Evidences for the mechanism of Shenmai injection antagonizing doxorubicin-induced cardiotoxicity.

Background: Doxorubicin (DOX) is a widely used antitumor drug. However, its clinical application is limited for its serious cardiotoxicity. The mechanism of DOX-induced cardiotoxicity is attributed to the increasing of cell stress in cardiomyocytes, then following autophagic and apoptotic responses.

Sleep deprivation aggravates brain injury after experimental subarachnoid hemorrhage via TLR4-MyD88 pathway.

Subarachnoid hemorrhage (SAH) is a life-threatening cerebrovascular disease, and most of the SAH patients experience sleep deprivation during their hospital stay. It is well-known that sleep deprivation is one of the key components of developing several neurological disorders, but its effect on brain damage after SAH has not been determined. Therefore, this study was designed to evaluate the effect of sleep deprivation using an experimental SAH model in rats.

The aging properties and phase morphology of silica filled silicone rubber/butadiene rubber composites.

Large amounts of antioxidants are used in unsaturated rubber composites, such as butadiene rubber (BR), which would inevitably cause surface discoloration. In this study, silicone rubber (VMQ) was blended with BR for improving its anti-aging properties. It was found that VMQ/BR exhibits better thermal oxidative aging and ozone aging resistance than BR, especially for 20/80 VMQ/BR.

Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators.

Background: Doxorubicin (DOX) is a chemotherapy drug for malignant tumors. The clinical application of DOX is limited due to its dosage relative cardiotoxicity. Oxidative damage and cardiac inflammation appear to be involved in DOX-related cardiotoxicity.

[Effects of transforming growth factor-beta1 on rat cardiocyte hypertrophy].

Aim: To investigate the effects of transforming growth factor-beta1 (TGF-beta1) and signal protein Smad3 on rat myocardial hypertrophy.

Methods: The total protein was analysed by flow cytometer assay to judge the hypertrophy of myocardial cell incubated with different level of TGF-beta1 in cultured myocardial cells of neonatal rats. The models of rat cardiac hypertrophy were produced with constriction of the abdominal aorta.