Comparing simple and functional jejunal interposition with preserved duodenal passage after total gastrectomy.

Objective: This prospective randomized controlled trial aimed to compare the effectiveness of functional jejunal interposition (FJI) and simple jejunal interposition (SJI) as reconstruction methods following total gastrectomy for gastric cancer. The study assessed primary endpoints such as nutritional status and quality of life, as well as secondary endpoints including operative time, intraoperative blood loss, perioperative and postoperative complications, and survival rate.

Methods: A total of 113 patients were randomly assigned to either the FJI group or the SJI group.

Using machine learning to develop a stacking ensemble learning model for the CT radiomics classification of brain metastases.

The objective of this study was to explore the potential of machine-learning techniques in the automatic identification and classification of brain metastases from a radiomic perspective, aiming to improve the accuracy of tumor volume assessment for radiotherapy. By using various machine-learning algorithms, including random forest, support vector machine, gradient boosting machine, XGBoost, decision tree, artificial neural network, k-nearest neighbors, LightGBM, and CatBoost algorithms, a stacking ensemble model was developed to classify gross tumor volume (GTV), brainstem, and normal brain tissue based on radiomic features. Multiple evaluation metrics, including the specificity, sensitivity, negative predictive value, positive predictive value, accuracy, Matthews correlation coefficient, and the Youden index, were used to assess the model's performance.

Uninvolved liver dose prediction in stereotactic body radiation therapy for liver cancer based on the neural network method.

Background: The quality of a radiotherapy plan often depends on the knowledge and expertise of the plan designers.

Aim: To predict the uninvolved liver dose in stereotactic body radiotherapy (SBRT) for liver cancer using a neural network-based method.

Methods: A total of 114 SBRT plans for liver cancer were used to test the neural network method.

The impact of grandparenting on mental health among rural middle-aged and older adults in China: exploring the role of children's support.

Objectives: In the rural regions of China, characterized by a pronounced aging demographic and limited resources, a substantial proportion of middle-aged and older adults engage in grandparenting roles. Yet, the literature lacks consistent evidence regarding the effects of grandparenting on the mental health of this cohort. Accordingly, this study aimed to explore the impact of grandparenting on the mental health of rural middle-aged and older adults, as well as the underlying mechanisms.

Correlation analysis of hypertension, traditional Chinese medicine constitution, and LPL gene polymorphism in the elderly in communities in Shanghai.

Background: Research on the genetic mechanisms of hypertension has been a hot topic in the cardiovascular field.

Objective: To study the correlation between senile hypertension and traditional Chinese medicine (TCM) constitution and lipoprotein lipase (LPL) gene polymorphism and to provide the theoretical basis for TCM prevention and treatment of hypertension.

Methods: The elderly population in communities in Shanghai (hypertensive: 264 cases; non-hypertensive: 159 cases) was taken as the research object.

Macrophage migration inhibitory factor facilitates astrocytic production of the CCL2 chemokine following spinal cord injury.

Spinal cord injury causes accumulation of a large number of leukocytes at the lesion site where they contribute to excessive inflammation. Overproduced chemokines are responsible for the migratory process of the leukocytes, but the regulatory mechanism underlying the production of chemokines from resident cells of the spinal cord has not been fully elucidated. We examined the protein levels of macrophage migration inhibitory factor and chemokine C-C motif chemokine ligand 2 in a spinal cord contusion model at different time points following spinal cord injury.

Characteristics of Heteroresistance in Gastric Biopsies and Its Clinical Relevance.

Background: Antimicrobial susceptibility testing (AST) plays a vital role in anti- treatment, but the traditional AST method has difficulty detecting heteroresistance, which may cause an increased prevalence of resistant strains and eradication failure.

Aims: To investigate the characteristics of heteroresistance in in gastric biopsies and investigate its clinical relevance.

