Publications by authors named "You-Qin Du"
Purpose: Stereotactic body radiotherapy (SBRT) may have significant immunomodulatory effects that enhance tumor response to immune checkpoint inhibitors. This phase 2 clinical trial was conducted to evaluate the safety and efficacy of combining palliative SBRT with camrelizumab (an anti-PD1 monoclonal antibody) in patients with unresectable hepatocellular carcinoma (uHCC).
Methods: Patients with uHCC, Child-Pugh A/B liver function, and at least one measurable lesion were enrolled between April 2020 and August 2022.
Article Synopsis
- Macroscopic vascular invasion (MVI) is a severe progression of hepatocellular carcinoma (HCC) that is difficult to treat, and this study compares two treatment methods: transarterial chemoembolization (TACE) combined with radiotherapy (RT) versus RT alone.
- In a study involving 148 patients with HCC and MVI, those treated with TACE + RT had significantly better overall survival (OS) and progression-free survival (PFS) compared to those who received RT alone, with improvements noted even after adjusting for patient characteristics.
- The TACE + RT group had comparable rates of complications to the RT group, indicating that combining these treatments may provide better long-term outcomes for patients without increasing adverse effects
Vitamin D Receptor (VDR) belongs to the nuclear receptor (NR) superfamily. Whereas the structure of the ligand binding domain (LBD) of VDR has been determined in great detail, the role of its amino acid residues in stabilizing the structure and ligand triggering conformational change is still under debate. There are 13 α-helices and one β-sheet in the VDR LBD and they form a three-layer sandwich structure stabilized by 10 residues.
View Article and Find Full Text PDFPurpose: The main objective of the present study was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy followed by adjuvant chemotherapy compared with concurrent chemoradiotherapy alone in the treatment of locoregionally advanced nasopharyngeal carcinoma.
Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings.
[Inhibitory effect of total flavonoids of Malus hupehensis on hepatic fibrosis induced by Schistosoma japonicum in mice].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
October 2011
Objective: To investigate the effects of total flavonoids of Malus hupehensis on hepatic fibrosis in mice induced by Schistosoma japonicum.
Methods: The mice model of hepatic fibrosis which infected by cercariae of S. japonicum were randomly divided into 6 groups: Group A as a blank control, Group B as a model, Group C as a positive control by complex liver soften tablet of turtle, Group D, E, F treated with a high dose of 114 mg/(kg x d), middle dose of 57 mg/(kg d), and low dose of 28.