Cluster headache (CH) is a severe headache disorder, and this study aims to help differentiate it from secondary headaches caused by structural lesions.
A systematic review of 77 cases revealed that structural issues like vascular problems (37.7%), tumors (32.5%), and inflammation (27.2%) were common underlying causes of CH.
The findings emphasize the need for neuroimaging, especially MRI, in patients showing atypical symptoms to rule out potentially treatable underlying conditions.