New cadinane sesquiterpenoids from .

Chemical investigation of the aerial parts of led to the isolation of eight sesquiterpenoids and ten diterpenoids, including five cadinane sesquiterpenoids (-), three bisabolene sesquiterpenoids (), nine -kaurane diterpenoids (-), and an abietane diterpenoid (). Among them, are new and feature a rare lactone or furan ring derived from C-6 isopropyl group side chain. Compound was isolated from genus for the first time, and was also the first example of abietane-type diterpenoids from this plant.

Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole.

G-quadruplex nucleic acids are four-stranded DNA or RNA secondary structures that are formed in guanine-rich sequences. These structures exhibit extensive structural polymorphism and play a pivotal role in the control of a variety of cellular processes. To date, diverse approaches for high-throughput identification of G-quadruplex structures have been successfully developed, but high-throughput methods for further characterization of their topologies are still lacking.

[Preparation and release behaviour of mesoporous silica/ethylcellulose sustained-release mini-matrix].

Hot-melt extrusion was applied to prepare mesoporous silica/ethylcellulose mini-matrix for sustained release, and fenofibrate was used as a model drug, ethylcellulose and xanthan gum were chosen as sustained-release agent and releasing moderator, respectively. This novel matrix obtained the controlled release ability by combining mesoporous silica drug delivery system and hot-melt extrusion technology. And mesoporous silica particle (SBA-15) was chosen as drug carrier to increase the dissolution rate of fenofibrate in this martix.