Increased Incidence of Surgical Intervention for Otitis Media With Effusion Among Patients With Type 2 Inflammatory Diseases.

Background: Otitis media with effusion (OME) is associated with comorbidities such as allergic rhinitis, gastroesophageal reflux disease, asthma, and more. Many of these comorbidities can be caused by type 2 inflammation (T2I). This study aims to determine the risk of undergoing OME surgery in patients with and without T2I disease.

Impact of occupational noise exposure on the hearing level in hospital staffs: a longitudinal study.

The study aimed to evaluate the impact of occupational noise on hearing loss among healthcare workers using audiometry. A longitudinal study was conducted with a six-month follow-up period in a hospital with 21 participants, divided into high-noise-exposure (HNE) and low-noise-exposure (LNE) groups. Mean noise levels were higher in the HNE group (70.

Alveolar Bone Morphologic Predictors for Guided Bone Regeneration Outcome in Anterior Maxilla.

Objectives: This study aimed to explore the influence of alveolar bone morphologic variables on the outcome of guided bone regeneration (GBR) in the anterior maxilla region.

Methods: Twenty-eight patients who received single maxillary anterior tooth delayed implant placed simultaneously with GBR were recruited. Baseline data including age, gender, implant site, implant brand, and bone graft materials were recorded.

Cyclosporine A-induced gingival overgrowth in renal transplant patients accompanied by epithelial-to-mesenchymal transition.

Objective: To investigate the association between the prevalence of cyclosporin A-induced gingival overgrowth and the expression of the epithelial-to-mesenchymal transition factors in the gingival tissues of renal transplant patients.

Background: Gingival overgrowth (GO) is a frequent complication in organ transplant patients treated with the immunosuppressant cyclosporin A (CsA). The epithelial-to-mesenchymal transition (EMT) is considered a factor contributing to CsA-induced GO.

A comprehensive finite-element human ear model to estimate noise-induced hearing loss associated with occupational noise exposure.

Background And Objective: Noise is a common occupational and environmental hazard; however, little is known about the use of computational tools to quantitively analyze data on basilar membrane (BM) damage in noise-induced hearing loss (NIHL). Here, we established a comprehensive three-dimensional finite-element human ear model to quantify the impact of noise exposure on BM and perilymph fluid.

Methods: We used auditory risk units (ARUs) to evaluate the BM damage for subjects (3 men and 5 women; mean age, 32.

Integration of Deep Learning Network and Robot Arm System for Rim Defect Inspection Application.

Automated inspection has proven to be the most effective approach to maintaining quality in industrial-scale manufacturing. This study employed the eye-in-hand architecture in conjunction with deep learning and convolutional neural networks to automate the detection of defects in forged aluminum rims for electric vehicles. RobotStudio software was used to simulate the environment and path trajectory for a camera installed on an ABB robot arm to capture 3D images of the rims.

Comprehensive analysis of circRNA-miRNA-mRNA in oral squamous cell carcinoma.

Objectives: The aim of the present study was to explore expression profiles of circular RNAs (circRNAs) and potential molecular mechanisms in oral squamous cell carcinoma (OSCC).

Design: In this study, high-throughput microarray was used to detect the expression profiles of circRNAs in OSCC. Reverse transcription quantitative PCR (RT-qPCR) was used to quantify the expression of dysregulated circRNAs in microarray.

Effects of age-related tympanic-membrane material properties on sound transmission in the middle ear in a three-dimensional finite-element model.

Background And Objectives: The Young's modulus of the tympanic membrane (TM) is an important modeling parameter in computer simulations of the sound transmission in the ear. Understanding the material mechanics of the TM is essential to improve the coupling between the tympanic membrane and the auditory ossicles. However, the impact of the age-related Young's modulus of the TM on sound transmission is not well known.

[Characteristics of Nutrient Removal in a Pilot-scale A/O with Mixture of Sludge Fermentation Liquor and Tail Water as External Carbon Source].