Method: A total of 704 gastric biopsies were selected for 23S rRNA and gyrA gene sequencing, 470 isolates from these biopsies were selected for AST, and the clinical characteristics of the patients were reviewed.

Analysis of m6A-Related lncRNAs for Prognosis Value and Response to Immune Checkpoint Inhibitors Therapy in Hepatocellular Carcinoma.

Introduction: N6-methyladenosine (m6A) modification and long non-coding RNAs (lncRNAs) play pivotal roles in the progression of hepatocellular carcinoma (HCC). However, how their interaction is involved in the prognostic value of HCC and immune checkpoint inhibitors (ICIs) therapy remains unclear.

Methods: The RNA sequencing and clinical data of HCC patients were collected from TCGA database.

[Effects of different intensity exercise on morphology and structure of atrioventricular node and protein expressions of VEGF, VIP and Syn in rats].

To investigate the effects of different intensities of aerobic exercise on the morphology of the atrioventricular node and the expressions of vascular endothelial growth factor (VEGF), vasoactive intestinal peptide (VIP) and synaptophysin (Syn) in rats. Three-month-old SD rats were randomly divided into 3 groups: quiet control group (C), moderate-intensity aerobic exercise group (AE), and high-intensity aerobic exercise group (FE), each with 8 rats. The moderate-intensity aerobic exercise and high-intensity aerobic exercise rat models were rats established by using 8-week treadmill training ways.

Totally Extraperitoneal Herniorrhaphy (TEP): Lessons Learned from Anatomical Observations.

Background: Totally extraperitoneal herniorrhaphy (TEP) is a therapeutic challenge because of its complex anatomical location in inguinal region. The aim of this study was to describe the related surgical anatomy through laparoscopic observation and share the lessons learned from a review of 250 primary inguinal hernia repair procedures performed at our hospital from January 2013 to November 2019. .

Genotype profiles of from gastric biopsies and strains with antimicrobial-induced resistance.

Background And Aims: The genotypic method could significantly shorten the time needed to obtain antibiotic susceptibility data for . The aim of this study was to explore the profile of from gastric biopsies and strains with antibiotic-induced resistance.

Methods: A total of 124 gastric biopsies were used to perform gene sequencing and to perform bacterial culture and susceptibility testing.

Characteristics of antibiotic resistance: data from four different populations.

Aims: To describe the characteristics of () antibiotic resistance in clinical isolates from four populations.

Methods: In total, 1463 strains were examined for antibiotic resistance. Among these strains, 804 were isolated from treatment-naïve adults, 133 from previously treated adults, 100 from treatment-naïve children and 426 from a population who participated in a health survey (age ≥ 40 years).

Fourth-generation quinolones in the treatment of infection: A meta-analysis.

Aim: To assess the efficacy and safety of fourth-generation quinolones for () eradication, we conducted this systematic review and meta-analysis of randomized clinical trials.

Methods: Major literature databases (PubMed, EMBASE and the Cochrane Central Register of Controlled Trials) were searched for relevant articles published prior to February 2018. We performed a meta-analysis of all randomized clinical trials that examined the efficacy of eradication therapies and included fourth-generation quinolones in the experimental arm.

In-vitro characterisation of a novel antimicrobial agent, TNP-2092, against Helicobacter pylori clinical isolates.

Background And Objectives: TNP-2092 is a novel dual-action lead compound consisting of rifamycin SV and 4H-4-oxo-quinolizine pharmacophores, with a broad spectrum of antibacterial activities. This compound is currently in the early stage of clinical development for Helicobacter pylori infection. The aim of the present study was to determine the antibacterial activity of TNP-2092 against H.

A systematic review and meta-analysis of genotypic methods for detecting antibiotic resistance in Helicobacter pylori.

Background: Antibiotic susceptibility testing is essential for tailored treatments to cure Helicobacter pylori (H. pylori) infection. However, phenotypic methods have some limitations.

