Publications by authors named "You-Yong Tang"
Article Synopsis
- Exosomes from cancer cells contain tumor-specific molecules, facilitating communication with nearby or distant cells, and are being explored for their potential use in cancer diagnosis, particularly through long non-coding RNAs (lncRNAs).
- The study focused on identifying circulating exosomal lncRNAs—specifically FOXD2-AS1, NRIR, and XLOC_009459—from the serum of patients with colorectal cancer (CRC) compared to healthy individuals using advanced isolation and validation techniques.
- The findings reveal that these lncRNAs are significantly elevated in CRC patients, showing good diagnostic accuracy (AUC values between 0.660 and 0.743) individually, and an improved combined AUC of 0.736 for CRC diagnosis
The high mortality of non-small cell lung cancer (NSCLC) is mainly because the cancer has progressed to a more advanced stage before diagnosis. If NSCLC can be diagnosed at early stages, especially stage 0 or I, the overall survival rate will be largely improved by definitive treatment such as lobectomy. We herein validated two novel circulating serum ExmiRs as diagnostic biomarkers for early-stage NSCLC to fulfill the unmet medical need.
View Article and Find Full Text PDF