To resolve the issue of sewage fluctuation and discontinuity in a rural district of China, a new operation mode of replenishing the mixture of fermentation liquor and tail water during the off-flow period was proposed, and the nutrient removal performance of a pilot-scale A/O system with this operation mode was investigated. The results of beaker experiments found that the mixture of tail water and fermentation liquor at a ratio of 12:1 had better denitrification and phosphorus release/absorption characteristics than the raw water, and theoretically had the function of enhancing denitrification and phosphorus removal performances. The results of a 97 d pilot test showed that the removal efficiency of TN and TP was improved after the system was adjusted from the constant flow mode to this new operation mode, and the average removal rate of TN and TP increased from 69.

[Treatment of combined periodontal-pulpal lesions with periodontal therapy].

Purpose: To evaluate the clinical effects of periodontal therapy for combined periodontal-pulpal lesions.

Methods: One hundred and nine patients with periodontal-pulpal lesions were included in this study, with total 120 teeth. All the teeth were treated by perfect root canal therapy, and than divided into group A and B.

[Effect of silencing LASP1 on biological behaviors of oral squamous cell carcinoma cells and IC50 of three anti-tumor drugs].

Purpose: This study was designed to investigate the effects of LASP1 on proliferation, metastasis, invasion, and cycle of oral squamous cell carcinoma cells and analyze the changes of IC50 in three antitumor drugs: cisplatin, apatinib and docetaxel.

Methods: The correlation between LASP1 and survival rate and prognosis of patients with head and neck cancer were analyzed on the human protein atlas data. RT-PCR and Western blot were used to detect mRNA and protein expression of LASP1 in oral squamous cell carcinoma cell lines.

[Clinical study of simultaneous implantation in maxillary molar area after bone graft in patients with residual alveolar bone height<3 mm].

Purpose: To evaluate the clinical effect of maxillary sinus floor elevation and simultaneous implant in patients with residual alveolar bone height <3 mm in the posterior maxillary sinus area.

Methods: From April 1, 2012 to December 31, 2015, 56 patients with lost maxillary posterior teeth and residual alveolar bone height <3 mm were enrolled in this study. During operation, maxillary sinus floor elevation was performed and implants were placed simultaneously.

Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and photoelastic study.

Fabricating Ti alloy based dental implants with defined porous scaffold structure is a promising strategy for improving the osteoinduction of implants. In this study, we use Laser Beam Melting (LBM) 3D printing technique to fabricate porous Ti6Al4V dental implant prototypes with three controlled pore sizes (200, 350 and 500 μm). The mechanical stress distribution in the surrounding bone tissue is characterized by photoelastography and associated finite element simulation.

[The effect of C-SiO composite films on corrosion resistance of dental Co-Cr alloy].

Purpose: To study the effect of carbon-silica composite films on corrosion resistance of Co-Cr alloy in simulated oral environment and provide evidences for clinical application of this new material.

Methods: Co-Cr alloy specimens were cut into appropriate size of 20 mm × 20 mm × 0.5 mm.

Cytoplasmic c-ros oncogene 1 receptor tyrosine kinase expression may be associated with the development of human oral squamous cell carcinoma.

The c-ros oncogene 1 receptor tyrosine kinase () gene encodes a proto-oncogenic protein that has been demonstrated to be involved in the pathogenesis of several types of cancer. The present study aimed to analyze the expression of ROS1 in human oral squamous cell carcinomas (OSCCs), and investigate the association between its expression and the clinicopathological parameters of patients with OSCC. Paraffin-embedded OSCC tissues from 31 patients were obtained and the expression of ROS1 was analyzed by immunohistochemistry.

[Effect of cyclosporine A on TGF-β/Smad3 signaling in rat gingival fibroblasts].

Purpose: The aim of the study was to investigate the effect of cyclosporine A (CsA) on TGF-β/Smad3 signaling in rat gingival fibroblasts and to explore the mechanism of CsA induced gingival overgrowth.

Methods: Healthy Sprague-Dawley rat gingival fibroblasts were cultured with different concentrations of CsA and the cell proliferations were assessed with CCK-8 assay. The mRNA levels of TGF-β1, Smad3 and collagen I were measured by real-time PCR.