Dalbergia odorifera extract promotes angiogenesis through upregulation of VEGFRs and PI3K/MAPK signaling pathways.

Ethnopharmacological Relevance: The heart wood of Dalbergia odorifera is a Chinese herbal medicine commonly used for the treatment of various ischemic diseases in Chinese medicine practice.

Aim Of The Study: In this study, therapeutic angiogenesis effects of the Dalbergia odorifera extract (DOE) were investigated on transgenic zebrafish in vivo and human umbilical vein endothelial cells (HUVECs) in vitro.

Materials And Methods: The pro-angiogenic effects of DOE on zebrafish were examined by subintestinal vessels (SIVs) sprouting assay and intersegmental vessels (ISVs) injury assay.

Compatibility Study of Danggui Buxue Tang on Chemical Ingredients, Angiogenesis and Endothelial Function.

Danggui Buxue Tang (DBT) is a classic Chinese herbal formula which consists of Astragali mongholici Radix and Angelica sinensis Radix (ASR). For chemical ingredients, HPLC were performed. Results showed compared with single herbs, DBT decoction could promote the dissolution of ingredients such as ferulic acid and calycosin.

Lentiviral Vector-Mediated p27 Expression Facilitates Recovery After Spinal Cord Injury.

Traumatic spinal cord injury (SCI) causes tissue loss and associated neurological dysfunction attributable to both mechanical damage and secondary biochemical and physiological responses. Upregulation of cell cycle proteins occurs in both neurons and glia after SCI and may contribute to these changes. Increased cell cycle protein is associated with neuronal and oligodendroglial apoptosis, reactive astrogliosis, glial scar formation, and microglial activation.

How Integrated Management Strategies Promote Protein Quality of Cotton Embryos: High Levels of Soil Available N, N Assimilation and Protein Accumulation Rate.

Cottonseed is widely used as a source of ruminant feed and for industrial purposes. Therefore, there is a tremendous need to improve the nutritional value of cotton embryos. In this study, a conventional management (CM) and two integrated cotton management strategies (IMS1, IMS2) were performed at two soil fertility levels to study the relationships among soil N, N assimilation, embryonic protein accumulation and protein quality.

[Hyperspectral parameters and prediction model of soil moisture in coastal saline].

Based on the data of soil moisture content and indoor soil surface spectral reflectance from five sampling sites of coastal saline soil, this paper analyzed the relationship between soil moisture content and soil spectrum in wavelength 350-2500 nm. We determined spectral parameters under ratio spectral index (RSI), normalized difference spectral index (NDSI) and difference spectral index (DI), and established the quantitative model of soil moisture content. The results showed significant negative correlation between spectral reflectance and soil moisture content, and the maximum negative correlation was near 1930 nm (r=0.

The internalization of Helicobacter pylori plays a role in the failure of H. pylori eradication.

Background: Helicobacter pylori (H. pylori) internalization involves invasion of cells by the bacterium. Several studies have shown that H.

Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis.

Ethnopharmacological Relevance: The root of Panax notoginseng is traditionally used as an anti-hemorrhagic agent to promote blood circulation without causing "congealed" blood. Furthermore, the flower of P. notoginseng is a popular, traditional medicine taken daily for the preventing of hypertension and for reducing blood cholesterol profiles.

[Key time window of fiber quality formation in response to short-term higher temperature stress].

By taking two cotton cultivars with different temperature-sensitivity (Sumian 15, temperature-sensitive cultivar and Kemian 1, temperature-insensitive cultivar) as materials, an experiment with two temperature regimes (high temperature: 34 °C [38/30 °C], HT and control: 26 °C [30/22 °C], CK) were set in climate chamber to study the change of key matters in different genotypes cotton in response to high temperature and their relationships with fiber quality. The results showed that as treated in the 34.0 °C high-temperature regime for 5 days at different DPA (days past anthesis), significant change in fiber quality was observed in the temperature-sensitive cultivar Sumian 15.