatives as sHDAC6 inhibitors. The most potent compound, 8-(2, 4-bis(3-methoxyphenyl)-5, 8-dihydropyrido [3, 4-]pyrimidin-7(6)-yl)--hydroxy-8-oxooctanamide (), inhibited HDAC6 with IC of 6.

Trapping Lithium Selenides with Evolving Heterogeneous Interfaces for High-Power Lithium-Ion Capacitors.

Transition metal selenides anodes with fast reaction kinetics and high theoretical specific capacity are expected to solve mismatched kinetics between cathode and anode in Li-ion capacitors. However, transition metal selenides face great challenges in the dissolution and shuttle problem of lithium selenides, which is the same as Li-Se batteries. Herein, inspired by the density functional theory calculations, heterogeneous can enhance the adsorption of Li Se relative to single component selenide electrodes, thus inhibiting the dissolution and shuttle effect of Li Se.

The influence of decreased salinity levels on the survival, growth and physiology of eelgrass Zostera marina.

Low salinity generally promotes the growth and propagation of temperate seagrasses, but the appropriate range is unclear. We subjected shoots of eelgrass Zostera marina to different salinity levels [10, 15, 20, 25, 30 PSU (control)] for 6 weeks under controlled laboratory conditions. We measured eelgrass responses in terms of survivorship, growth, productivity, leaf pigmentation and carbohydrate concentrations.

Carbon Dots-Regulated Pomegranate-Like Metal Oxide Composites: From Growth Mechanism to Lithium Storage.

Carbon dots (CDs) are considered as excellent structural regulator for metal oxides (MOs) due to their abundant functional groups, superior dispersibility, and ultrasmall size (<10 nm). Herein, a new approach is proposed to construct porous pomegranate-like MOs/CDs composite based on the CDs-induced in situ growth mechanism of ion adsorption-multipoint surface nucleation-crosslinking agglomeration. The proposed methodology is successfully applied to prepare SnO /CDs, Cu O/CDs, and Fe O /CDs composites, respectively, demonstrating its universality to metal oxides.

Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation.

Physalin B (PB), one of the major active steroidal constituents of Solanaceae Physalis plants, has a wide variety of biological activities. We found that PB significantly down-regulated β-amyloid (Aβ) secretion in N2a/APPsw cells. However, the underlying mechanisms are not well understood.

Construction of methylation-associated nomogram for predicting the recurrence-free survival risk of stage I-III lung adenocarcinoma.

The aim of our study was to investigate a methylation-associated predictor for prognosis in patients with stage I-III lung adenocarcinoma (LUAD). A DNA methylation-based signature was developed via univariate, least absolute shrinkage and selection operator and multivariate Cox regression models. We identified a 14-site methylation signature that was correlated with recurrence-free survival of stage I-III lung adenocarcinoma patients.

FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro.

Forkhead box O1 (FoxO1), a key molecule in the regulation of cell growth, differentiation and metabolism, is an important transcription factor. However, the effect of FoxO1 on Alzheimer's disease (AD) needs further investigation. In this study, we aimed to explore the function and mechanism of FoxO1 in amyloid-β (Aβ) production and tau phosphorylation in AD.

High Conversion of D-Fructose into D-Allulose by Enzymes Coupling with an ATP Regeneration System.

D-Allulose is a rare monosaccharide that exists in extremely small quantities in nature, and it is also hard to prepare at a large scale via chemical or enzyme synthetic route due to low conversion and downstream separation complexity. Using D-psicose epimerase and L-rhamnulose kinase, a method enabling high conversion of D-allulose from D-fructose without the need for a tedious isomer separation step was established recently. However, this method requires expensive ATP to facilitate the reaction.

Correction: Assimilable organic carbon (AOC) determination using GFP-tagged Pseudomonas fluorescens P-17 in water by flow cytometry.

[This corrects the article DOI: 10.1371/journal.pone.

Assimilable organic carbon (AOC) determination using GFP-tagged Pseudomonas fluorescens P-17 in water by flow cytometry.

One of the newly developed methods for Assimilable organic carbon (AOC) determination is leveraged on the cell enumeration by flow cytometry (FC) which could provide a rapid and automated solution for AOC measurement. However, cell samples staining with fluorescence dye is indispensable to reduce background and machine noise. This step would bring additional cost and time consuming for this method.

Self-assembly of nano/micro-structured Fe3O4 microspheres among 3D rGO/CNTs hierarchical networks with superior lithium storage performances.

Nano/micro-structured Fe3O4 microspheres among three-dimensional (3D) reduced graphene oxide (rGO)/carbon nanotubes (CNTs) hierarchical networks (the ternary composite is denoted as rGCFs) have been synthesized using a facile, self-assembled and one-pot hydrothermal approach. The rGCFs composite exhibits superior lithium storage performances: initial discharge and charge capacities of 1452 and 1036 mAh g(-1), respectively, remarkable rate capability at current densities from 100 mA g(-1) to 10 A g(-1) and outstanding cycling performance up to 200 cycles. The highly enhanced electrochemical performances of rGCFs depend heavily on the robust 3D rGO/CNTs hierarchical networks, the stable nano/microstructures of active Fe3O4 microspheres and the positive synergistic effects of building components.

High-sensitivity paracetamol sensor based on Pd/graphene oxide nanocomposite as an enhanced electrochemical sensing platform.

Well-dispersed Pd nanoparticles were facilely anchored on graphene oxide (Pd/GO) via a one-pot chemical reduction of the Pd(2+) precursor without any surfactants and templates. The morphology and composition of the Pd/GO nanocomposite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and energy dispersive analysis of X-ray (EDX). The stepwise fabrication process of the Pd/GO modified electrode and its electrochemical sensing performance towards paracetamol was evaluated using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and differential pulse voltammetry (DPV).

Designing of molecularly imprinted polymer-based potentiometric sensor for the determination of heparin.

A novel potentiometric sensor with high selectivity and sensitivity has been developed for the determination of heparin, based on the modification of heparin-imprinted polymer film onto a glassy carbon. The performance of the developed heparin sensor was evaluated, and the results indicated that a sensitive potentiometric sensor could be fabricated. The obtained heparin sensor shows high-selectivity monitoring of heparin, shorter response time (<4 min), wider linear range (0.