[Application of angulated periapical radiography and cone beam computed tomography in detection of missing root canals].

Purpose: To compare the accuracy of angulated periapical radiography and cone beam computed tomography (CBCT) in the detection of missing root canals.

Methods: Before endodontic treatment, 200 teeth were scanned by CBCT and taken conventional periapical radiographs at the routine angle. During the root canal treatment, the radiograph was taken at an angle of 20-30 degree from the mesial or distal of the teeth with files in canal and the diagnosis of missing canals by angulated periapical radiography was compared with the image of CBCT.

Bioinformatics analysis reveals significant genes and pathways to target for oral squamous cell carcinoma.

Purpose: The purpose of our study was to explore the molecular mechanisms in the process of oral squamous cells carcinoma (OSCC) development.

Method: We downloaded the affymetrix microarray data GSE31853 and identified differentially expressed genes (DEGs) between OSCC and normal tissues. Then Gene Ontology (GO) and Protein-Protein interaction (PPI) networks analysis was conducted to investigate the DEGs at the function level.

[Evaluation of three-dimensional changes after sinus floor augmentation with DBBM].

Purpose: The objective of present study was to assess the dimensional stability of the grafting material DBBM (Bio-oss) after maxillary sinus floor augmentation with spiral computed tomography (SCT) scans and 3D reconstruction.

Methods: Two postoperative SCT scans were available from 12 patients who had undergone maxillary sinus lift procedures. CT scan was taken at 2 week after surgical intervention and 6 months later, respectively.

[Application of the fiber-reinforced resin in transitional denture after implantation].

Purpose: To evaluate the clinical effect of transitional restoration by the fiber-reinforced resin bonded bridge in the anterior zone after implantation.

Methods: Twenty-three cases with missing upper/lower central incisor, lateral incisor or canine were collected and randomly divided into the experimental group and the control group. One week after implant operation, the patients in the experimental group were repaired with the fiber-reinforced resin bonded bridge; while 2 weeks after implant operation, the patients in the control group were repaired with the removable partial denture.

[Expression and clinical significance of ErbB3 binding protein ebp1, E-cadherin, ICAM-1 and matrix metalloproteinase-9 in salivary adenoid cystic carcinoma].

Purpose: To investigate the expression of ErbB3 binding protein ebp1, E-cadherin, ICAM-1 and matrix metalloproteinase-9(MMP-9) in salivary adenoid cystic carcinoma(SACC), and to explore their relationship with clinical pathological features.

Methods: Two-step immunohistochemical staining method was used to detect the expression of ebp1 E-cadherin, ICAM-1 and MMP-9 in 33 cases with human SACC and 33 with para-cancerous normal tissues. All data were analyzed with SPSS17.

[Expression of erythroblastic leukemia viral oncogene homolog 3 (ErbB-3) binding protein-1, matrix metalloproteinases, eplthelial cadherin in adenoid cystic carcinoma and correlation analysis].

Objective: To investigate the expression of ErbB-3 binding protein-1 (EBP-1), matrix metalloproteinase 9 (MMP-9) and E-cadherin (E-cad) in adenoid cystic carcinoma and their correlation.

Methods: Immunohistochemistry(PV6000 method) was used to detect EBP-1, MMP-9 and E-cad expression in 66 cases of adenoid cystic carcinoma tissues and matched para-cancerous normal tissues. In this study all cases were successfully followed up.

[The influence of active calcium ions solution on the ultrastructure of the enamel and cementum of extracted teeth and the evaluation of its cytotoxicity].

Purpose: To detect the effect of active calcium ions solution on the ultrastructure of enamel and cementum of the extracted teeth and observe the cytotoxicity of the solution on NIH3T3 cell through cell culture.

Methods: Active calcium ions solution composition was detected with a Quanta200FEG field emission scanning electron microscopy, and the ultrastructure of teeth enamel and cementum was observed before and after the application of calcium ions solution. After diluting the calcium ions solution, MTT assay method was used to observe the impact of active calcium ions solution of different concentrations on the NIH3T3 cells growth.